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Immunotherapy-chemotherapy combo boosts survival for patients with metastatic colorectal cancer

A study led by UCLA Health Jonsson Comprehensive Cancer Center researchers found that using a combination of experimental immunotherapy drugs with chemotherapy significantly improves progression-free survival and overall survival for patients with metastatic colorectal cancer who have previously undergone standard chemotherapy treatment when compared to those who received the targeted therapy regorafenib alone.

24 May 2024

Phase 1 trial for EBC-129 progresses into dose expansion

The Experimental Drug Development Centre (EDDC), Singapore's national platform for drug discovery and development, is pleased to announce that the Phase 1 trial for EBC-129 has progressed into dose expansion.

24 May 2024

New immunogenic strain of vaccinia virus unveils potent cancer therapy potential

Vaccinia viruses are therapeutic tools with different biomedical applications depending on the susceptibility characteristics.

24 May 2024

Psilocybin use initiates hyperconnectivity in the brain linked to ego-modifying effects

A new study shows that the use of psilocybin, a compound found in the widely known "magic mushrooms," initiates a pattern of hyperconnectivity in the brain linked to the ego-modifying effects and feelings of oceanic boundlessness.

23 May 2024

In-vivo imaging to quantify collagen morphology in preclinical melanoma models during immunotherapy

Collagen, a major component of the extracellular matrix, plays a crucial role in tumor development.

23 May 2024

Novel catalog of gene-isoform variation unveiled in the developing human brain

A team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain.

23 May 2024

Study demonstrates causal link between microbial factors and dysfunction of ISCs in colitis

In a study published in Cell Host & Microbe, a research team led by Prof. PAN Wen from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, in collaboration with research teams led by Prof. ZHU Shu and Prof. SONG Xinyang, demonstrated the causal link between microbial factors and dysfunction of intestinal stem cells (ISCs) in colitis.

23 May 2024

New genetic discoveries offer hope for targeted lupus therapies

Lupus is a lifelong, often painful and occasionally lethal autoimmune disease. Few treatments exist today beyond powerful steroids to knock down a patient's immune system - a therapy that has its own serious risks.

23 May 2024

e-QuoL project: Digital tools for young cancer survivors' follow-up care

The "e-QuoL" project will develop a variety of digital tools to assist young cancer survivors manage their health and their follow-up care.

23 May 2024

Study finds no significant survival benefit from participating in cancer clinical trials

Participation in cancer clinical trials often suggests improved survival rates, but high-quality studies accounting for biases show no significant survival benefit. Trial benefits may be overstated due to confounding factors.

23 May 2024

Gene cluster expression analysis for personalized lung cancer therapy

About 30% of lung cancer patients are accessible to targeted therapy or immunotherapy based on the current criteria.

23 May 2024

New chemical modification improves effectiveness and safety of ASO therapy for CNS diseases

Diseases that affect the brain and spinal cord can be particularly devastating, and finding new and more effective ways to treat these conditions is an important goal for researchers and clinicians alike.

23 May 2024

Are step counts as effective as time-based exercise in boosting health?

Monitoring physical activity with either step counts or time spent exercising shows similar benefits in reducing cardiovascular disease and all-cause mortality among women in their 60s. Both methods support health guidelines and personal preference.

23 May 2024

Clomiphene and dexamethasone boost fertility in PCOS patients

Combined clomiphene and dexamethasone treatment improves pregnancy and ovulation rates in PCOS patients, with minimal adverse effects. Further research is needed to optimize dosage and duration.

22 May 2024

New study advocates for de-escalating breast cancer surgery in women aged 55 and older

Surgery involving sentinel lymph node biopsy for middle-aged women with estrogen receptor-positive (ER+) breast cancer may do more harm than good, according to a new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers.

22 May 2024

Dupilumab shows promise in cutting COPD flare-ups and boosting lung function

Dupilumab significantly reduces exacerbations and improves lung function in COPD patients with elevated eosinophil counts, confirming the efficacy of targeting type 2 inflammation.

22 May 2024

Review highlights the rapidly evolving landscape of hepatocellular carcinoma treatment

Hepatocellular carcinoma (HCC), a prevalent form of cancer, profoundly influences the progression and prognosis of the disease through immune response mechanisms.

22 May 2024

Emotional dysregulation identified as core symptom of ADHD

Cambridge scientists have shown that problems regulating emotions – which can manifest as depression, anxiety and explosive outbursts – may be a core symptom of attention deficit hyperactivity disorder (ADHD).

22 May 2024

Biological similarities found between "chemo brain" and brain fog after COVID-19

Brain fog after COVID-19 is biologically similar to cognitive impairment caused by cancer chemotherapy, something doctors often refer to as "chemo brain."

22 May 2024

California pays meth users to get sober

Here in the rugged foothills of California's Sierra Nevada, the streets aren't littered with needles and dealers aren't hustling drugs on the corner.

22 May 2024

Therapy News and Research

Immunotherapy-chemotherapy combo boosts survival for patients with metastatic colorectal cancer

Phase 1 trial for EBC-129 progresses into dose expansion

New immunogenic strain of vaccinia virus unveils potent cancer therapy potential

Psilocybin use initiates hyperconnectivity in the brain linked to ego-modifying effects

In-vivo imaging to quantify collagen morphology in preclinical melanoma models during immunotherapy

Novel catalog of gene-isoform variation unveiled in the developing human brain

Study demonstrates causal link between microbial factors and dysfunction of ISCs in colitis

New genetic discoveries offer hope for targeted lupus therapies

e-QuoL project: Digital tools for young cancer survivors' follow-up care

Study finds no significant survival benefit from participating in cancer clinical trials

Gene cluster expression analysis for personalized lung cancer therapy

New chemical modification improves effectiveness and safety of ASO therapy for CNS diseases

Are step counts as effective as time-based exercise in boosting health?

Clomiphene and dexamethasone boost fertility in PCOS patients

New study advocates for de-escalating breast cancer surgery in women aged 55 and older

Dupilumab shows promise in cutting COPD flare-ups and boosting lung function

Review highlights the rapidly evolving landscape of hepatocellular carcinoma treatment

Emotional dysregulation identified as core symptom of ADHD

Biological similarities found between "chemo brain" and brain fog after COVID-19

California pays meth users to get sober

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How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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