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Study links poor sense of smell with increased risk of depression in older adults

In a study that followed more than 2,000 community-dwelling older adults over eight years, researchers at Johns Hopkins Medicine say they have significant new evidence of a link between decreased sense of smell and risk of developing late-life depression.

26 Jun 2023

Is consuming ultra-processed foods associated with an increased risk of venous thromboembolisms?

Scientists examined the association between the consumption of ultra-processed foods and the risk of venous thromboembolisms.

26 Jun 2023

High BMI linked to increased risk of 5 rheumatic diseases

A new study by Uppsala University shows that a higher body mass index (BMI) increases the risk of five different rheumatic diseases: rheumatism, osteoarthritis, gout, psoriatic arthritis and inflammatory spondylitis. The researchers also noted that BMI was a stronger risk factor for women compared to men in terms of gout and psoriatic arthritis. The study will be presented in the journal Arthritis & Rheumatology.

26 Jun 2023

Space travel weakens immune system by altering gene expression in white blood cells

Evidence is mounting that astronauts are more susceptible to infections while in space. For example, astronauts on board the International Space Station (ISS) commonly suffer from skin rashes, as well as respiratory and non-respiratory diseases.

24 Jun 2023

Breakthrough discovery could lead to new treatments for brain metastases

When cancer that starts in the body metastasizes to the brain, it is almost always lethal, in part because so few treatment options exist. Now a new study by Wistar scientists published in Nature Communications shows that a type of brain cell called astrocytes plays an important role in promoting brain metastasis by recruiting a specific subpopulation of immune cells.

24 Jun 2023

UA researcher develops new method to monitor frailty symptoms

A layperson might think of "frail" as simply a synonym for "weak" or "fragile." But in the medical field, frailty is a specific term, meaning – due to factors including inflammation and hormone shifts – a patient has a lack of physiological reserve, or a reduced ability to tolerate stress.

23 Jun 2023

The use of bacterial colonists as therapy carriers is gaining interest for treating cancer

Study describes the use of engineered commensal bacteria to increase antitumor immunity.

23 Jun 2023

Women with higher maternal BMI have shorter breastfeeding duration, finds study

Breastfeeding has significant benefits for both maternal and child health. Research has indicated that women with higher body mass index (BMI) have shorter durations of breastfeeding, but few underlying mechanisms have been identified.

23 Jun 2023

Study finds new way to predict therapy response in metastatic renal cell carcinoma

Dr. Niklas Klümper, resident at the Department of Urology and Pediatric Urology of the University Hospital Bonn (UKB) and working group leader at the Institute for Experimental Oncology (IEO), and Dr. Jonas Saal, resident at the Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology of the UKB, demonstrated a significant improvement in predicting the response to therapy in metastatic renal cell carcinoma by incorporating the level of inflammation, which was assessed using two straightforward blood parameters, alongside the conventional imaging-based approach.

22 Jun 2023

New platform technology bridges the gap between microscopic analysis and multiplex imaging

Researchers at the Ludwig Center at Harvard have developed a platform technology for imaging that enables integration of the methods of microscopic analysis long employed in pathology laboratories with the visualization of multiple molecular markers in individual cells that is now rapidly advancing in research labs.

22 Jun 2023

Brain organoids provide new insights into HSV-1 encephalitis

The herpes simplex virus-1 can sometimes cause a dangerous brain infection. Combining an anti-inflammatory and an antiviral could help in these cases, report scientists with the Rajewsky and Landthaler labs and the Organoid Platform at the Max Delbrück Center in Nature Microbiology.

22 Jun 2023

Study reveals how metformin interacts with the liver and gut to reduce circulating glucose levels

There are still many enigmas about the mechanism of action of metformin, the most prescribed drug to treat diabetes mellitus, also known as type 2 diabetes.

