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Study reveals functional dynamics of ion channels

Most ion channels are very selective about the ions, which may or may not pass through them. They may be conductive for potassium ions and non-conductive for sodium ions or vice versa.

19 Feb 2018

Lab-grown cerebellar cells may help explain how ASD develops at molecular level

Increasing evidence has linked autism spectrum disorder with dysfunction of the brain's cerebellum, but the details have been unclear. In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex, a genetic syndrome that often includes ASD-like features.

19 Feb 2018

Study sheds light on biology that guides behavior across different stages of life

Put 50 newborn worms in 50 separate containers, and they'll all start looking for food at roughly the same time. Like members of other species, microscopic C. elegans roundworms tend to act like other individuals their own age.

19 Feb 2018

Fathers maybe passing on ovarian cancer genes to their daughters

According to a team of researchers from the Roswell Park Cancer Institute, a new gene mutation could be responsible for ovarian cancers and this could be passed on from fathers to their daughters.

16 Feb 2018

Scientists discover adult endothelial stem cells capable of generating fully functional blood vessels

The proper function of blood vessels is essential to life: blood vessels are responsible for transporting oxygen-rich red blood cells, nutrients, and immune cells throughout the body, to name just a few functions. Defects in blood vessels can correspondingly lead to a variety of life-threatening diseases.

15 Feb 2018

Study reveals new link between bone cells and blood glucose level

The skeleton is often seen as an inert tissue, but this perception is quite wrong. In fact, the skeleton is constantly being remodeled: old bone fragments are broken down and new bone matrix is deposited, overall leading to a completely renewed skeleton every ten years.

14 Feb 2018

Scientists suggest new strategy to inhibit untreatable, deadly nerve sheath tumors

Genomic profiling of mostly untreatable and deadly nerve sheath tumors led scientists to test a possible therapeutic strategy that inhibited tumor growth in lab tests on human tumor cells and mouse models, according to research in the journal Cancer Cell.

13 Feb 2018

Researchers use molecular simulations to understand lung cancer drug resistance

Scientists from the Universities of Bristol and Parma, Italy, have used molecular simulations to understand resistance to osimertinib - an anticancer drug used to treat types of lung cancer.

12 Feb 2018

Could a rare, deadly ‘superbug’ fungus be gaining a foothold?

The number of U.S. patients infected with a rare but dangerous fungal "superbug" called Candida auris has climbed quickly to 200 as of Dec. 31, according to the latest figures from the federal Centers for Disease Control and Prevention.

12 Feb 2018

Study of men with inherited DNA repair mutations opens new therapeutic avenues in prostate cancer

Selected by the American Society of Clinical Oncology to first outing during its Genitourinary Cancers Symposium, Translating Evidence to Multidisciplinary Care, February 8 - 10 (San Francisco, USA), Joaquin Mateo, Principal Investigator of VHIO's recently created Prostate Cancer Translational Research Group, will today reveal findings from a retrospective and international study showing for the first time that patients with inherited DNA repair mutations benefit from standard therapies in a similar way to other metastatic prostate cancer patients.

9 Feb 2018

Alzheimer’s study on mice reveals important mechanism behind neural hyperactivity

Alzheimer´s disease is the key cause of dementia in elderly patients. Those affected develop deficiencies in their abilities to learn, think logically, communicate, and to master the challenges of everyday life.

9 Feb 2018

International research collaboration finds genetic mutation linked to Crohn's disease

A genetic mutation was found to be associated with Crohn's disease. The discovery was made by international research collaboration and was published in the prestigious journal Science Translational Medicine.

8 Feb 2018

Myriad’s myRisk Hereditary Cancer test finds inherited gene mutations in more than 12% of prostate cancer patients

Myriad Genetics, Inc., a leader in molecular diagnostics and personalized medicine, announced today that results from a large 1,162 patient study of the Myriad myRisk Hereditary Cancer test will be featured during the poster presentation at the 2018 Genitourinary Cancer Symposium in San Francisco, Calif.

8 Feb 2018

Researchers identify presence of ER gene fusion proteins in treatment-resistant breast cancer

At Magee-Womens Research Institute and UPMC Hillman Cancer Center, a large team of clinical and laboratory researchers dedicated to understanding treatment resistance in the most common form of breast cancer have identified a new genetic change in the estrogen receptor that contributes to therapy resistance.

7 Feb 2018

USC scientists uncover cellular mechanism responsible for ALS and frontotemporal dementia

Scientists have for the first time discovered a mechanism that limits the number of "cellular janitors" in the nervous system, leading to increased risk for two neurodegenerative diseases: amyotrophic lateral sclerosis and frontotemporal dementia, according to a Keck School of Medicine of USC study published today in Nature Medicine.

7 Feb 2018

New CRISPR gene-editing technique can correct majority of mutations that cause DMD

Scientists have developed a CRISPR gene-editing technique that can potentially correct a majority of the 3,000 mutations that cause Duchenne muscular dystrophy (DMD) by making a single cut at strategic points along the patient's DNA, according to a study from UT Southwestern Medical Center.

6 Feb 2018

Researchers identify potential 'first-line' treatment for rare bone loss disease

A possible 'first-line' treatment for a rare bone loss disease has been identified by a research team led by Tohoku University in Japan. The research findings, published in the journal Molecular Cell, could also provide insight into treating age-related osteoporosis.

6 Feb 2018

Scientists discover rare hypertension disease gene

More than a billion people worldwide suffer from high blood pressure (hypertension). Prolonged hypertension damages blood vessels, which can result in damage to the heart, the kidneys, and the brain. Possible consequences include heart attack, kidney failure, and stroke.

5 Feb 2018

Loved one's experience has impact on woman's cancer prevention decisions

A woman's memories of a loved one's experience with cancer could play a significant role in how she approaches breast cancer prevention in her own life, a new study has found.

5 Feb 2018

Novel method can edit genes with substantially fewer errors

Gene therapy is an emerging strategy to treat diseases caused by genetic abnormalities. One form of gene therapy involves the direct repair of a defective gene, using genome-editing technology such as CRISPR-Cas9. Despite its therapeutic potential, genome editing can also introduce unwanted and potentially harmful genetic errors that limit its clinical feasibility.

5 Feb 2018

Mutation News and Research

Study reveals functional dynamics of ion channels

Lab-grown cerebellar cells may help explain how ASD develops at molecular level

Study sheds light on biology that guides behavior across different stages of life

Fathers maybe passing on ovarian cancer genes to their daughters

Scientists discover adult endothelial stem cells capable of generating fully functional blood vessels

Study reveals new link between bone cells and blood glucose level

Scientists suggest new strategy to inhibit untreatable, deadly nerve sheath tumors

Researchers use molecular simulations to understand lung cancer drug resistance

Could a rare, deadly ‘superbug’ fungus be gaining a foothold?

Study of men with inherited DNA repair mutations opens new therapeutic avenues in prostate cancer

Alzheimer’s study on mice reveals important mechanism behind neural hyperactivity

International research collaboration finds genetic mutation linked to Crohn's disease

Myriad’s myRisk Hereditary Cancer test finds inherited gene mutations in more than 12% of prostate cancer patients

Researchers identify presence of ER gene fusion proteins in treatment-resistant breast cancer

USC scientists uncover cellular mechanism responsible for ALS and frontotemporal dementia

New CRISPR gene-editing technique can correct majority of mutations that cause DMD

Researchers identify potential 'first-line' treatment for rare bone loss disease

Scientists discover rare hypertension disease gene

Loved one's experience has impact on woman's cancer prevention decisions

Novel method can edit genes with substantially fewer errors

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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