Proliferation News and Research

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Investigational device to treat brain cancer shows promise in early studies

New early data showed that an investigational device that specifically targets rapidly growing cancer cells with intermediate frequency electrical fields -- called Tumor-Treating Fields (TTFields) -- more than doubled the median overall survival rates in patients with recurrent glioblastoma multiforme (GBM), the most common and aggressive type of malignant brain tumor.

30 May 2007

Detailed portrait of 700 proteins that help maintain DNA integrity

Cells have the remarkable ability to keep track of their genetic contents and -- when things go wrong, to step in and repair the damage before cancer or another life-threatening condition develops.

28 May 2007

Researchers engineer adult stem cells derived from human umbilical cord blood to produce insulin

The researchers announced their laboratory finding, which caps nearly four years of research, in the June 2007 issue of the medical journal Cell Proliferation, posted online this week.

28 May 2007

Link between periodontitis and tongue cancer

Researchers at the University at Buffalo and Roswell Park Cancer Institute have shown for the first time that an association exists between long-standing periodontitis, or gum disease, and risk of tongue cancer.

22 May 2007

Some NSAIDs may be better suited to treating cancer

Until recently, nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and celecoxib (sold as Celebrex), were being hailed as promising cancer prevention drugs.

18 May 2007

Health effects of isoflavones and breast cancer

Are soy products healthy additions to a person's diet, safe alternatives to hormone-replacement therapy or cancer-causing agents" The answer, according to University of Illinois food science and human nutrition professor William Helferich, is, "It depends."

17 May 2007

Culture techniques can significantly affect cell growth and function

When it comes to growing cells in a lab, technique matters. A new Brown University study shows that nerve cells grown in three-dimensional cultures use 1,766 genes differently compared to nerve cells grown in standard two-dimensional petri dishes.

17 May 2007

Radically different approach to nuclear magnetic resonance

Detecting the molecular structure of a tiny protein using nuclear magnetic resonance (NMR) currently requires two things: a million-dollar machine the size of a massive SUV, and a large sample of the protein under study.

16 May 2007

Cells that cause Ewing's sarcoma identified

Inserm researchers at the Institut Curie have identified the cells that cause Ewing’s sarcoma.

16 May 2007

Hepatitis C infection is associated with an increased risk of non-Hodgkin lymphoma

Hepatitis C infection is associated with an increased risk of non-Hodgkin lymphoma (malignancy involving lymphatic tissue) of 20 percent to 30 percent, and a three-fold increase in the risk of another type of lymphoma, according to a study in the May 9 issue of JAMA.

9 May 2007

Cause of gender differences in high blood pressure and related kidney disease

While men and women both get high blood pressure and related kidney disease, the path to get there is shorter, steeper and just different for men, researchers say.

4 May 2007

Phenoxodiol, an investigational drug shows promise for ovarian cancer

A new study further supports the unique mechanism of action of phenoxodiol, an investigational drug being studied for the treatment of ovarian cancer.

2 May 2007

Two-photon absorption imaging of hemoglobin

In an advance that can potentially assist cancer diagnosis, a new optical technique provides high-resolution, three-dimensional images of blood vessels by taking advantage of the natural multiple-photon-absorbing properties of hemoglobin, the red-blood-cell molecule that carries oxygen throughout the bloodstream.

1 May 2007

Leptin shown to significantly influence breast cancer development

Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates.

30 Apr 2007

Small amounts of stem/progenitor cells from bone marrow enhance repair of damaged tissues

New studies in the laboratory of Dr. Darwin J. Prockop, Director of Tulane University's Center for Gene Therapy, are shedding light on the previously mysterious mechanism through which even relatively small amounts of stem/progenitor cells taken from a patient's own bone marrow enhance repair of damaged tissues.

30 Apr 2007

Burnham awarded $7.39 million for study on Neuron-Glia communication in development

A team of researchers at the Burnham Institute for Medical Research (“Burnham”) has been awarded $7.39 million from the National Institute of Child Health and Human Development of the National Institutes of Health.

24 Apr 2007

Neither induced abortion nor miscarriage associated with breast cancer risk in premenopausal women

Neither induced abortion nor spontaneous abortion (miscarriage) appears to be associated with breast cancer risk in premenopausal women, according to a report in the April 23 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

24 Apr 2007

Average U.S. resident is exposed to nearly six times as much radiation from medical devices than in 1980

Data from the first large-scale study of U.S. population radiation exposure since 1989 show the annual per capita radiation dose increased 5.9 times, from 0.54 millisieverts in 1980 to 3.2 millisieverts in 2006.

18 Apr 2007

Avalon Pharmaceuticals announces results of AVN944 biomarker study

Avalon Pharmaceuticals has announced the results of an AVN944 biomarker study that utilized Avalon's proprietary AvalonRx technology to identify gene signatures that may be useful for patient stratification.

18 Apr 2007

Cetuximab improves survival and slows progression of colorectal cancer

Research presented at the 2007 Annual Meeting of the American Association for Cancer Research confirmed that there is now an effective treatment option for colorectal cancer patients for whom all other treatment options have been exhausted, cetuximab.

17 Apr 2007