immunity News and Research

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Is COVID-19 more severe in pregnancy?

A new study, released as a preprint on the medRxiv* server, indicates that pregnant women are more likely to develop severe disease following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

24 Jun 2021

Could polio vaccines induce cross-reactive antibodies that target SARS-CoV-2?

A new preprint released on the medRxiv* server explores a link between immunity to SARS-CoV-2, the earlier SARS-CoV, and childhood poliovirus vaccination. Almost 90% of the world’s people have received this vaccine, but antibodies elicited by it reduce over time and are almost absent at the end of adolescence.

24 Jun 2021

SARS-CoV-2 causes ER-stress-activated unfolded protein response leading to cell death

A new study describes the varying ways in which the virus co-opts the machinery of the host cell following infection to evade or modulate the host immune response, alter the pattern of translation of viral proteins, and the release of new viral particles.

24 Jun 2021

New tablet-sized device can profile multiple COVID-19 antibodies and biomarkers simultaneously

Biomedical engineers at Duke University in the USA have developed a device that detects coronavirus disease (COVID-19) antibodies as well as biomarkers that distinguish between antibodies produced in response to SARS-CoV-2 and four other coronaviruses with complete accuracy.

24 Jun 2021

Bivalent DNA SARS-CoV-2 vaccine induces strong humoral and cellular immunity in mice

A team of UK-based scientists has developed and validated a DNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that encodes both spike receptor-binding domain (RBD) and nucleocapsid of the virus as vaccine immunogens.

24 Jun 2021

Special type of stem cell can reduce the amount of HIV virus

In a groundbreaking study, a team of UC Davis researchers has discovered a special type of stem cell that can reduce the amount of the virus causing AIDS, boosting the body's antiviral immunity and repairing and restoring the gut's lymphoid follicles damaged by the simian immunodeficiency virus (SIV), the equivalent of the human immunodeficiency virus (HIV) in non-human primates.

24 Jun 2021

Internal communication network in mammals provides new insights on obesity, skin disorders

National Institutes of Health scientists and their collaborators have identified an internal communication network in mammals that may regulate tissue repair and inflammation, providing new insights on how diseases such as obesity and inflammatory skin disorders develop. The new research is published in Cell.

24 Jun 2021

A study of circulating biomarkers in hospitalized patients infected with SARS-CoV-2 alpha variant

Now, a new study published on the medRxiv* preprint server proposes a rapid method to identify the mutations in B.1.1.7 (N501Y mutation and H69/V70 deletion) and the impact of this variant on various biomarkers in hospitalized patients. This is the first study that correlates the biomarker levels to SARS-CoV-2 variants.

23 Jun 2021

SARS-CoV-2 detection with a simple, inexpensive, and sensitive molecular test

Researchers from the US recently described a rapid molecular test named WHotLAMP for the detection of SARS-CoV-2 in saliva. WHotLAMP is easy to use, very sensitive at 3.6 viral RNA copies per microliter of saliva, specific, and inexpensive. This study is published on the medRxiv*preprint serve.

23 Jun 2021

CD39+ monocyte count higher in pregnant than non-pregnant COVID-19 patients

A new study published on the bioRxiv* server describes the changes in the representation of a subset of activated monocytes in this group of patients.

23 Jun 2021

Repeated vaccination could control infection with SARS-CoV-2 variants among infection-naïve individuals

Researchers have suggested that repeated vaccination against SARS-CoV-2 may enable previously uninfected individuals to cope with viral variants.

23 Jun 2021

Indian SARS-CoV-2 variant has unique infection and immune escape strategy say researchers

Researchers have conducted a study suggesting that the B.1.617 lineage of SARS-CoV-2 that emerged in India has evolved a unique strategy.

23 Jun 2021

Vaccinated individuals previously infected with SARS-CoV-2 show robust neutralization of the B.1.1.7 variant

New research published in the journal Viruses suggests recovering from a coronavirus disease 2019 (COVID-19) infection provides immunity against the B.1.1.7 (or UK) variant. The time when the previous infection took place and the variant involved in prior infection influenced cross-neutralization.

