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Study aims to provide insights into the dynamics and trajectories of distressed couples

Does relationship quality continue to worsen, stabilize, or improve for distressed, help-seeking couples before they receive assistance? A team of researchers sought to answer that question in a new study examining what happens to couples who seek online help for their relationship, but have to wait six months before beginning an intervention program.

31 Aug 2021

Telemedicine appointments reduce risk of further illness in children with medical complexity

Telemedicine appointments combined with in-person visits significantly reduced the risk of further illness for children with medically complex cases, according to results of a new study by researchers with The University of Texas Health Science Center at Houston.

31 Aug 2021

Community-based program can help reduce in-home falls among older adults

For many aging Americans, the dream of maintaining an active, independent lifestyle while living at home comes crashing down with a fall. Falls are the leading cause of injury, accidental death and premature placement in a nursing home among older adults in the United States.

31 Aug 2021

Investigational vaccine does not provide sufficient protection against HIV infection

An investigational HIV vaccine tested in the "Imbokodo" clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data. The Phase 2b proof-of-concept study, which began in November 2017, enrolled 2,637 women ages 18 to 35 years from five countries.

31 Aug 2021

Telehealth’s limits: Battle over state lines and licensing threatens patients’ options

If you live in one state, does it matter that the doctor treating you online is in another? Surprisingly, the answer is yes, and the ability to conduct certain virtual appointments may be nearing an end.

31 Aug 2021

Durability of cellular immune memory to SARS-CoV-2 after mRNA vaccination

A recent study, available on the bioRxiv* preprint server, investigated the durability of cellular immune memory after mRNA vaccination against SARS-CoV-2 and whether booster jabs affect the durability of different immune response components. The study included testing for antibodies and cellular immune responses in covid patients and recovered individuals.

31 Aug 2021

FDA grants seven years of marketing exclusivity for Octapharma’s Octagam 10%

Octapharma USA today announced the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development (OOPD) has awarded seven years of marketing exclusivity for Octagam® 10% [Immune Globulin Intravenous (Human)], the first and only intravenous immunoglobulin (IVIg) to be indicated for the treatment of adult dermatomyositis (DM).

31 Aug 2021

New strategy combining heart failure with depression treatment improves patients' clinical outcomes

A telephone-delivered nursing care strategy that combined heart failure care management with depression treatment improved patients' clinical outcomes, discovered clinicians from the University of Pittsburgh.

31 Aug 2021

Scientists identify potential biomarkers to predict COVID-19 outcomes

A team of scientists from the United States has recently examined the trajectory of early immune biomarkers in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. They have identified specific plasma proteins that can accurately predict the clinical and virological outcomes in SARS-CoV-2 infected patients. The study is currently available on the medRxiv* preprint server.

31 Aug 2021

University of Kentucky Center for Clinical and Translational Science receives $23.5 million NIH award

The University of Kentucky Center for Clinical and Translational Science has received a $23.5 million, four-year award from the National Center for Advancing Translational Sciences at the National Institutes of Health.

30 Aug 2021

Cardiovascular safety of prostate cancer treatments remains unresolved

The relative cardiovascular safety of different types of androgen deprivation therapy (ADT) for prostate cancer remains unresolved after the PRONOUNCE trial was terminated early. The late breaking research is presented in a Hot Line session today at ESC Congress 2021.

30 Aug 2021

Intensive blood-pressure control benefits older hypertensive patients

Aggressive blood pressure treatment in older hypertensive patients lowers the incidence of cardiovascular events compared to standard therapy, without increasing adverse outcomes. That's the finding of late breaking research presented in a Hot Line session today at ESC Congress 2021.

30 Aug 2021

Screening for atrial fibrillation in the elderly could help avoid stroke and death

Screening for atrial fibrillation in 75- and 76-year-olds could reduce the risk of stroke, severe bleeding and death, according to a study at Karolinska Institutet in Sweden that has been published in the journal The Lancet.

30 Aug 2021

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Self-amplifying RNA (saRNA) is an advanced platform for nucleic acid vaccine development. The backbone is typically derived from an alphaviral genome and encodes a gene of interest (GOI) and a viral replicase that can amplify the genomic and subgenomic RNA.

30 Aug 2021

$Study identifies drug with a positive effect on heart failure patients with preserved ejection fraction$

Study identifies drug with a positive effect on heart failure patients with preserved ejection fraction

Until now, patients with heart failure with preserved ejection fraction – the most common type of heart failure in the elderly – have had no access to evidenced-based treatments. For the first time, a large clinical trial led by Prof. Dr. Stefan Anker from Charité – Universitätsmedizin Berlin has identified a drug which has a distinctly positive effect on prognosis. In patients affected by this type of heart failure, the drug – empagliflozin – reduces the risk of hospitalization or cardiovascular death by 21 percent. The results of this research have been published in the New England Journal of Medicine.

28 Aug 2021

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

The National Institutes of Health has begun a clinical trial to assess the antibody response to an extra dose of an authorized or approved COVID-19 vaccine in people with autoimmune disease who did not respond to an original COVID-19 vaccine regimen.

27 Aug 2021

'Humanized' mouse model beats current approaches for finding the best organ donor

A "humanized" mouse model equipped with the immune system of a patient who needs an organ transplant beats current measures for identifying the best potential living donor, scientists report.

27 Aug 2021

Study examines safety of COVID-19 vaccine in a nationwide mass-vaccination setting

The Clalit Research Institute, in collaboration with researchers from Harvard University, analyzed one of the world's largest integrated health record databases to examine the safety of the Pfizer/BioNTech BNT162B2 vaccine against COVID-19.

27 Aug 2021

Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

A Phase 2 trial led by City of Hope, a world-renowned research and treatment center for cancer and diabetes, suggests that adding the novel ataxia telangiectasia and Rad3-related (ATR) inhibitor drug berzosertib to standard-of-care chemotherapy for patients with metastatic urothelial cancer does not extend progression-free survival.

27 Aug 2021

New blood test could save thousands of lives by predicting sepsis before symptoms appear

Clinicians at Portsmouth's Queen Alexandra Hospital are leading medical trials of a blood test that could help to save thousands of UK lives a year by predicting sepsis days before patients show any symptoms.

26 Aug 2021

Clinical Trial News and Research

Study aims to provide insights into the dynamics and trajectories of distressed couples

Telemedicine appointments reduce risk of further illness in children with medical complexity

Community-based program can help reduce in-home falls among older adults

Investigational vaccine does not provide sufficient protection against HIV infection

Telehealth’s limits: Battle over state lines and licensing threatens patients’ options

Durability of cellular immune memory to SARS-CoV-2 after mRNA vaccination

FDA grants seven years of marketing exclusivity for Octapharma’s Octagam 10%

New strategy combining heart failure with depression treatment improves patients' clinical outcomes

Scientists identify potential biomarkers to predict COVID-19 outcomes

University of Kentucky Center for Clinical and Translational Science receives $23.5 million NIH award

Cardiovascular safety of prostate cancer treatments remains unresolved

Intensive blood-pressure control benefits older hypertensive patients

Screening for atrial fibrillation in the elderly could help avoid stroke and death

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Study identifies drug with a positive effect on heart failure patients with preserved ejection fraction

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

'Humanized' mouse model beats current approaches for finding the best organ donor

Study examines safety of COVID-19 vaccine in a nationwide mass-vaccination setting

Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

New blood test could save thousands of lives by predicting sepsis before symptoms appear

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