Fatigue News and Research

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Alarms could be key to avoiding intraoperative awareness

Bispectral index monitoring is unlikely to be better than monitoring based on anesthetic concentrations for preventing intraoperative awareness, shows a randomized trial.

3 Oct 2012

Improvements to diagnosis and screening of sleep apnea are critical to stroke prevention

Improvements to the diagnosis and screening of sleep apnea are critical to stroke prevention, according to new stroke care guidelines released today at the Canadian Stroke Congress.

3 Oct 2012

Positive results from Noven’s LDMP Phase 3 clinical studies on menopausal VMS

Noven Pharmaceuticals, Inc., a wholly-owned subsidiary of Hisamitsu Pharmaceutical Co., Inc., today announced positive results from two multicenter, double-blind, randomized, placebo-controlled Phase 3 clinical studies evaluating low-dose mesylate salt of paroxetine (LDMP; 7.5 mg/day) for the treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause.

3 Oct 2012

Takeda, Seattle Genetics announce preliminary data from brentuximab vedotin phase I study on sALCL

Millennium: The Takeda Oncology Company, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, and Seattle Genetics, Inc., today announced preliminary data from one arm of a three arm phase I, open-label, multicenter study designed to determine the safety and activity of sequential and combination treatment approaches of brentuximab vedotin with CHOP or CH-P chemotherapy in newly diagnosed patients with CD30-positive mature T- and NK- cell lymphomas.

1 Oct 2012

Exelixis announces interim data from cabozantinib phase 2 trial on metastatic CRPC

Exelixis, Inc. today announced interim data from 51 patients with metastatic castration-resistant prostate cancer (CRPC) and bone metastases receiving a 40 mg daily dose of cabozantinib in an ongoing non-randomized expansion (NRE) cohort of a phase 2 randomized discontinuation trial.

1 Oct 2012

New trial results on pazopanib and temsirolimus have important implications for patients with RCC

New results from phase III trials exploring treatment options for patients with advanced renal cell carcinoma were released at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.

1 Oct 2012

ARIAD announces initial results from AP26113 Phase 1/2 trial on non-small cell lung cancer

ARIAD Pharmaceuticals, Inc. today announced the initial clinical results on its investigational, tyrosine-kinase inhibitor, AP26113, in patients with advanced non-small cell lung cancer (NSCLC) from an ongoing Phase 1/2 trial.

29 Sep 2012

Bayer HealthCare receives FDA approval for Stivarga to treat colorectal cancer

The U.S. Food and Drug Administration today approved Stivarga (regorafenib) to treat patients with colorectal cancer that has progressed after treatment and spread to other parts of the body (metastatic).

28 Sep 2012

Combination of two neuroprotective therapies shows promise against Alzheimer's

The combination of two neuroprotective therapies, voluntary physical exercise, and the daily intake of melatonin has been shown to have a synergistic effect against brain deterioration in rodents with three different mutations of Alzheimer's disease.

27 Sep 2012

KSU creates simple blood test that can accurately detect lung and breast cancer’s early stages

Researchers at Kansas State University have developed a simple blood test that can accurately detect the beginning stages of cancer.

27 Sep 2012

Infants with regulatory behaviors or maternal psychiatric problems may have increased risk of FSS

Functional somatic symptoms (FSS) are physical complaints, such as headaches, pain, fatigue, and dizziness, that cannot be explained medically. These symptoms affect 10-30% of children and adolescents and account for 2-4% of all pediatric doctor visits.

27 Sep 2012

Two tiny RNA molecules play a key role in pathological heart growth and failure

Cardiac stress, for example a heart attack or high blood pressure, frequently leads to pathological heart growth and subsequently to heart failure. Two tiny RNA molecules play a key role in this detrimental development in mice, as researchers at the Hannover Medical School and the Göttingen Max Planck Institute for Biophysical Chemistry have now discovered.

26 Sep 2012

Interleukin-6 could affect hunger and satiety

Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have identified a molecule in the immune system that could affect hunger and satiety. The researchers hope that new treatments for obesity will benefit from this finding.

24 Sep 2012

Patients with chronic obstructive pulmonary disease experience poor sleep quality

Patients with chronic obstructive pulmonary disease (COPD) experience poorer sleep quality than people of a similar age without COPD, according to research published in the journal Respirology.

21 Sep 2012

Thyroid journal publishes new ATA guidelines for diagnosis and treatment of hypothyroidism

The American Thyroid Association (ATA) today announced that new clinical practice guidelines for the diagnosis and treatment of hypothyroidism are published in the current issue of Thyroid.

21 Sep 2012

Complete story behind connection between XMRV virus and prostate cancer

A once-promising discovery linking prostate cancer to an obscure retrovirus derived from mice was the result of an inadvertent laboratory contamination, a forensic analysis of tissue samples and lab experiments - some dating back nearly a decade - has confirmed.

20 Sep 2012

Viral cause excluded for chronic fatigue syndrome

New research suggests that chronic fatigue syndrome does not occur as a result of infection with xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus.

19 Sep 2012

No association between XMRV/pMLV and chronic fatigue syndrome

The causes of chronic fatigue syndrome (CFS) have long eluded scientists. In 2009, a paper in the journal Science linked the syndrome-sometimes called myalgic encephalomyelitis (ME)-to infection with a mouse retrovirus called XMRV (xenotropic murine leukemia virus (MLV)-related virus).

18 Sep 2012

Cognitive basis proposed for fatigue after stroke

Research shows that poststroke fatigue in patients with nondisabling stroke is tied to a specific type of cognitive dysfunction.

17 Sep 2012

Prevalence MRSA laryngitis may be underestimated

Methicillin-resistant Staphylococcus aureus laryngitis may be more common than previously suspected, a new case series suggests.

17 Sep 2012

Fatigue News and Research

Alarms could be key to avoiding intraoperative awareness

Improvements to diagnosis and screening of sleep apnea are critical to stroke prevention

Positive results from Noven’s LDMP Phase 3 clinical studies on menopausal VMS

Takeda, Seattle Genetics announce preliminary data from brentuximab vedotin phase I study on sALCL

Exelixis announces interim data from cabozantinib phase 2 trial on metastatic CRPC

New trial results on pazopanib and temsirolimus have important implications for patients with RCC

ARIAD announces initial results from AP26113 Phase 1/2 trial on non-small cell lung cancer

Bayer HealthCare receives FDA approval for Stivarga to treat colorectal cancer

Combination of two neuroprotective therapies shows promise against Alzheimer's

KSU creates simple blood test that can accurately detect lung and breast cancer’s early stages

Infants with regulatory behaviors or maternal psychiatric problems may have increased risk of FSS

Two tiny RNA molecules play a key role in pathological heart growth and failure

Interleukin-6 could affect hunger and satiety

Patients with chronic obstructive pulmonary disease experience poor sleep quality

Thyroid journal publishes new ATA guidelines for diagnosis and treatment of hypothyroidism

Complete story behind connection between XMRV virus and prostate cancer

Viral cause excluded for chronic fatigue syndrome

No association between XMRV/pMLV and chronic fatigue syndrome

Cognitive basis proposed for fatigue after stroke

Prevalence MRSA laryngitis may be underestimated

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