Depressive Disorder News and Research

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Childhood maltreatment has moderating influence on efficacy of psychotherapy

In the current issue of Psychotherapy and Psychosomatics, Klein and colleagues report the effect of childhood maltreatment on the outcome of psychotherapy.

7 Mar 2018

People with MDD feel more negative emotion when remembering painful experiences

People with major depressive disorder (MDD) feel more negative emotion when remembering painful experiences than people without the disorder, according to a new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. The study reports that people with MDD were able to control the negative emotions about as well as people unaffected by MDD, but used somewhat different brain circuits to do so.

6 Mar 2018

Levels of inflammatory biomarkers could predict effectiveness of ECT for people with depression

People with major depression that has not been well controlled by medications and who have a biomarker in their blood indicating a higher level of inflammation may benefit more than people with less inflammation from electroconvulsive therapy to ease symptoms of their depression, according to a new UCLA study.

6 Mar 2018

TSRI scientists discover new target for treating major depressive disorder

Scientists on the Florida campus of The Scripps Research Institute have discovered a new target for treating major depressive disorder, a disease that affects more than 16 million American adults.

1 Mar 2018

Novel method to extract valuable psychiatric symptom information from doctors' notes

Researchers at Massachusetts General Hospital and Harvard Medical School have developed a new method to extract valuable symptom information from doctors' notes, allowing them to capture the complexity of psychiatric disorders that is missed by traditional sources of clinical data.

26 Feb 2018

Depression screening by primary care physicians important for adolescents

According to the American Academy of Paediatrics’ new guidelines released this week, all adolescents should undergo a screening for depression annually. The guidelines is published titled, “Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management,” by the GLAD-PC Steering group.

26 Feb 2018

People with major depressive disorder have reduced arginine levels, study shows

People suffering from major depressive disorder, MDD, have reduced arginine levels, a new study from the University of Eastern Finland shows. Arginine is an amino acid which the body uses to produce, e.g., nitric oxide.

21 Feb 2018

Study reveals the link between genetic variations and major psychiatric disorders

Psychiatric disorders including schizophrenia, autism, and bipolar disorder share common molecular characteristics, despite variations in gene expression.

9 Feb 2018

Depressive symptoms associated with poorer survival in patients with head and neck cancer

In a study of patients with head and neck cancer, even mild depressive symptoms were associated with poorer overall survival.

22 Jan 2018

Study identifies new target for treatment of depression

According to the World Health Organization more than three hundred million people worldwide are affected by major depressive disorder. Unfortunately, the antidepressants commonly used to treat them only work for 50% of the population.

18 Jan 2018

Research provides insights into mechanisms governing healthy longevity

Keio University Global Research Institute, Tokyo publishes the January 2018 issue of KGRI Research Frontiers that includes researcher video profiles of Keio University researchers and research highlights from high impact publications including 'Regenerative medicine needs collaboration in and out of science in order to face current and future challenges; ‘Does eating fish protect you from depression?’; ‘Insights into the molecular mechanisms leading to kidney dysfunction in diabetic patients’; and ‘Ageing to 100 and beyond: Insights from demographic, phenotypic and genetic studies.

12 Jan 2018

Metabolic Syndrome could make it harder for older adults to respond to antidepressant therapy

Researchers suspect that having Metabolic Syndrome makes it harder for older adults to respond to therapies for depression.

11 Jan 2018

C-Path receives FDA’s clinical outcome assessment qualification for SMDDS

Critical Path Institute's Patient-Reported Outcome Consortium announces its first clinical outcome assessment qualification from the US Food and Drug Administration for the Symptoms of Major Depressive Disorder Scale.

18 Dec 2017

Researchers use new approach to identify casual mechanisms in depression

People with major depressive disorder have alterations in the activity and connectivity of brain systems underlying reward and memory, according to a new study by the University of Warwick.

12 Dec 2017

New method helps measure effect of one brain region on another in depression

People with major depressive disorder have alterations in the activity and connectivity of brain systems underlying reward and memory, according to a new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

6 Dec 2017

New study examines effects of gene variant on resting-state brain function in patients with MDD

A new study assessed the effects of a SLC6A15 gene variant on resting-state brain function in patients with major depressive disorder (MDD), comparing the results with those in healthy individuals.

5 Dec 2017

Undocumented Mexican immigrants living in the country at risk for mental disorders

Nearly a quarter of Mexican immigrants who live near the California-Mexico border without legal authorization have a mental disorder, particularly depression or anxiety, according to a new study by Rice University.

30 Oct 2017

New analysis reveals insights into long-term effects of antidepressant drugs

In the current issue of Psychotherapy and Psychosomatics a new analysis discloses insights into the long term effects of antidepressant drugs. Major depressive disorder (MDD) is more often chronic or recurrent in clinical than in community samples.

24 Oct 2017

Antidepressant use in children, adolescents linked to increased risk of type 2 diabetes

A team of researchers from the University of Maryland School of Pharmacy and the University of Maryland School of Medicine found that current (prolonged) use of serotonin reuptake inhibitors – a major class of antidepressant medications – in children and adolescents was associated with a nearly two-fold increased risk of developing type 2 diabetes when compared to youths who formerly used (but eventually discontinued) those medications.