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Study sheds further light on the way APOL1 protein kills trypanosmoe

The African trypanosome Trypanosoma brucei is a blood parasite capable of infecting many mammals. Humans are provided with natural immunity against infection through the activity of the protein apolipoprotein L1 (APOL1): captured via endocytosis, APOL1 forms pores in the lysosomal membrane, leading to the death of the trypanosome.

27 Aug 2015

Two studies highlight important new discovery around most common genetic defect linked to ALS

In today's issue of Nature, two new studies funded in part by The ALS Association both highlight an important new discovery around the C9orf72 mutation, the most common genetic defect associated with amyotrophic lateral sclerosis (ALS).

27 Aug 2015

Researchers reveal new electrical mechanism that can control molecular switches regulating cancer cell growth

The molecular switches regulating human cell growth do a great job of replacing cells that die during the course of a lifetime. But when they misfire, life-threatening cancers can occur. Research led by scientists at The University of Texas Health Science Center at Houston (UTHealth) has revealed a new electrical mechanism that can control these switches.

25 Aug 2015

Esperance, MD Anderson form strategic alliance to accelerate development of anti-cancer candidate EP-100

Esperance Pharmaceuticals Inc. today announced that it has entered into a strategic alliance agreement with MD Anderson Cancer Center to accelerate the clinical development of its lead anti-cancer candidate EP-100 for the treatment of ovarian cancer and to collaborate on preclinical studies of EP-100 as a treatment for breast cancer.

24 Aug 2015

New ASU-POSTECH collaboration aims to discover biological molecules for health care, renewable energy research

The Biodesign Institute at Arizona State University and Pohang University of Science and Technology (POSTECH), Pohang, South Korea, have announced a partnership that will catalyze discoveries with a major impact on health care and clean energy applications.

24 Aug 2015

Novel technique may lead to therapies for pain relief in individuals with intractable pain

A team of scientists at Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) has developed a novel technique using tiny gold rods to target pain receptors.

24 Aug 2015

Study sheds light on helper cells and killer cells

Scientists at the University of Bonn, together with colleagues from the USA and Japan, have shed light on an important immune mechanism. Their work shows how the body provides the important killer cells with a helper in the case of an infection. The study could point the way to better vaccines in the future.

21 Aug 2015

Two proteins that help cells eliminate trash may contribute to development of Parkinson's disease

Two proteins that share the ability to help cells deal with their trash appear to need each other to do their jobs and when they don't connect, it appears to contribute to development of Parkinson's disease, scientists report.

21 Aug 2015

Researchers establish structure of important tumor-suppressing protein

An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN. Their findings provide new insights into how the protein regulates cell growth and how mutations in the gene that encodes the protein can lead to cancer.

21 Aug 2015

Surprising mechanism behind antibiotic resistant bacteria uncovered by TSRI scientists

Every year, more strains of bacteria develop resistance to the antibiotics we use to treat deadly infections. At The Scripps Research Institute (TSRI) scientists have been working to develop new forms of these drugs, including an antibiotic called arylomycin—but tests have shown that it is possible for bacteria to become resistant to arylomycin, too.

20 Aug 2015

caprotec bioanalytics issued U.S. patent for CCMS proteome analysis technology

caprotec bioanalytics GmbH announced today that the United States Patent Office has issued patent No. US9,034,789 covering its revolutionary Capture Compound Mass Spectrometry (CCMS) technology.

20 Aug 2015

Seizures are common but not clinically apparent in newborns after cardiac surgery

In 2011, the American Clinical Neurophysiology Society issued a guideline recommending that neonates undergoing cardiac surgery for repair of congenital heart disease be placed on continuous encephalographic (EEG) monitoring after surgery to detect seizures. These recommendations followed reports that seizures are common in this population, may not be detected clinically, and are associated with adverse neurocognitive outcomes.

