Therapy News and Research

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Current challenges in defining, measuring, and treating MS-related fatigue

Kessler Foundation research scientist John DeLuca, PhD, has published a significant clinical article in Journal of Neurology, shedding light on the elusive nature of fatigue in multiple sclerosis (MS) and its implications for treatment.

7 Aug 2024

New research uncovers mechanisms behind heart damage from CTLA-4 blockade

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a protein receptor on T immune cells that prevents the cells from killing other cells, such as cancer cells.

7 Aug 2024

From discovery to approval: Vorasidenib approved by FDA for treatment of IDH-mutant gliomas

A new drug for treatment of a type of brain cancer, called IDH-mutant low-grade glioma, was approved Aug. 6 by the U.S. Food and Drug Administration (FDA).

7 Aug 2024

Understanding the age gap in leukemia survival rates

Acute lymphoblastic leukemia (ALL) affects both children and adults, but children have better chances to be cured, with long-term survival rates over 85% compared to 50-75% in adults. Scientists at St. Jude Children's Research Hospital conducted a comprehensive study to understand the biological causes driving this difference. The work, published today in the Journal of Clinical Oncology, provides a blueprint for understanding B-cell acute lymphoblastic leukemia (B-ALL), the most common form of the disease.

7 Aug 2024

Study advances understanding of complex neurological disorder

To effectively treat a disease or disorder, doctors must first know the root cause. Such is the case for developmental and epileptic encephalopathies (DEEs), whose root causes can be hugely complex and heterogeneous. Scientists at St. Jude Children's Research Hospital demonstrated the value of DNA methylation patterns for identifying the root cause of DEEs, showing specific gene methylation and genome-wide methylation "episignatures" can help identify the genes that cause DEE. The findings were published today in Nature Communications.

7 Aug 2024

FDA approves vorasidenib for Grade 2 gliomas with IDH mutations

Vorasidenib has been approved by the U.S. Food and Drug Administration (FDA) for patients with Grade 2 gliomas with IDH1 or IDH2 mutations.

6 Aug 2024

Analyzing the impact of heart disease treatments on patients with CHIP

Nicholas A. Marston, MD, MPH, of the TIMI Study Group and Carl J. and Ruth Shapiro Cardiovascular Center at Brigham and Women's Hospital, is the corresponding author of a paper published in Nature Medicine, "Clonal hematopoiesis, cardiovascular events and treatment benefit in 63,700 individuals from five TIMI randomized trials."

6 Aug 2024

High initial drug doses may reduce cancer drug resistance

On July 28, 2024, Mikhail V. Blagosklonny M.D., Ph.D., from Roswell Park Comprehensive Cancer Center published a new editorial in Volume 16, Issue 14 of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), entitled, "Targeted cancer therapy: the initial high concentration may slow down the selection for resistance."

6 Aug 2024

Breakthrough therapy enhances longevity and vitality in aging mice

Everyone wants to live to a ripe old age, but no one wants to be decrepit. Now, University of Connecticut researchers have demonstrated a treatment that could lengthen life - and vigor - up to the very end.

6 Aug 2024

New target identified for melanoma resistant to current therapies

Some proteins, such as programmed cell death protein 1 (PD1), can stop the immune system from attacking cancer cells and, therefore, support the growth of cancer.

6 Aug 2024

Image-guided cancer treatment using biocompatible copper-based nanomaterials

Announcing a new article publication for BIO Integration journal. Cancer is a significant disease that poses a major threat to human health.

6 Aug 2024

Harnessing oncolytic viruses for cancer immunotherapy to improve treatment outcomes

Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target malignant cells while sparing normal tissues.

6 Aug 2024

Expansion of the Mexico-US border wall crossing associated with rising toll of serious injuries

The expansion of the Mexico-US border wall crossing has been accompanied by a rising toll of serious injuries, with poor discharge care and a lack of appropriate interpreting facilities adding up to a "humanitarian and health crisis," suggest researchers in the open access journal Trauma Surgery & Acute Care Open.

6 Aug 2024

MIP Discovery rebrands as Tozaro as it completes transition to supporting cell and gene therapy viral vector analytics and purification

Tozaro’s rationally designed smart polymer affinity reagents offer novel analytics and purification solutions to enhance the development and manufacture of viral vectors in cell and gene therapy.

6 Aug 2024

Study finds long-term cognitive and psychiatric issues persist in COVID-19 patients two to three years post-infection

A recent study investigated whether psychiatric and cognitive symptoms commence or persist beyond a year of COVID-19-related hospitalization.

6 Aug 2024

Menopause myths: Separating fact from fiction

Many women approach menopause with anxiety about the future. You've probably heard your grandmother, mother, or aunts lament about menopause, aka "the change," as a stressful time full of hot flashes, weight gain, and plummeting sex drive.

6 Aug 2024

Valproic acid shows promise in reducing COVID-19 severity and hospitalization

Researchers found that valproic acid (VPA), especially when combined with DHA, significantly reduces SARS-CoV-2 infection rates and severity, potentially activating antiviral mechanisms. Epidemiologic data support VPA's role in reducing COVID-19 severity and hospitalization rates.

6 Aug 2024

Ensuring sustainable and responsible use of AI in healthcare

A new paper highlights the need for responsible and sustainable use of AI in healthcare to mitigate its environmental impact, especially concerning its high carbon footprint. It offers recommendations for reducing energy consumption and improving sustainability practices.

5 Aug 2024

Combining radiation with chemotherapy enhances survival in oligometastatic pancreatic cancer

Researchers from The University of Texas MD Anderson Cancer Center demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy improved progression-free survival (PFS) in patients with oligometastatic pancreatic cancer.

5 Aug 2024

New bioactive material regenerates high-quality cartilage in the knee joints of large-animal model

Northwestern University scientists have developed a new bioactive material that successfully regenerated high-quality cartilage in the knee joints of a large-animal model.

5 Aug 2024

Therapy News and Research

Current challenges in defining, measuring, and treating MS-related fatigue

New research uncovers mechanisms behind heart damage from CTLA-4 blockade

From discovery to approval: Vorasidenib approved by FDA for treatment of IDH-mutant gliomas

Understanding the age gap in leukemia survival rates

Study advances understanding of complex neurological disorder

FDA approves vorasidenib for Grade 2 gliomas with IDH mutations

Analyzing the impact of heart disease treatments on patients with CHIP

High initial drug doses may reduce cancer drug resistance

Breakthrough therapy enhances longevity and vitality in aging mice

New target identified for melanoma resistant to current therapies

Image-guided cancer treatment using biocompatible copper-based nanomaterials

Harnessing oncolytic viruses for cancer immunotherapy to improve treatment outcomes

Expansion of the Mexico-US border wall crossing associated with rising toll of serious injuries

MIP Discovery rebrands as Tozaro as it completes transition to supporting cell and gene therapy viral vector analytics and purification

Study finds long-term cognitive and psychiatric issues persist in COVID-19 patients two to three years post-infection

Menopause myths: Separating fact from fiction

Valproic acid shows promise in reducing COVID-19 severity and hospitalization

Ensuring sustainable and responsible use of AI in healthcare

Combining radiation with chemotherapy enhances survival in oligometastatic pancreatic cancer

New bioactive material regenerates high-quality cartilage in the knee joints of large-animal model

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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