22 Jun 2023

Tranexamic acid use linked to decreased incidence of heterotopic ossification after elbow trauma surgery

For patients undergoing surgery for elbow trauma, treatment with the hemostatic drug tranexamic acid (TXA) is associated with a decreased incidence of heterotopic ossification (HO) – a common complication of abnormal bone formation, reports a study in The Journal of Bone & Joint Surgery.

22 Jun 2023

Circulating cell-free mitochondrial DNA could be useful biomarkers for aging and inflammation

In an eight-year study of more than 600 community-dwelling older adults, Johns Hopkins Medicine researchers say they have further linked levels of cell-free DNA (DNA fragments resulting from cell death) circulating in the blood to chronic inflammation and frailty.

21 Jun 2023

Vagus nerve dysfunction has a central pathogenic role in the pathophysiology of the post-COVID condition

Researchers studied if vagus nerve dysfunction has a central pathogenic role in the pathophysiology of the post-COVID condition.

21 Jun 2023

Vegetarian diet linked to increased risk of varicose veins in men

Varicose veins (VVs) pose a significant medical burden, particularly among women. This study investigates the association between vegetarian and non-vegetarian diets and the risk of VVs in both genders.

20 Jun 2023

Treatment with dupilumab leads to sustained improvements in COPD patients with type 2 inflammation

Chronic obstructive pulmonary disease patients with type 2 inflammation saw rapid and sustained improvements in their disease after treatment with the monoclonal antibody dupilumab, according to a yearlong, Phase 3 clinical trial reported in the New England Journal of Medicine.

20 Jun 2023

Apple-shaped obesity associated with greater inflammation and mortality in COVID-19 patients

Eating an apple a day may keep the doctor away, but having an apple shape is not nearly as healthy. Now, researchers from Japan have shown that people who carry their weight in their bellies may be at greater risk of poor outcomes if they catch COVID-19.

20 Jun 2023

Battle against RSV: Computational design paves way for new polyvalent vaccine

Research focuses on the design of a multi-epitope polyvalent vaccine against Human Respiratory Syncytial Virus (RSV), a leading cause of lower respiratory tract infections. The study utilizes computational methods and immunoinformatics tools to predict potential vaccine candidates and their interactions with Toll-like receptors (TLRs).

19 Jun 2023

Diet alone not the sole culprit: Unraveling the complexities of metabolic disease rise in the U.S.

In a study published in the journal Pharma Nutrition, scientists have explored the long-term impact of Western diet and lifestyle factors on the risk of metabolic disease in the United States.

19 Jun 2023

Inflammation News and Research

Study links poor sense of smell with increased risk of depression in older adults

Is consuming ultra-processed foods associated with an increased risk of venous thromboembolisms?

High BMI linked to increased risk of 5 rheumatic diseases

Space travel weakens immune system by altering gene expression in white blood cells

Breakthrough discovery could lead to new treatments for brain metastases

UA researcher develops new method to monitor frailty symptoms

The use of bacterial colonists as therapy carriers is gaining interest for treating cancer

Women with higher maternal BMI have shorter breastfeeding duration, finds study

Study finds new way to predict therapy response in metastatic renal cell carcinoma

New platform technology bridges the gap between microscopic analysis and multiplex imaging

Brain organoids provide new insights into HSV-1 encephalitis

Study reveals how metformin interacts with the liver and gut to reduce circulating glucose levels

Tranexamic acid use linked to decreased incidence of heterotopic ossification after elbow trauma surgery

Circulating cell-free mitochondrial DNA could be useful biomarkers for aging and inflammation

Vagus nerve dysfunction has a central pathogenic role in the pathophysiology of the post-COVID condition

Vegetarian diet linked to increased risk of varicose veins in men

Treatment with dupilumab leads to sustained improvements in COPD patients with type 2 inflammation

Apple-shaped obesity associated with greater inflammation and mortality in COVID-19 patients

Battle against RSV: Computational design paves way for new polyvalent vaccine

Diet alone not the sole culprit: Unraveling the complexities of metabolic disease rise in the U.S.

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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