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New brain imaging method shows promise for early diagnosis of Parkinson's disease

An international team, led by researchers at the Champalimaud Foundation (CF), has shown – for the first time in a realistic way – that it may be possible to diagnose Parkinson's disease (PD) years before it becomes untreatable, by scanning people's brains with functional magnetic resonance imaging (fMRI).

8 May 2025

Study shows brain estrogen directly regulates appetite in mice

Researchers in Japan found that estrogen produced within the brain, called neuroestrogen, suppresses appetite and reduces body weight in mice by enhancing MC4R expression. The study also showed that neuroestrogen boosts leptin sensitivity, suggesting new targets for obesity treatment.

2 May 2025

Gut immune cells linked to worsening rheumatoid arthritis

After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown in a new study how activity of "good" microbes in the gut is linked to rheumatoid arthritis and, potentially, other autoimmune diseases.

2 May 2025

TDP-43 dysfunction in brain blood vessels may drive Alzheimer's and ALS progression

Reduced levels of a critical protein are linked to devastating brain diseases like Alzheimer's, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Surprisingly, the protein shortage primarily affects the brain's blood vessels.

30 Apr 2025

New protein target offers hope for treating high blood pressure and aortic aneurysms

Oxidative stress can occur when our cells are exposed to harmful molecules called "reactive oxygen species" over time. These reactive oxygen species can damage cells and are found in important disease states, such as high blood pressure and aortic aneurysms.

30 Apr 2025

Brain stimulation at 40Hz boosts memory and neurogenesis in Down syndrome mice

Study provides new evidence that sensory stimulation of gamma-frequency brain rhythm may promote broad-based restorative neurological health response.

25 Apr 2025

Mediterranean diet helps manage rheumatoid arthritis and Hashimoto’s, study shows

The Mediterranean diet shows promise in managing both systemic and organ-specific autoimmune diseases, including rheumatoid arthritis and autoimmune thyroiditis. Its anti-inflammatory and microbiota-modulating properties may reduce disease activity and improve metabolic outcomes.

23 Apr 2025

Tulane researchers identify a potential new way to treat idiopathic pulmonary fibrosis

Researchers at Tulane University have identified a potential new way to treat idiopathic pulmonary fibrosis (IPF), a deadly and currently incurable lung disease that affects more than 3 million people worldwide.

22 Apr 2025

Machine learning unlocks millions of safer CRISPR enzymes for gene editing

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions-but there is always room for improvement.

22 Apr 2025

Researchers find immune system proteins involved in severe cases of schistosomiasis

New insights into the mechanisms that cause more severe cases of schistosomiasis - a disease caused by parasitic worms and second only to malaria in terms of potential harm - have been revealed by researchers at Penn State.

21 Apr 2025

Experimental cancer drug shows promise in boosting tuberculosis treatment

An experimental drug now in clinical trials as a cancer treatment could help boost the power of first-line tuberculosis (TB) treatments by helping infected cells die a gentler death, Johns Hopkins Medicine investigators report, based on mouse-model research of the lung-damaging disease.

21 Apr 2025

Monell study offers renewed hope for people living with Bardet-Biedl Syndrome

A Monell Chemical Senses Center study published this week in the Journal of Clinical Investigation offers renewed hope for individuals living with Bardet-Biedl Syndrome (BBS), a rare genetic disorder characterized by early-onset obesity, compulsive eating, and cognitive impairments.

18 Apr 2025

Mouse Model News and Research

New brain imaging method shows promise for early diagnosis of Parkinson's disease

Study shows brain estrogen directly regulates appetite in mice

Gut immune cells linked to worsening rheumatoid arthritis

TDP-43 dysfunction in brain blood vessels may drive Alzheimer's and ALS progression

New protein target offers hope for treating high blood pressure and aortic aneurysms

Brain stimulation at 40Hz boosts memory and neurogenesis in Down syndrome mice

Mediterranean diet helps manage rheumatoid arthritis and Hashimoto’s, study shows

Tulane researchers identify a potential new way to treat idiopathic pulmonary fibrosis

Machine learning unlocks millions of safer CRISPR enzymes for gene editing

Researchers find immune system proteins involved in severe cases of schistosomiasis

Experimental cancer drug shows promise in boosting tuberculosis treatment

Monell study offers renewed hope for people living with Bardet-Biedl Syndrome

Key enzyme found to influence immune aging and B cell production

New hope for sclerosteosis patients through Wnt pathway inhibition

Mitochondria found to fuel dangerous growth in aging blood stem cells

Multi-omics analysis uncovers molecular drivers of non-viral liver cancer development

Scientists identify critical enzymes for astrocytic GABA production in Alzheimer’s disease

Scientists trace social challenges in autism to specific brain circuit

Study reveals brain circuit behind apathy in advanced cancer

Scientists stop long-COVID symptoms in mice using a new antiviral compound

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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