20 Aug 2015

Scientists create membrane capable of detecting organisms that trigger diarrhea, intestinal problems

A group of scientists from the Institute of Ecology and the Faculty of Medicine of the National University of Mexico, created a membrane capable of simultaneously detecting numerous organisms in the water or food that cause diarrhea and intestinal problems. This health problem annually kills 760 000 children under the age of five, according to the World Health Organization.

20 Aug 2015

Scientists identify new pathway that may protect brain from Alzheimer's disease

It is a hallmark of Alzheimer's disease: Toxic protein fragments known as amyloid-β clumped together between neurons in a person's brain.

19 Aug 2015

Nuclear process in the brain may play critical role in health and disease

Every brain cell has a nucleus, or a central command station. Scientists have shown that the passage of molecules through the nucleus of a star-shaped brain cell, called an astrocyte, may play a critical role in health and disease.

18 Aug 2015

Reducing amyloid fibril levels in semen may help reduce transmission of HIV

There may be two new ways to fight AIDS -- using a heat shock protein or a small molecule - to attack fibrils in semen associated with the human immunodeficiency virus (HIV) during the initial phases of infection, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

18 Aug 2015

Molecular tweezer blocks HIV, breaks up proteins in semen that boost infection

An unprecedented potential "molecular tweezer" called CLR01, reported in the journal eLife, not only blocks HIV and other sexually transmitted viruses, but also breaks up proteins in semen that boost infection.

18 Aug 2015

Scientists map 3-D atomic structure of protein complex that controls neurotransmitter release from brain cells

Scientists have revealed never-before-seen details of how our brain sends rapid-fire messages between its cells. They mapped the 3-D atomic structure of a two-part protein complex that controls the release of signaling chemicals, called neurotransmitters, from brain cells. Understanding how cells release those signals in less than one-thousandth of a second could help launch a new wave of research on drugs for treating brain disorders.

18 Aug 2015

Neuroscientist discovers how animal's biological clock wakes up, goes to sleep

Fifteen years ago, an odd mutant fruit fly caught the attention and curiosity of Dr. Ravi Allada, a circadian rhythms expert at Northwestern University, leading the neuroscientist to recently discover how an animal's biological clock wakes it up in the morning and puts it to sleep at night.

14 Aug 2015

3D protein structure reveals new drug targets for cancer, neurodegenerative diseases

Protein Kinase C (PKC) is a family of enzymes that controls the activity of other proteins in a cell by attaching chemical tags. That simple act helps determine cell survival or death.

14 Aug 2015

Membrane News and Research

Study sheds further light on the way APOL1 protein kills trypanosmoe

Two studies highlight important new discovery around most common genetic defect linked to ALS

Researchers reveal new electrical mechanism that can control molecular switches regulating cancer cell growth

Esperance, MD Anderson form strategic alliance to accelerate development of anti-cancer candidate EP-100

New ASU-POSTECH collaboration aims to discover biological molecules for health care, renewable energy research

Novel technique may lead to therapies for pain relief in individuals with intractable pain

Study sheds light on helper cells and killer cells

Two proteins that help cells eliminate trash may contribute to development of Parkinson's disease

Researchers establish structure of important tumor-suppressing protein

Surprising mechanism behind antibiotic resistant bacteria uncovered by TSRI scientists

caprotec bioanalytics issued U.S. patent for CCMS proteome analysis technology

Seizures are common but not clinically apparent in newborns after cardiac surgery

Scientists create membrane capable of detecting organisms that trigger diarrhea, intestinal problems

Scientists identify new pathway that may protect brain from Alzheimer's disease

Nuclear process in the brain may play critical role in health and disease

Reducing amyloid fibril levels in semen may help reduce transmission of HIV

Molecular tweezer blocks HIV, breaks up proteins in semen that boost infection

Scientists map 3-D atomic structure of protein complex that controls neurotransmitter release from brain cells

Neuroscientist discovers how animal's biological clock wakes up, goes to sleep

3D protein structure reveals new drug targets for cancer, neurodegenerative diseases

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