Mutation News and Research

RSS

Centrosome amplification may contribute to initiation of cancers, research suggests

Cells begin to accumulate centrosomes - organelles that play a vital role during cell division - before they transform into cancer cells, according to a new study of patients with Barrett's esophagus condition, which is associated with esophageal cancer.

8 May 2018

New microfluidic device captures tumor-specific EVs to guide cancer diagnosis and treatment

Precision cancer treatment relies on obtaining molecular information about the tumor to guide effective treatment decisions.

8 May 2018

Scientists discover how potential new drug targets spinal muscular atrophy

Spinal muscular atrophy (SMA) is a genetic disease that can leave infants with weak muscles and trouble breathing. Many with the disease die before age two. To help these patients, doctors need therapies that target the genetic mutation and stop its progression.

8 May 2018

New drug-based treatment to promote weight loss in young patients with genetic obesity

In a new study researchers from the Institute for Experimental Pediatric Endocrinology of the Charité - Universitätsmedizin Berlin have successfully treat patients whose obesity is caused by a genetic defect.

8 May 2018

Researchers harness the precision of CRISPR to knock out single genes in yeast

Researchers have used CRISPR-Cas9 to develop a technology that can precisely target any gene in the yeast species Saccharomyces cerevisiae.

8 May 2018

FDA grants approval for two drugs administered together to treat aggressive form of thyroid cancer

The U.S. Food and Drug Administration approved Tafinlar (dabrafenib) and Mekinist (trametinib), administered together, for the treatment of anaplastic thyroid cancer (ATC) that cannot be removed by surgery or has spread to other parts of the body (metastatic), and has a type of abnormal gene, BRAF V600E (BRAF V600E mutation-positive).

8 May 2018

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Functional loss of ARID1a, a frequently mutated tumor suppressor gene, causes deficiencies in normal DNA repair and may sensitize tumors to immune checkpoint blockade therapies, according to researchers from The University of Texas MD Anderson Cancer Center.

8 May 2018

Study opens the way for potential new dementia treatments with existing drugs

A new research study by scientists in Australia and the US provides an explanation for why clinical trials of drugs reducing proteins in the brain that were thought to cause dementia and Alzheimer's have failed. The study has opened the way for potential new treatments with existing drugs.

2 May 2018

Potential new treatments for dementia and Alzheimer’s Disease

A study published has uncovered why clinical drug trials reducing proteins associated with the onset of Alzheimer’s Disease and dementia have been unsuccessful.

2 May 2018

Researchers use human and worm data to explore mutational causes of cancer

Researchers at the European Bioinformatics Institute (EMBL-EBI), the University of Dundee and the Wellcome Sanger Institute have used human and worm data to explore the mutational causes of cancer.

2 May 2018

Therapeutic RNA corrects error in genetic processing that leads to familial dysautonomia

Scientists at Cold Spring Harbor Laboratory have identified a therapeutic RNA molecule that corrects the error in genetic processing that leads to familial dysautonomia, a rare inherited neurodegenerative disorder.

30 Apr 2018

Researchers recommend anti-cancer immunotherapies for treatment of thyroid cancer

University of Colorado Cancer Center researchers recently completed the largest-ever study of thyroid cancer genetics, mining the data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers.

27 Apr 2018

Researchers uncover the mystery of B cell receptors

When a pathogen evades or overcomes our innate immune defenses, the adaptive immune system kicks into action. There are two types of adaptive immune responses: cell-mediated immunity mediated by T cells and humoral immunity mediated by antibodies produced by B cells.

27 Apr 2018

Scientists discover potential therapeutic target for devastating premature aging disease

Scientists from the University of Cambridge have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford Progeria Syndrome (HGPS), which is characterized by premature aging.

27 Apr 2018

Research leads to new potential treatment for Hereditary Hemorrhagic Telangiectasia

The work of researchers Francesc Viñals and Mariona Graupera at the Bellvitge Biomedical Research Institute - Catalan Institute of Oncology - University of Barcelona, together with Dr. Antoni Riera-Mestre, has led to a new potential treatment for Hereditary Hemorrhagic Telangiectasia or Rendu-Osler Syndrome, a rare disease that affects blood vessels and had no described treatment.

26 Apr 2018

Advances in genetic testing give new insights to parents of children with epileptic encephalopathy

Advances in genetic testing offer new insights to parents who have a child with a rare but serious form of epilepsy, epileptic encephalopathy (EE), found in one of about every 2,000 births and characterized by developmental disabilities as well as horrible seizures.

26 Apr 2018

‘Rapid autopsy’ programs seek clues to cancer within hours of death

After Keith Beck died of bile duct cancer last year, family members said more than 900 people showed up to pay respects to the popular athletic director at the University of Findlay in northwestern Ohio.

26 Apr 2018

Study shows gene variations associated with malaria risk

Many people of African heritage are protected against malaria by inheriting a particular version of a gene, a large-scale study has shown.

25 Apr 2018

Scientists use CRISPR tool to make multiple edits to DNA samples 'in vitro'

Scientists at Christiana Care Health System's Gene Editing Institute have developed a potentially breakthrough CRISPR gene-editing tool. It could allow researchers to take fragments of DNA extracted from human cells, put them into a test tube, and quickly and precisely engineer multiple changes to the genetic code, according to a new study published today in the CRISPR Journal.

20 Apr 2018

The Swedish Childhood Cancer Foundation awards grant to KI researchers

Ten researchers at Karolinska Institutet have been awarded grants in the Swedish Childhood Cancer Foundation's latest call for funding, during which approximately SEK 62 million was allocated.

19 Apr 2018

Mutation News and Research

Centrosome amplification may contribute to initiation of cancers, research suggests

New microfluidic device captures tumor-specific EVs to guide cancer diagnosis and treatment

Scientists discover how potential new drug targets spinal muscular atrophy

New drug-based treatment to promote weight loss in young patients with genetic obesity

Researchers harness the precision of CRISPR to knock out single genes in yeast

FDA grants approval for two drugs administered together to treat aggressive form of thyroid cancer

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Study opens the way for potential new dementia treatments with existing drugs

Potential new treatments for dementia and Alzheimer’s Disease

Researchers use human and worm data to explore mutational causes of cancer

Therapeutic RNA corrects error in genetic processing that leads to familial dysautonomia

Researchers recommend anti-cancer immunotherapies for treatment of thyroid cancer

Researchers uncover the mystery of B cell receptors

Scientists discover potential therapeutic target for devastating premature aging disease

Research leads to new potential treatment for Hereditary Hemorrhagic Telangiectasia

Advances in genetic testing give new insights to parents of children with epileptic encephalopathy

‘Rapid autopsy’ programs seek clues to cancer within hours of death

Study shows gene variations associated with malaria risk

Scientists use CRISPR tool to make multiple edits to DNA samples 'in vitro'

The Swedish Childhood Cancer Foundation awards grant to KI researchers

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

Latest News