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French scientists suggest nicotinic agonists could treat COVID-19

Contrary to the warnings issued by health agencies worldwide against cigarette smoking amid the coronavirus disease (COVID-19), a new paper suggests the possibility that nicotine, a component of tobacco, could prevent coronavirus infection.

28 Apr 2020

Schizophrenia related to abnormal fatty metabolism in the brain

Researchers discovered a brain deficiency in people with schizophrenia that could lead to development of new drug therapies.

28 Apr 2020

CNIC researchers develop mouse model to examine the mechanical function of proteins

The Molecular Mechanics of the Cardiovascular System group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), led by Jorge Alegre Cebollada, in partnership with an international scientific team, has generated the first experimental mouse model that allows direct analysis of the mechanical function of proteins in living organisms.

28 Apr 2020

Researchers discover a new mode of protein degradation by ubiquitin-proteasome system

The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins.

28 Apr 2020

Research on SARS-CoV-2 spike protein may lead to new vaccines and treatments

The virus that causes COVID-19 is studded on its exterior with "spike proteins," a key component in its ability to infect human cells. Two University of Georgia researchers, Rob Woods and Parastoo Azadi, are investigating the proteins and sugars on the surface of the virus with the goal of finding information that could lead to vaccines and therapeutics.

28 Apr 2020

Gut microbiota could predict severity of COVID-19

The COVID-19 pandemic is spreading to every corner of the world. But not everyone is falling sick at the same rate. A new study published on the preprint server medRxiv in April 2020 suggests that the composition of the gut microbiome could partially explain the difference in susceptibility. This adds a new dimension to what is currently known about the disease.

27 Apr 2020

Scientists elucidate novel disease processes involved in pulmonary fibrosis development

Working alongside research groups from Heidelberg, researchers from Charité - Universitätsmedizin Berlin have elucidated the novel disease processes involved in the development of pulmonary fibrosis.

27 Apr 2020

Researchers harness the power of AI to accelerate drug discovery

As the COVID-19 crisis continues to develop, researchers around the world are attempting to find the most effective treatment to combat the poorly understood virus behind this disease.

27 Apr 2020

Four drugs that could halt preterm labor identified

As the number of preterm births in the U.S. continues to rise, there is an increasing need for new approaches to prevent preterm labor from progressing to preterm birth. Researchers have discovered a common molecular pathway in women who experience preterm labor and are using this insight to develop new treatments for woman who experience early labor.

27 Apr 2020

Patients with aggressive form of skin cancer can benefit from new type of immunotherapy

In what is believed to be a first-of-its-kind study to evaluate the safety of a type of immunotherapy before surgery in patients with an aggressive form of skin cancer, researchers report that the treatment eliminated pathologic evidence of cancer in nearly half of the study participants undergoing surgery.

27 Apr 2020

Investigational drug may hold benefit for patients with lung and ovarian cancers

In a first-time disclosure of IPN60090, a small-molecule inhibitor of the metabolic enzyme glutaminase (GLS1), researchers from The University of Texas MD Anderson Cancer Center's Therapeutics Discovery division and Ipsen Biopharmaceuticals reported the preclinical discovery and early-stage clinical development of this novel drug. IPN60090, now under investigation in a Phase I trial, may hold benefit for certain patients with lung and ovarian cancers.

27 Apr 2020

Researchers re-purpose cancer-fighting artificial antibodies for COVID-19

Researcher Paula Bates, John Trent, and Don Miller developed a therapeutic drug that could potentially block the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the COVID-19 pandemic. Their research was initially aimed at helping patients suffering from multiple types of cancer.

27 Apr 2020

Rice University looks to ‘trap and zap’ SARS-CoV-2 in wastewater

A team of researchers from Rice University has won a National Science Foundation (NSF) RAPID grant to adapt their wastewater nanotechnology project to help trap and inactivate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), (which causes COVID-19 disease), in wastewater. This could help public health officials deal with the threat of disease transmission through wastewater.

27 Apr 2020

Recombinant protein produces neutralizing COVID-19 antibodies in primate model

A new study reports the induction of high levels of neutralizing antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing the current pandemic of COVID-19. This promising finding was reported on the preprint server bioRxiv on April 2020.

26 Apr 2020

New brain cell models created to evaluate therapies for Sanfilippo C syndrome

The Sanfilippo syndrome type C is a severe neurodegenerative disease which appearws during the first years of life and for which there is no treatment yet.

24 Apr 2020

Therapeutic antibody successfully prevents metastases in mice with breast or lung cancer

A receptor in the cell layer that lines the blood vessels from the inside stimulates both the formation of new blood vessels in tumors and metastasis.

24 Apr 2020

Scientists are developing synthetic COVID-19 antibody to treat sick patients

A team of researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with GenScript, is developing a synthetic antibody to SARS-CoV-2, the virus that causes coronavirus disease (COVID-19). This antibody is intended to block the virus from entering human lung cells, and would be another potential treatment option for COVID-19.

24 Apr 2020

Study: JNK and BNP activity can reverse cardiovascular damage, reduce risk of death from sepsis

Overreaction is rarely useful, and in the case of the human immune system, it can be outright deadly. When the body overreacts to an infection, the result is sepsis - a life-threatening condition that frequently leads to acute organ dysfunction, including deterioration of the heart and blood vessels, which make up the cardiovascular system.

24 Apr 2020

Graphene-based nanomedicine enables targeted cancer treatment at molecular level

"Three" kinds of regalia such as crown, orb, and sward are often necessary to be a high king for conquering the world. For fighting off cancerous diseases, what do we need? This "triple" chemical modified nanomaterial might be save the patient.

23 Apr 2020

Low-cost, portable detector takes about 30 minutes to identify pathogens

Most viral test kits rely on labor- and time-intensive laboratory preparation and analysis techniques; for example, tests for the novel coronavirus can take days to detect the virus from nasal swabs.

23 Apr 2020

Molecule News and Research

French scientists suggest nicotinic agonists could treat COVID-19

Schizophrenia related to abnormal fatty metabolism in the brain

CNIC researchers develop mouse model to examine the mechanical function of proteins

Researchers discover a new mode of protein degradation by ubiquitin-proteasome system

Research on SARS-CoV-2 spike protein may lead to new vaccines and treatments

Gut microbiota could predict severity of COVID-19

Scientists elucidate novel disease processes involved in pulmonary fibrosis development

Researchers harness the power of AI to accelerate drug discovery

Four drugs that could halt preterm labor identified

Patients with aggressive form of skin cancer can benefit from new type of immunotherapy

Investigational drug may hold benefit for patients with lung and ovarian cancers

Researchers re-purpose cancer-fighting artificial antibodies for COVID-19

Rice University looks to ‘trap and zap’ SARS-CoV-2 in wastewater

Recombinant protein produces neutralizing COVID-19 antibodies in primate model

New brain cell models created to evaluate therapies for Sanfilippo C syndrome

Therapeutic antibody successfully prevents metastases in mice with breast or lung cancer

Scientists are developing synthetic COVID-19 antibody to treat sick patients

Study: JNK and BNP activity can reverse cardiovascular damage, reduce risk of death from sepsis

Graphene-based nanomedicine enables targeted cancer treatment at molecular level

Low-cost, portable detector takes about 30 minutes to identify pathogens

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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