Chimeric Antigen Receptor News and Research

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Study: 39% of B cell lymphoma patients treated with CAR T therapy remain in remission

A new article published today in The Lancet Oncology shows 39 percent of large B cell lymphoma patients treated with the chimeric antigen receptor T-cell therapy Yescarta remained in remission more than two years following therapy, and more than half of the patients treated remain alive.

4 Dec 2018

Scientists use genetically engineered immune cells to fight Hodgkin and non-Hodgkin lymphoma cells

University of North Carolina Lineberger Comprehensive Cancer Center researchers reported promising early results from a clinical study of an investigational cellular immunotherapy that used a patient's own, genetically engineered immune cells to recognize and fight Hodgkin and non-Hodgkin lymphoma cells.

4 Dec 2018

New strategies may improve performance of CAR-T cell therapy in treating cancer

Mayo Clinic researchers have developed two new strategies that may improve the performance of chimeric antigen receptor therapy in treating cancer. They are presenting results of their preclinical research at the 2018 annual meeting of the American Society of Hematology in San Diego.

3 Dec 2018

Study shows outcomes of CAR T-cell therapy when used as standard of care for lymphoma

Chimeric antigen receptor T-cell therapy, or CAR T, was named the 2017 Advance of the Year by the American Society of Clinical Oncology. The FDA approved two CAR T products last year for treatment of adult large B-cell lymphoma based on the exceptional patient outcomes seen in clinical trials.

3 Dec 2018

SSB enters into collaboration with Immunochina to develop new immunotherapy equipment

Sartorius Stedim Biotech, a leading international supplier of the biopharmaceutical industry, through its China affiliate, and Beijing-based Immunochina Pharmaceuticals, announced today that both parties have entered into a collaboration.

3 Dec 2018

Study: 51% of patients alive two years after receiving CAR-T therapy for diffuse large B-cell lymphoma

A follow-up analysis of patients enrolled in a Phase I/II multi-center trial for diffuse large B-cell lymphoma reported 51 percent of patients receiving an anti-CD19 chimeric antigen receptor (CAR T) called axi-cel were still alive two years post-treatment.

3 Dec 2018

IU scientists find toxic flame retardants in children's car seats

In a new study, Indiana University scientists found toxic flame retardants in newly manufactured children's car seats, sparking concerns about children's health. Of the 18 children's car seats tested, 15 contained new or traditional hazardous flame retardant chemicals.

3 Dec 2018

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).

3 Dec 2018

Triple combination cancer immunotherapy improves survival in mouse model of melanoma

Adoptive cell transfer is a promising cancer immunotherapy that involves isolating T cells from cancer patients that are capable of targeting their tumor, selecting the more active T cells and expanding those in the lab, and then transfusing them back into patients.

30 Nov 2018

New study could fine-tune the CRISPR gene editing process

The introduction of the tool for gene editing, the so-called gene scissors CRISPR, in 2007 was a revolution within medical science and cell biology.

30 Nov 2018

First-ever European Meeting on CAR T Cell Therapy represents educational opportunity for healthcare professionals

CAR T Cell Therapy is revolutionizing the field of hematologic malignancies and has the potential to achieve cure for a number of dreadful diseases.

29 Nov 2018

New artificial joint restores natural forearm rotation in amputees

A new artificial joint restores important wrist-like movements to forearm amputees, something which could dramatically improve their quality of life.

28 Nov 2018

Study reveals why mitochondria are often strangely shaped inside the brain

Columbia neuroscientists have discovered why mitochondria, tiny power generators that keep our cells healthy, are often strangely shaped inside the brain.

28 Nov 2018

New study could provide a potential new drug to help fight obesity

Our bodies contain two types of fat: white fat and brown fat. While white fat stores calories, brown fat burns energy and could help us lose weight. Now, scientists at the University of Cambridge have found a way of making the white fat 'browner' and increasing the efficiency of brown fat.

27 Nov 2018

Abramson Cancer Center becomes the 28th member institution of National Comprehensive Cancer Network

The Abramson Cancer Center (ACC) at the University of Pennsylvania announced today that it is joining the National Comprehensive Cancer Network (NCCN) as its 28th member institution.

20 Nov 2018

Person's sex hormones may play key role in trauma survival, finds study

A person's sex hormones may play a role in trauma survival, according to a Kansas State University researcher who has received a $650,000 grant from the U.S. Department of Defense.

16 Nov 2018

With hospitalization losing favor, judges order outpatient mental health treatment

When mental illness hijacks Margaret Rodgers' mind, she acts out. Rodgers, 35, lives with depression and bipolar disorder. When left unchecked, the conditions drive the Alabama woman to excessive spending, crying and mania.

13 Nov 2018

Allied BioScience receives approved label from EPA for new bacteriostatic surface coating

Allied BioScience, a Plano, Texas-based biotechnology company announced today it has received an approved label from the U.S. Environmental Protection Agency for SurfaceWise, a new bacteriostatic surface coating that inhibits the growth of and provides continuous protection against bacteria, fungi and algae which cause odor, staining and discoloration in various commercial settings, including hospitals and sports facilities.

9 Nov 2018

Salk researchers solve genetic 'whodunnit' for cancer gene

Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the long-standing mystery around why AMPK can both hinder and help cancer.

8 Nov 2018

New study sheds light on how CAR T cell therapy works

Cancer remains the second-leading cause of death in the United States. This year, an estimated 1.7 million new cases will be diagnosed, with nearly 610,000 people expected to die from the disease, according to the National Cancer Institute.

8 Nov 2018

Chimeric Antigen Receptor News and Research

Study: 39% of B cell lymphoma patients treated with CAR T therapy remain in remission

Scientists use genetically engineered immune cells to fight Hodgkin and non-Hodgkin lymphoma cells

New strategies may improve performance of CAR-T cell therapy in treating cancer

Study shows outcomes of CAR T-cell therapy when used as standard of care for lymphoma

SSB enters into collaboration with Immunochina to develop new immunotherapy equipment

Study: 51% of patients alive two years after receiving CAR-T therapy for diffuse large B-cell lymphoma

IU scientists find toxic flame retardants in children's car seats

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

Triple combination cancer immunotherapy improves survival in mouse model of melanoma

New study could fine-tune the CRISPR gene editing process

First-ever European Meeting on CAR T Cell Therapy represents educational opportunity for healthcare professionals

New artificial joint restores natural forearm rotation in amputees

Study reveals why mitochondria are often strangely shaped inside the brain

New study could provide a potential new drug to help fight obesity

Abramson Cancer Center becomes the 28th member institution of National Comprehensive Cancer Network

Person's sex hormones may play key role in trauma survival, finds study

With hospitalization losing favor, judges order outpatient mental health treatment

Allied BioScience receives approved label from EPA for new bacteriostatic surface coating

Salk researchers solve genetic 'whodunnit' for cancer gene

New study sheds light on how CAR T cell therapy works

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