Mouse Model News and Research

RSS

Researchers find gut bacteria rapidly soak up ‘forever chemicals’

Scientists have demonstrated that select human gut bacteria can bioaccumulate and sequester PFAS ‘forever chemicals’, increasing faecal excretion in humanized mice. The findings reveal a potential microbiome-based strategy to reduce PFAS body burden, though clinical benefit in humans remains unproven.

1 Jul 2025

Macrophage-derived lipocalin 2 drives severe pneumonia in SARS-CoV-2 infection

Since the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), understanding the mechanisms underlying severe pneumonia has remained a major research challenge.

1 Jul 2025

Improving RNA drug delivery through intracellular traffic control

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness.

1 Jul 2025

Engineered protein silences harmful T cells in autoimmune disease

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of Type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice.

1 Jul 2025

Brain stimulation restores synaptic plasticity in Alzheimer’s mouse model

Alzheimer's disease (AD) is a debilitating neurodegenerative condition that affects a significant proportion of older people worldwide. Synapses are points of communication between neural cells that are malleable to change based on our experiences.

30 Jun 2025

Oleic acid from olive oil reduces infection-related bone loss with age

A mouse study shows that dietary oleic acid, a key Mediterranean diet component, protects against age-related bone and microbiome damage triggered by periodontal infection. In contrast, a Western-style palmitic acid diet worsens bone loss and destabilizes the gut microbiome.

30 Jun 2025

Shingles and RSV vaccines with AS01 adjuvant reduce dementia risk

Researchers found that older adults who received AS01-adjuvanted shingles or RSV vaccines had a significantly lower risk of developing dementia within 18 months compared to flu vaccine recipients. The protective effect is likely linked to the AS01 adjuvant itself, highlighting new avenues for dementia prevention.

30 Jun 2025

Limiting carcinogen exposure could mitigate liver cancer risk for people with HBV infection

Hepatitis B virus (HBV) infection is known to be associated with the risk of hepatocellular carcinoma (HCC), but how and why they are connected remains unknown.

27 Jun 2025

Study reveals how FOXA1 mutations drive prostate cancer and therapy resistance

A new study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct classes of mutations in the FOXA1 gene-commonly altered in prostate cancer-drive tumor initiation formation and therapeutic resistance.

26 Jun 2025

Study finds overlap between chemotherapy side effects and brain aging

While chemotherapy can be lifesaving, it also damages DNA and leads to cognitive issues known as "chemo brain." These effects resemble the memory and learning problems seen in older adults, prompting University of Oklahoma researchers to investigate this unique overlap of cognitive decline.

26 Jun 2025

New pretreatment method boosts islet transplant survival in diabetes

A pretreatment step could help transplanted pancreatic islets survive longer in patients with type 1 diabetes, according to a new preclinical study from Weill Cornell Medicine investigators. One combination of small molecules extended the cells' lives in female mice, and adding two molecules to the mixture boosted cell survival in male mice.

25 Jun 2025

Targeting ADAM10 may offer hope for retinal disease treatment

New research has found that the endothelial cell-specific A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) regulates abnormal blood vessel growth in the damaged retina, which can cause vision loss or impairment.

25 Jun 2025

New technology unlocks cellular ancestry with DNA barcodes

A landmark study by WEHI scientists has shed new light on one of the most fundamental mysteries of biology: how cells divide and grow into the complex structures that make up our bodies.

24 Jun 2025

New PET radiotracer offers clearer view of brain inflammation

A newly developed PET radiotracer has shown the ability to produce high-quality images of real-time brain inflammation, according to research presented at the Society of Nuclear Medicine and Molecular Imaging 2025 Annual Meeting.

24 Jun 2025

Genetically engineered skin grafts help heal chronic wounds in patients with epidermolysis bullosa

Skin grafts genetically engineered from a patient's own cells can heal persistent wounds in people with an extremely painful dermatologic disease, a Stanford Medicine-led clinical trial has shown.

23 Jun 2025

Inflammation drives early prostate cancer through cellular reprogramming

Prostate cancer is one of the most common cancers and the second leading cause of cancer-related death in men worldwide. However, the mechanisms controlling the early stages of prostate cancer formation are poorly understood.

23 Jun 2025

New intercellular network found to drive liver fibrosis progression

Liver fibrosis, a pathological condition in which the liver becomes stiff and scarred, commonly develops in the progression of chronic liver diseases such as chronic hepatitis and metabolic dysfunction-associated steatohepatitis (MASH).

21 Jun 2025

New 3D model reveals how nose stem cells support sense of smell

Using a newly devised, three-dimensional model to study the regeneration of nerve tissue in the nose, researchers at Tufts University School of Medicine and the Graduate School of Biomedical Sciences (GSBS) and colleagues have discovered that one type of stem cell thought to be dormant may play a more significant role in preserving the sense of smell than originally believed.

19 Jun 2025

New dual-adjuvant vaccine strategy offers hope in the fight against HIV

In the quest to develop an effective HIV vaccine, scientists from Scripps Research have made a significant leap forward. They found that a two-part delivery strategy can train the immune system to produce a stronger response to HIV, offering new hope in the fight against one of the world's most elusive viruses.

19 Jun 2025

Mitochondrial dysfunction drives cerebellar damage in multiple sclerosis

Multiple sclerosis (MS) affects an estimated 2.3 million people worldwide. Approximately 80% of people with MS have inflammation in the cerebellum, the part of the brain that helps control movement and balance, potentially leading to tremors, poor coordination, and trouble with motor control.

16 Jun 2025