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Researchers identify intermediate pathway that modifies synthesis and structure of cell wall

An accumulation of an unexpected intermediate of the peptidoglycan recycling pathway that is able to modulate the synthesis and structure of the cell wall, has been found by researchers at Umeå University, Sweden.

19 May 2020

Novel insights on SARS-CoV-2 cell entry may inform further vaccine and treatment development

A research group from Harvard Medical School reported two cryo-electron microscopy structures derived from a single preparation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in their paper available on the preprint server bioRxiv. Understanding the nuances of prefusion and postfusion conformations shed light on viral cell entry and may, in turn, guide the development of vaccines and drugs.

18 May 2020

Cancer biologists identify important drivers of tumor resistance

Cancer biologists at the Mays Cancer Center, home to UT Health San Antonio MD Anderson, have identified important drivers that enable tumors to change their behavior and evade anticancer therapies.

18 May 2020

Study aims to identify markers that predict how COVID-19 affects patients

COVID-19 is the UK's largest public health crisis since World War II. There is an urgent need to identify why some patients with the virus do very well whereas others need to be admitted to intensive care and may die from the disease.

18 May 2020

Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

MIT neuroscientists have discovered that an enzyme called HDAC1 is critical for repairing age-related DNA damage to genes involved in memory and other cognitive functions.

18 May 2020

Study shows human monoclonal antibodies can effectively neutralize SARS-CoV-2

US researchers have published a proof of concept on the efficacy of human monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in laboratory conditions, as well as their pioneering use in a mouse model. The study is available on the preprint server bioRxiv*.

17 May 2020

Child abuse survivors more likely to develop cardio-metabolic disease in adulthood

People who have experienced maltreatment during childhood are significantly more likely to develop conditions such as heart disease, high blood pressure and type two diabetes in adulthood, a new UK study has found.

15 May 2020

Remote consulting practices should be adopted during COVID-19 pandemic, say researchers

Remote consulting practices should be adopted widely during the COVID-19 pandemic to help low and middle income countries to help combat the virus and to provide quality healthcare to patients in the long-term, argue a team of researchers at the University of Warwick.

15 May 2020

Chest X-rays can help predict covid-19 severity in young and middle-aged adults

Chest X-rays performed on young and middle-aged adults with COVID-19 when they arrive at the emergency room can help doctors predict who is at higher risk of severe illness and intubation, Mount Sinai researchers report

15 May 2020

Mouse model helps track organism’s development from embryonic stage to adulthood

Scientists at the Stem Cell Research program at Boston Children's Hospital and Dana-Farber Cancer Institute/Harvard Medical School have devised a mouse model that lets researchers track every cell in the body, from the embryonic stage until adulthood.

15 May 2020

New treatment discovered to reduce swelling after brain and spinal cord injuries

Scientists have discovered a new treatment to dramatically reduce swelling after brain and spinal cord injuries, offering hope to 75 million victims worldwide each year.

15 May 2020

Researchers study how brain cancer cells acquire resistance to radiation

In a vertical climb to avoid collision with a towering mountain, a plane ejects cargo to gain altitude. Investigators at the University of Minnesota showed that cancer cells perform similar feats in escaping the killing effects of radiation.

14 May 2020

Anti-inflammatory drug may improve respiratory function in some severe COVID-19 cases

A small study in Greece found that the clinically approved anti-inflammatory drug anakinra, used to treat rheumatoid arthritis, improved respiratory function in patients with severe coronavirus disease 2019 (COVID-19).

14 May 2020

Processes underlying the damaging effects of brain injury can preserve memory function

A study examining the effect of the immune receptor known as Toll-like Receptor 4, or TLR4, on how memory functions in both the normal and injured brain has found vastly different cellular pathways contribute to the receptor's effects on excitability in the uninjured and injured brain.

13 May 2020

New study to evaluate drug combination treatment for uveitis

Two in 10,000 people are at risk of serious sight loss from a form of eye inflammation known as uveitis. A new clinical research study, led by the University of Bristol and University Hospitals Bristol and Weston NHS Foundation Trust (UHBW), will evaluate a drug combination treatment for the eye disease thanks to funding of £2.5 million by the National Institute for Health Research (NIHR).

13 May 2020

Analysis of single-cell data indicates that SARS-Cov-2 targets many cell types

Before it can sicken people, the new coronavirus must first sneak into their cells. But not any cell will do. The virus can enter only those with a certain combination of molecules on their surfaces.

13 May 2020

New method to control inflammatory response induced by COVID-19

Severe COVID-19 illness can result in excessive inflammation throughout the body, including the lungs, heart and brain. University of Minnesota Twin Cities student Molly Gilligan recently published an article in the journal Cancer & Metastasis Reviews that studied the human body's robust inflammatory response to the SARS-CoV-2 virus, which is now recognized as a hallmark symptom.

13 May 2020

Finding new therapeutic strategies for aggressive T-cell acute lymphoblastic leukemia

Aiming to identify new therapeutic strategies for the aggressive hematological disease T-cell acute lymphoblastic leukemia (T-ALL), Rutgers Cancer Institute of New Jersey resident researcher Daniel Herranz Benito, PhD, along with collaborators from Princeton University, found a new drug that has therapeutic effect against T-ALL by inhibiting SHMT and is complementary to standard-of-care treatment.

12 May 2020

COVID-19 may contribute to exponential growth of Parkinson's disease in future

Parkinson's disease (PD) is expected to reach over 14 million cases worldwide by 2040. As longevity increases, so does the number of persons living with PD.

12 May 2020

Clinical trial to test the efficacy of defibrotide medicine for reducing COVID-19 death rate

The Neurosciences Institute, mixed centre of the Spanish National Research Council and the Miguel Hernández University of Elche, have collaborated on the first clinical trial conducted in the world to test whether the defibrotide medicine, which has already been authorized to treat a severe obstruction of the hepatic sinusoidal veins of people who have undergone a bone marrow transplant, can be used as therapy against COVID-19.

12 May 2020

Medical School News and Research

Researchers identify intermediate pathway that modifies synthesis and structure of cell wall

Novel insights on SARS-CoV-2 cell entry may inform further vaccine and treatment development

Cancer biologists identify important drivers of tumor resistance

Study aims to identify markers that predict how COVID-19 affects patients

Neuroscientists discover anti-aging molecule that repairs age-related DNA damage

Study shows human monoclonal antibodies can effectively neutralize SARS-CoV-2

Child abuse survivors more likely to develop cardio-metabolic disease in adulthood

Remote consulting practices should be adopted during COVID-19 pandemic, say researchers

Chest X-rays can help predict covid-19 severity in young and middle-aged adults

Mouse model helps track organism’s development from embryonic stage to adulthood

New treatment discovered to reduce swelling after brain and spinal cord injuries

Researchers study how brain cancer cells acquire resistance to radiation

Anti-inflammatory drug may improve respiratory function in some severe COVID-19 cases

Processes underlying the damaging effects of brain injury can preserve memory function

New study to evaluate drug combination treatment for uveitis

Analysis of single-cell data indicates that SARS-Cov-2 targets many cell types

New method to control inflammatory response induced by COVID-19

Finding new therapeutic strategies for aggressive T-cell acute lymphoblastic leukemia

COVID-19 may contribute to exponential growth of Parkinson's disease in future

Clinical trial to test the efficacy of defibrotide medicine for reducing COVID-19 death rate

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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