23 Jun 2021

Study shows equitable allocation strategies for SARS-CoV-2 vaccines have a comparative edge

In a recent paper, US researchers demonstrate that equitable distributions of vaccines against COVID-19 are a very optimal approach.

23 Jun 2021

Longitudinal study finds SARS-CoV-2 neutralizing antibodies decline a year after infection

Research led by Xin Zheng of Huazhong University of Science and Technology in Wuhan, China, found that about 90% of patients who recovered from COVID-19 continued to have IgG antibodies targeting the N-domain and receptor-binding domain of the spike protein. However, approximately 43% of patients showed signs of neutralizing antibody activity.

23 Jun 2021

Vaccine side effects should be viewed as a sign of efficacy, say immunologists

The rapid development of safe and efficacious vaccines against SARS-CoV-2 has offered hope that the global COVID-19 pandemic may soon be under control. However, vaccinations remain incomplete in many developed nations, and lag further still in the developing world.

23 Jun 2021

First spatial scan analysis helps identify hotspots of undervaccinated children

The map of Montana Kayla Irish pulls up is peppered with red circles, each cluster providing details behind one of today's timely topics - childhood vaccination.

23 Jun 2021

GenScript and Duke-NUS announce notice of allowance for “Surrogate Virus Neutralization Technology”

GenScript Biotech Corporation ("GenScript", Stock Code: 1548.HK), a world-leading life sciences research and application service and product provider, and Duke-NUS Medical School, a premier, research intensive medical school, announced today that the U.S. Patent and Trade Office has issued a notice of allowance for the patent application for a novel Surrogate Virus Neutralization Technology (sVNT).

23 Jun 2021

Is Rand Paul mixing up the vaccine message for Covid survivors?

Last week, Sen. Rand Paul (R-Ky.) posted a Twitter thread asserting that people who have survived a Covid-19 infection were unlikely to be reinfected and have better immunity against variants than those who have been vaccinated against — but not infected by — SARS-CoV-2, the virus that causes Covid.

22 Jun 2021

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

An interesting new study describes the activities of a family of viral enzymes called two-histidine-phosphoesterases (2H-PEs), found in coronaviruses (CoVs) and rotaviruses, as well as a mammalian A-kinase anchoring protein enzyme, AKAP7, that shares the same function. Together called 2’,5’-PEs, these enzymes all break down 2’,5’-oligoadenylate compounds that activate the antiviral enzyme ribonuclease L (RNase L).

21 Jun 2021

immunity News and Research

Is COVID-19 more severe in pregnancy?

Could polio vaccines induce cross-reactive antibodies that target SARS-CoV-2?

SARS-CoV-2 causes ER-stress-activated unfolded protein response leading to cell death

New tablet-sized device can profile multiple COVID-19 antibodies and biomarkers simultaneously

Bivalent DNA SARS-CoV-2 vaccine induces strong humoral and cellular immunity in mice

Special type of stem cell can reduce the amount of HIV virus

Internal communication network in mammals provides new insights on obesity, skin disorders

A study of circulating biomarkers in hospitalized patients infected with SARS-CoV-2 alpha variant

SARS-CoV-2 detection with a simple, inexpensive, and sensitive molecular test

CD39+ monocyte count higher in pregnant than non-pregnant COVID-19 patients

Repeated vaccination could control infection with SARS-CoV-2 variants among infection-naïve individuals

Indian SARS-CoV-2 variant has unique infection and immune escape strategy say researchers

Vaccinated individuals previously infected with SARS-CoV-2 show robust neutralization of the B.1.1.7 variant

Study shows equitable allocation strategies for SARS-CoV-2 vaccines have a comparative edge

Longitudinal study finds SARS-CoV-2 neutralizing antibodies decline a year after infection

Vaccine side effects should be viewed as a sign of efficacy, say immunologists

First spatial scan analysis helps identify hotspots of undervaccinated children

GenScript and Duke-NUS announce notice of allowance for “Surrogate Virus Neutralization Technology”

Is Rand Paul mixing up the vaccine message for Covid survivors?

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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