Immune System News and Research

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rVSV-based bivalent vaccine against SARS-CoV-2 delta variant and influenza

Researchers developed four distinct recombinant vesicular stomatitis virus (rVSV)-based bivalent vaccines against SARS-CoV-2 and influenza virus.

22 Dec 2021

Exploring the Mediterranean diet as a potential strategy against SARS-CoV-2

A study found that the Mediterranean diet, when combined with non-smoking and regular physical activity, can lower susceptibility to SARS-CoV-2.

22 Dec 2021

Researchers identify new mechanism that impairs cancer cell proliferation and induces death

UAB and Vall d'Hebron researchers identified the mechanism by which inhibitors of the ERK5 protein kinase impair the proliferation of cancer cells and induce their death. The results, obtained using human cancer cell lines, demonstrate that ERK5 inhibition activates cytotoxic autophagy, a process that triggers cancer cell death, without affecting healthy cells. A combination of ERK5 inhibitors and chemotherapy could improve cancer treatment.

22 Dec 2021

Researchers identify new mechanism for DNA invasion of adenoviral COVID-19 vaccines

Adenoviruses have a linchpin protein that stabilizes their DNA until it reaches the infected cell's nucleus. The protein then detaches from the viral genome, and the virus uncoats. Only then are the genes released into the nucleus, which is necessary for the production of new viruses.

22 Dec 2021

Transcription factor Blimp1 identified as potential target for modulating T-reg activity to treat cancer

In cancer, a major obstacle to anti-tumor immunity and immunotherapy treatment is the infiltration of regulatory T cells, or T-reg cells, into a tumor. These immune cells generally turn down the immune response, and they can prevent the immune system from destroying cancer cells.

22 Dec 2021

Reprogramming immune system cells to strengthen against infections and cancer in geriatric patients

What if the key to aging well lies in reprogramming immune system cells to strengthen them against infections and cancer? Researchers at UT Southwestern are working to find out.

22 Dec 2021

Promising new drug target for TB identified

Mycobacterium tuberculosis (Mtb), the hardy bacterial species that causes tuberculosis (TB), has an unexpected vulnerability that future drugs may be able to exploit, according to a study from researchers at Weill Cornell Medicine.

21 Dec 2021

Severe COVID-19 found to be associated with disrupted intestinal Peyer’s patches

A new study demonstrates significantly altered structure and cellularity of Peyer’s patches in deceased COVID-19 patients.

21 Dec 2021

Understanding SARS-CoV-2-induced systemic amyloidosis

A new study proposed that inflammation combined with aggregates of amyloidogenic peptides of SARS-CoV-2 S proteins might induce systemic amyloidosis.

21 Dec 2021

Identifying a recurring pattern in broadly neutralizing antibodies that can target an epitope on SARS-CoV-2

Interesting research decrypts a recurring sequence in antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) and identifies it to be a board neutralizing antibody that targets a conserved epitope on the SARS-CoV-2 receptor-binding domain (RBD) of the spike protein.

21 Dec 2021

Pandemic poses short- and long-term risks to babies, especially boys

The pandemic has created a hostile environment for pregnant people and their babies. Stress levels among expectant mothers have soared. Pregnant women with covid are five times as likely as uninfected pregnant people to require intensive care and 22 times as likely to die. Infected moms are four times as likely to have a stillborn child.

21 Dec 2021

Study casts light on how to combine antibiotics and phage therapy to fight bacterial infection

New research has moved a step closer to harnessing viruses to fight bacterial infection, reducing the threat of antibiotic resistance.

20 Dec 2021

New study suggests most monoclonal antibody treatments are ineffective against Omicron SARS-CoV-2 variant

The arrival of the Omicron (B.1.1.529) variant has brought into question the effectiveness of current COVID-19 treatments in preventing infection and death. New research published in the preprint bioRxiv* server suggests the efficacy of most monoclonal antibody treatments are ineffective against Omicron.

20 Dec 2021

New Omicron variant may be better at evading vaccine-induced antibodies, research shows

The Omicron variant of SARS-CoV-2 may be significantly better than previous variants at evading vaccine-induced antibodies, according to new research from Cambridge - but preliminary evidence suggests it is less likely to cause severe COVID-19 illness in the lungs.

20 Dec 2021

Lung memory B-cells provide primary protection against SARS-CoV-2 reinfection

Researchers study influenza and SARS-CoV-2 infection models to identify lung memory B cells during viral infection.

20 Dec 2021

Researchers predict 200% increase in European coronavirus cases as Omicron spreads

New algorithms predict how the Omicron variant will spread across 27 countries in the European Union, the United Kingdom, and Switzerland.

20 Dec 2021

A test to identify antibody effectiveness against COVID-19 variants

Since the start of the COVID-19 pandemic, variants have begun to emerge. We spoke to Jacob Heggestad about his rapid test that can detect these variants.

20 Dec 2021

Humanized mice reveals why few COVID-19 cases are more severe than others

Why do 80 to 90% of people infected with COVID-19 experience only mild cases while 10 to 20% face more severe or life-threatening symptoms?

20 Dec 2021

Environmental microbiome's impact on COVID-19 mortality

A new study published on the medRxiv* preprint server was based on the hypothesis that the environmental mycobiome (fungi) is a likely important factor in determining area-level variation in COVID-19 mortality.

19 Dec 2021

Researchers receive CZI grant to support Asian Immune Diversity Atlas project

A team of researchers, led by the Agency for Science, Technology and Research's Genome Institute of Singapore (GIS), was awarded the prestigious Chan Zuckerberg Initiative Ancestry Network Grant in support of their Asian Immune Diversity Atlas (AIDA) project.

18 Dec 2021

Immune System News and Research

rVSV-based bivalent vaccine against SARS-CoV-2 delta variant and influenza

Exploring the Mediterranean diet as a potential strategy against SARS-CoV-2

Researchers identify new mechanism that impairs cancer cell proliferation and induces death

Researchers identify new mechanism for DNA invasion of adenoviral COVID-19 vaccines

Transcription factor Blimp1 identified as potential target for modulating T-reg activity to treat cancer

Reprogramming immune system cells to strengthen against infections and cancer in geriatric patients

Promising new drug target for TB identified

Severe COVID-19 found to be associated with disrupted intestinal Peyer’s patches

Understanding SARS-CoV-2-induced systemic amyloidosis

Identifying a recurring pattern in broadly neutralizing antibodies that can target an epitope on SARS-CoV-2

Pandemic poses short- and long-term risks to babies, especially boys

Study casts light on how to combine antibiotics and phage therapy to fight bacterial infection

New study suggests most monoclonal antibody treatments are ineffective against Omicron SARS-CoV-2 variant

New Omicron variant may be better at evading vaccine-induced antibodies, research shows

Lung memory B-cells provide primary protection against SARS-CoV-2 reinfection

Researchers predict 200% increase in European coronavirus cases as Omicron spreads

A test to identify antibody effectiveness against COVID-19 variants

Humanized mice reveals why few COVID-19 cases are more severe than others

Environmental microbiome's impact on COVID-19 mortality

Researchers receive CZI grant to support Asian Immune Diversity Atlas project

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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