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100 percent oxygen resuscitation after brain injury may do more harm than good to children

The current standard practice of giving infants and children 100 percent oxygen to prevent brain damage caused by oxygen deprivation may actually inflict additional harm, researchers at UT Southwestern Medical Center have found.

1 Jul 2008

Cancer cells revert to normal at specific signal threshold

Cancer starts when key cellular signals run amok, driving uncontrolled cell growth. But scientists at the Stanford University School of Medicine report that lowering levels of one cancer signal under a specific threshold reverses this process in mice, returning tumor cells to their normal, healthy state. The finding could help target cancer chemotherapy to tumors while minimizing side effects for the body's healthy cells.

1 Jul 2008

Protein Ronin shown to be an alternate control for embryonic stem cells

Like the masterless samurai for whom it is named, the protein Ronin chooses an independent path, maintaining embryonic stem cells in their undifferentiated state and playing essential roles in genesis of embryos and their development, said Baylor College of Medicine researchers who reported on this novel cellular regulator in the current issue of the journal Cell.

27 Jun 2008

Study uncovers a mechanism that explains calcium abnormalities in Alzheimer's brain

A new study uncovers a mechanism that directly links mutations that cause early onset Alzheimer's disease (AD) with aberrant calcium signaling. The research, published by Cell Press in the June 26th issue of the journal Neuron, provides exciting molecular insights into the pathology of AD and may lead to new treatment strategies.

25 Jun 2008

Nerve cells derived from stem cells may one day provide improved brain treatments

Scientists at the Burnham Institute for Medical Research have, for the first time, genetically programmed embryonic stem (ES) cells to become nerve cells when transplanted into the brain, according to a study published in The Journal of Neuroscience.

24 Jun 2008

New discovery could lead to new treatments for Alzheimer's

Rutgers researcher Karl Herrup and colleagues at Case Western Reserve University have discovered that a protein that suppresses cell division in brain cells effectively "puts the brakes" on the dementia that comes with Alzheimer's disease (AD). When the brakes fail, dementia results.

24 Jun 2008

Blue curing light for tumors

A blue curing light used to harden dental fillings also may stunt tumor growth, Medical College of Georgia researchers say.

24 Jun 2008

Nerve cells derived from embryonic stem cells and transplanted into mice may lead to improved brain therapies

24 Jun 2008

Automated magnetic resonance imaging technique assists in earlier Alzheimer's diagnosis

An automated system for measuring brain tissue with magnetic resonance imaging (MRI) can help physicians more accurately diagnose Alzheimer's disease at an earlier stage according to a new study published in the July issue of the journal Radiology.

24 Jun 2008

New method for bone tissue engineering wins award

A new and better method for accelerating bone formation in cases of orthopedic injuries and conditions, such as osteoporosis, fractures and disc disorders, has been developed by Nadav Kimelman at the Hebrew University of Jerusalem's Faculty of Dental Medicine.

23 Jun 2008

MIT finds alternative to common colorectal cancer drug oxaliplatin

A compound that accumulates in cells more readily than a commonly used colorectal cancer drug may be just as useful in treating colorectal tumors, but with fewer side effects, MIT researchers have found.

17 Jun 2008

Nanoparticles trigger built-in cell-death signal to overcome drug resistance

One of the most vexing problems in treating cancer is the propensity of tumors to develop resistance to a wide range of anticancer drugs. Over 70 percent of ovarian cancer patients, for example, have drug-resistant tumors at the time of their initial diagnosis, and virtually all patients who relapse have drug-resistant tumors.

15 Jun 2008