Spleen News and Research

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Gold nanoparticles shown to safely, effectively ablate low- to intermediate-grade prostate tumors

Biocompatible gold nanoparticles designed to convert near-infrared light to heat have been shown to safely and effectively ablate low- to intermediate-grade tumors within the prostate, according to a study conducted at the Icahn School of Medicine and published in the journal Proceedings of the National Academy of Sciences.

27 Aug 2019

Salk researchers develop new gene-editing tool to target broad range of mutations, cell types

The ability to edit genes in living organisms offers the opportunity to treat a plethora of inherited diseases. However, many types of gene-editing tools are unable to target critical areas of DNA, and creating such a technology has been difficult as living tissue contains diverse types of cells.

26 Aug 2019

FDA approves new drug to treat patients with myelofibrosis

Today, the U.S. Food and Drug Administration approved Inrebic (fedratinib) capsules to treat adult patients with certain types of myelofibrosis.

18 Aug 2019

Antibody may help the immune system fight sepsis-related fungal infections

An antibody that blocks the "programmed cell death" pathway may help the immune system fight off sepsis-related fungal infections, according to animal studies reported in SHOCK: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, Official Journal of the Shock Society.

12 Aug 2019

UCLA researchers discover link between progenitor cells and age-related prostate growth

The prostates of older mice contain more luminal progenitor cells -- cells capable of generating new prostate tissue -- than the prostates of younger mice, UCLA researchers have discovered.

6 Aug 2019

Researchers demonstrate positive and negative role of LRH-1 during inflammation

Immune cells prevent bacteria, parasites or viruses from entering the body when, for example, the intestinal epithelium is injured.

26 Jul 2019

Defective immune signals could underlie some types of fatal heart disease

Researchers have come up with exciting evidence that confirms the role of abnormal immune signaling in myocarditis.

25 Jul 2019

Nanoparticles foster regenerative healing process after spinal cord injury

Paralyzing damage in spinal cord injury is often caused by the zealous immune response to the injury. NIBIB-funded engineers have developed nanoparticles that lure immune cells away from the spinal cord, allowing regeneration that restored spinal cord function in mice.

25 Jul 2019

Disruption of immune cell behavior may spur heart disease, heart failure

On an ice hockey team, the players all start off with identical uniforms, skates and a stick. But if you take one of them, add padding, a glove, and a mask; and switch the stick to one with a larger blade, then you get a goalie.

From Johns Hopkins Medicine 19 Jul 2019

Researchers completely eliminate all traces of HIV from infected mice

For the first time, researchers have successfully removed HIV-1 DNA from the genomes of living animals, a critical step towards a potential cure for the disease.

4 Jul 2019

Scientists discover new way to direct stem cells to heart tissue

In a world first, scientists have found a new way to direct stem cells to heart tissue. The findings, led by researchers at the University of Bristol and published in Chemical Science, could radically improve the treatment for cardiovascular disease, which causes more than a quarter of all deaths in the UK.

4 Jul 2019

Research findings lead to new clinical trial for people with myelofibrosis

Researchers at Huntsman Cancer Institute at the University of Utah (U of U) discovered in laboratory studies that an experimental drug called selinexor may block a crucial survival pathway exploited by myelofibrosis cells.

20 Jun 2019

FAU scientists develop rapid, reliable method to continuously monitor sickle cell disease

Sickle cell disease is a hereditary disorder that affects red blood cells, distorting their natural disc shape into a crescent moon or "sickle" shape. Normal red blood cells move freely through small vessels throughout the body to deliver oxygen.

14 Jun 2019

More screening and new treatments needed for sickle cell disease

The promise of new treatments for sickle cell disease, a group of inherited red blood cell disorders, has never been so great, but it will only be realized if there is constant investment in health policies such as programs for screening newborns, especially in sub-Saharan Africa, where most cases occur.

13 Jun 2019

Study shows how SIRT1 plays key role in maintaining the regenerative potential of leukemic stem cells

Patients with chronic myeloid leukemia can be treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the remission and persist as a major barrier to cure.

11 Jun 2019

First chemoimmunotherapy regimen approved by FDA for patients with diffuse large B-cell lymphoma

Today, the U.S. Food and Drug Administration granted accelerated approval to Polivy (polatuzumab vedotin-piiq), in combination with the chemotherapy bendamustine and a rituximab product (a combination known as "BR"), to treat adult patients with diffuse large B-cell lymphoma (DLBCL) that has progressed or returned after at least two prior therapies.

10 Jun 2019

UAB study reveals how enzyme lipoxygenase drives heart failure after heart attacks

Heart failure after a heart attack is a global epidemic leading to chronic heart failure pathology. About 6 million people in the United States and 23 million worldwide suffer from this end-stage disease that involves dysfunction of the heart, a change that clinicians call cardiac remodeling.

31 May 2019

Spleen News and Research

Gold nanoparticles shown to safely, effectively ablate low- to intermediate-grade prostate tumors

Salk researchers develop new gene-editing tool to target broad range of mutations, cell types

FDA approves new drug to treat patients with myelofibrosis

Antibody may help the immune system fight sepsis-related fungal infections

UCLA researchers discover link between progenitor cells and age-related prostate growth

Researchers demonstrate positive and negative role of LRH-1 during inflammation

Defective immune signals could underlie some types of fatal heart disease

Nanoparticles foster regenerative healing process after spinal cord injury

Disruption of immune cell behavior may spur heart disease, heart failure

Researchers completely eliminate all traces of HIV from infected mice

Scientists discover new way to direct stem cells to heart tissue

Research findings lead to new clinical trial for people with myelofibrosis

FAU scientists develop rapid, reliable method to continuously monitor sickle cell disease

More screening and new treatments needed for sickle cell disease

Study shows how SIRT1 plays key role in maintaining the regenerative potential of leukemic stem cells

First chemoimmunotherapy regimen approved by FDA for patients with diffuse large B-cell lymphoma

UAB study reveals how enzyme lipoxygenase drives heart failure after heart attacks

Scientists use gold nanoparticles to edit genes tied to HIV, inherited blood disorders

Researchers discuss how time of day affects the severity of illness

Circadian rhythm influences immune responses across a range of diseases

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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