Clinical Trial News and Research

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SARS-CoV-2 inhibited by pyrimidine biosynthesis inhibitors in conjunction with nucleoside analogs

In an effort to hasten the research on identifying antiviral drugs for SARS-CoV-2 infection, researchers from the U.S. and Switzerland performed extensive drug screening for antiviral activity using live virus infection in human respiratory cells. As a result, they identified a set of possible drug candidates that could potentially be tested in clinical trials.

30 Jun 2021

Scientists outline new target for treating type 2 diabetes

This year marks the 100th anniversary of the discovery of insulin, a scientific breakthrough that transformed Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, from a terminal disease into a manageable condition.

30 Jun 2021

New biomarkers can predict HIV remission after antiretroviral therapy interruption

New biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are critical for the development of new therapeutic strategies that can achieve infection control without ART, a condition defined as functional cure.

29 Jun 2021

Patient-psychotherapist matching improves outcomes of mental health treatment

In first-of-its kind research led by a University of Massachusetts Amherst psychotherapy researcher, mental health care patients matched with therapists who had a strong track record of treating the patients' primary concerns had better results than patients who were not so matched.

29 Jun 2021

Clinical trial demonstrates safety of new approach to treat invasive kidney cancer

A new approach using precisely targeted, high-dose radiation to treat invasive kidney cancer proves safe, based on a clinical trial by the UT Southwestern Harold C. Simmons Comprehensive Cancer Center's kidney cancer program. The study, published in the International Journal of Radiation Oncology*Biology*Physics, could offer new hope for patients with a historically dismal condition.

29 Jun 2021

Face mask mandates reduced COVID-19 case rates, hospitalizations and deaths in Kansas

Despite facing cultural and political pushback, the evidence remains clear: Face masks made a difference in Kansas.

28 Jun 2021

Metabolic activators can reduce recovery time in patients with mild-to-moderate Covid-19

Metabolic activators were found to reduce recovery time by as many as 3.5 days in patients with mild-to-moderate Covid-19, according to a Swedish-British study published today in Advanced Science.

28 Jun 2021

Preliminary results of AAV-mediated gene therapy for Crigler Najjar syndrome

Preliminary results from the European gene therapy trial for Crigler-Najjar syndrome, conducted by Genethon in collaboration with European network CureCN, were presented at the EASL (European Association for the Study of the Liver) annual International Liver Congress on June 26.

28 Jun 2021

Tocilizumab and sarilumab shown to be effective in critical COVID-19

A new study, released as a preprint on the medRxiv* server, describes how a team of researchers from the University Medical Center Utrecht in the Netherlands explored the efficacy of four monoclonal antibodies that antagonize powerful pro-inflammatory pathways. The team sought to determine which were useful in treating critically ill COVID-19 patients on organ support.

28 Jun 2021

An oral pill for COVID-19? Molnupiravir shows promise

Recently, researchers reported molnupiravir as the first oral and direct-acting antiviral that is highly effective at reducing SARS-CoV-2 levels.

27 Jun 2021

Researchers to test early intervention for caregivers of patients with serious illnesses or injuries

An early intervention developed for caregivers of patients with serious illnesses or injuries will be tested by researchers at The University of Texas Health Science Center at Houston.

25 Jun 2021

Mayo Clinic researchers are working toward new CAR-T cell treatment for multiple myeloma

Researchers at Mayo Clinic Cancer Center are studying a potential new chimeric antigen receptor-T cell therapy (CAR-T cell therapy) treatment for multiple myeloma.

25 Jun 2021

Study: A subset of patients with localized prostate cancer may benefit from immunotherapies

In recent years, cancer immunotherapy has been effective in treating patients with immunogenic, or so-called "hot" tumors with increased levels of inflammation and the presence of immune cells in and around the tumors.

24 Jun 2021

Researchers shed light on the microbial connection between very-low-calorie diet and weight loss

Researchers at UCSF have found that extreme caloric restriction diets alter the microbiome in ways that could help with weight loss but might also result in an increased population of Clostridiodes difficile, a pathogenic bacterium that can lead to severe diarrhea and colitis.

24 Jun 2021

Could polio vaccines induce cross-reactive antibodies that target SARS-CoV-2?

A new preprint released on the medRxiv* server explores a link between immunity to SARS-CoV-2, the earlier SARS-CoV, and childhood poliovirus vaccination. Almost 90% of the world’s people have received this vaccine, but antibodies elicited by it reduce over time and are almost absent at the end of adolescence.

24 Jun 2021

FDA issues draft guidance encouraging rational expanded patient eligibility for oncology clinical trials

Today, the FDA issued a draft guidance encouraging industry to include patients with incurable cancers (when there is no potential for cure or for prolonged/near normal survival) in cancer clinical trials, regardless of whether they have received existing alternative treatment options.

24 Jun 2021

Clinical Trial News and Research

SARS-CoV-2 inhibited by pyrimidine biosynthesis inhibitors in conjunction with nucleoside analogs

Scientists outline new target for treating type 2 diabetes

New biomarkers can predict HIV remission after antiretroviral therapy interruption

Patient-psychotherapist matching improves outcomes of mental health treatment

Clinical trial demonstrates safety of new approach to treat invasive kidney cancer

Face mask mandates reduced COVID-19 case rates, hospitalizations and deaths in Kansas

Metabolic activators can reduce recovery time in patients with mild-to-moderate Covid-19

Preliminary results of AAV-mediated gene therapy for Crigler Najjar syndrome

Tocilizumab and sarilumab shown to be effective in critical COVID-19

An oral pill for COVID-19? Molnupiravir shows promise

Researchers to test early intervention for caregivers of patients with serious illnesses or injuries

Mayo Clinic researchers are working toward new CAR-T cell treatment for multiple myeloma

Study: A subset of patients with localized prostate cancer may benefit from immunotherapies

Researchers shed light on the microbial connection between very-low-calorie diet and weight loss

Could polio vaccines induce cross-reactive antibodies that target SARS-CoV-2?

FDA issues draft guidance encouraging rational expanded patient eligibility for oncology clinical trials

Study finds no evidence for remdesivir's benefit in severe COVID-19 patients

New antibody conjugate delivers drugs to bone tumors and inhibits metastasis

Flavoring can change how the brain responds to nicotine e-cigarettes

Cedars-Sinai receives $11.99 million from CIRM to launch ALS clinical trial

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