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FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

Amgen today announced that the U.S. Food and Drug Administration has approved the supplemental Biologics License Application for the expanded use of ENBREL (etanercept), making it the first and only systemic therapy to treat pediatric patients (ages 4-17) with chronic moderate-to-severe plaque psoriasis.

7 Nov 2016

Researchers create new culture model of human intestine to study inflammatory bowel disease

Inflammatory bowel disease (IBD) is a complex condition that requires a lifetime of care and increases a person's cancer risk.

2 Nov 2016

Alcohol-free berry wine could potentially reduce effects of Type 2 diabetes

Blueberries, and berries in general, are among foods labeled as "diabetes superfoods" by the American Association of Diabetes. Food science researchers at the University of Illinois have found that fermenting berries may improve their antidiabetic potential even more.

1 Nov 2016

Nova Bioprofile FLEX autosampler helps achieve significant productivity improvement via dynamic feeding media optimization

Current industry practices for large-scale mammalian cell cultures typically employ a standard platform fed-batch process with fixed volume bolus feeding. Although widely used, these processes are unable to respond to actual nutrient consumption demands from the culture, which can result in accumulation of by-products and depletion of certain nutrients.

31 Oct 2016

Study shows metabolite concentration can be controlled in bioreactors using OPC enabled BioProfile FLEX analyser

Current initiatives within the biopharmaceutical industry to adopt PAT (Process Analytical Technology) approaches in manufacturing, include activities in early process development.

31 Oct 2016

Small RNA molecules could contribute to serious pregnancy complication, study finds

A family of small RNA molecules affects the development of cells that give rise to the placenta - an organ that transfers oxygen and nutrients from mother to fetus -- in ways that could contribute to a serious pregnancy complication, UT Southwestern Medical Center researchers report.

24 Oct 2016

Scientists discover new option for treating malignant pleural mesothelioma

Researchers at the Comprehensive Cancer Center of MedUni Vienna and Vienna General Hospital have discovered a new option for treating malignant pleural mesothelioma.

24 Oct 2016

Esperite's business unit develops therapy for Crohn's disease perianal fistulas

Esperite's business unit The Cell Factory in collaboration with Women's and Children's Health Department of the University of Padua and the Padua University Hospital are developing therapies for inflammatory bowel disease (IBD) using extracellular vesicles (EVs).

21 Oct 2016

New study raises serious safety concerns in clinical use of caspase inhibitors for liver injury

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase.

20 Oct 2016

NAC improves effectiveness of adoptive cell therapy for treating melanoma

A collaborative team of investigators at the Medical University of South Carolina and Loyola University have demonstrated for the first time that culturing T cells in N-acetyl cysteine (NAC) before they are infused as immunotherapy improves effectiveness and outcomes in a preclinical model of melanoma. These findings were reported in the October 15, 2016 issue of Cancer Research.

17 Oct 2016

GDE2 protein could help predict course of neuroblastoma

The research group of Wouter Moolenaar of the Netherlands Cancer Institute (NKI) has, in collaboration with the group of Rogier Versteeg of the AMC Amsterdam, discovered a protein that can predict the course of neuroblastoma.

4 Oct 2016

Scientists develop new detection system to identify cocaine at low concentrations

Researchers from Valencia and the Basque Country have developed a new method to detect cocaine and mycoplasma at very low concentrations.

3 Oct 2016

New qEV single size exclusion chromatography columns launched by Izon Sciences for analytical scale exosome isolation

Izon Science announces the release and immediate availability of its new analytical-scale exosome isolation column, the qEVsingle

From Izon Science 30 Sep 2016

Researchers reveal how ultrasmall nanoparticles can kill cancer cells

Nanoparticles known as Cornell dots, or C dots, have shown great promise as a therapeutic tool in the detection and treatment of cancer.

29 Sep 2016

Department of Defense funds cardiac cell therapy trial for heart failure patients

Building on the results of a recent Cedars-Sinai Heart Institute study published just six months ago, the Department of Defense has awarded a $10 million grant to fund a cardiac cell therapy trial for patients diagnosed with a common but difficult-to-treat form of heart failure.

28 Sep 2016

New study reveals endocrine biological function of brown adipose tissue

Brown adipose tissue -main organ generating heat in the body- is also an endocrine organ that secretes signaling factors that activate the fat and carbohydrates metabolism.

28 Sep 2016

CHOP researchers exploit gene discovery in severe epilepsy to identify precision treatment

An international team of researchers who discovered a new gene disorder that causes severe childhood epilepsy leveraged that finding to reduce seizures in two children.

20 Sep 2016

BUAP researchers develop biomaterial that can be printed in 3D for regenerating bone tissue

Researchers at the Autonomous University of Puebla (BUAP) developed a biomaterial with the ability to serve as a support for regenerating bone tissue, which is biodegradable and can be printed in 3D with controlled porosity.

13 Sep 2016

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase. Caspase inhibitors have therapeutic potential to treat and prevent apoptosis-mediated liver injury, and some are currently in clinical trials.

9 Sep 2016

JMU scientists crystallize new inhibitory antibodies targeting sclerostin

Osteoporosis particularly affects elderly women: the bone's structure weakens and the risk of suffering fractures rises.

2 Sep 2016