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Researchers study how cancer cells re-organize 3D structure of DNA to ramp up oncogene activity

In cancer, a lot of biology goes awry: Genes mutate, molecular processes change dramatically, and cells proliferate uncontrollably to form entirely new tissues that we call tumors.

10 May 2021

Study discovers harmful inflammatory protein in patients with symptomatic tuberculosis

A pioneering study by UCL scientists has discovered the presence of a harmful inflammatory protein in patients with symptomatic tuberculosis (TB).

10 May 2021

Esophageal cancers turn on ancient viral DNA hidden in our genome

Scientists have discovered that many esophageal cancers turn on ancient viral DNA that was embedded in our genome hundreds of millions of years ago.

10 May 2021

Korea's first large-scale project reaches milestone of sequencing 10,000 whole genomes

On April 26, UNIST and Ulsan City officially announced that their ambitious 10,000 Genome Project has finally reached the milestone of sequencing 10,000 whole genomes.

10 May 2021

Researchers show SARS-CoV-2 genes can be integrated into the human genome

Researchers in the United States have shown that genes from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of coronavirus disease 2019 (COVID-19) – can be integrated into the genome of infected human cells.

10 May 2021

Combo COVID-flu vaccine protects against current and emerging variants in animal model

Now, in new research posted to the bioRxiv preprint server, scientists at Novavax, Inc. present a vaccine including recombinant influenza hemagglutinin (HA) antigen along with recombinant SARS-CoV-2 spike protein, with saponin Matrix-M adjuvant. Both have passed independent safety tests in phase 1 trials.

10 May 2021

Absence of key gene causes severe hearing loss

A gene called GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.

7 May 2021

Researchers identify genetic cause of a rare neurological disorder

In a paper published today in Nature Communications, an international group of collaborators led by researchers at UPMC Children's Hospital of Pittsburgh have identified a genetic cause of a rare neurological disorder marked by developmental delay and loss of coordination, or ataxia.

7 May 2021

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

An interesting new study describes the emergence of several such variants from a chronically immunosuppressed COVID-19 patient, who remained infected for over 170 days before clearing the virus.

7 May 2021

The ancestor of SARS-CoV-2’s Wuhan strain was circulating in late October 2019

The SARS-CoV-2 was first reported in a case from Wuhan, China, in December 2021, and subsequently became the cause of the COVID-19 pandemic that is ravaging the world today. A new study in the journal Molecular Biology and Evolution tracks its variants all over the world since the onset of the pandemic.

7 May 2021

High-throughput system can regulate gene expression for treating sickle cell disease, beta thalassemia

St. Jude Children's Research Hospital scientists have developed an integrated, high-throughput system to better understand and possibly manipulate gene expression for treatment of disorders such as sickle cell disease and beta thalassemia. The research appears today in the journal Nature Genetics.

7 May 2021

Study reports vitamin C inhibits SARS-CoV-2 virus main protease

Based on structural analysis, researchers found that vitamin C binds to 3CLpro, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease essential in viral replication. In vitro cell inhibition studies also showed vitamin C could inhibit 3CLpro, indicating a possible new antiviral treatment method.

6 May 2021

Indian SARS-CoV-2 variant shows enhanced host cell entry and immune evasion

A study conducted by researchers in Germany has found that the B.1.617 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has emerged in India entered certain types of lung and intestine cells with slightly increased efficiency compared with the original wild-type strain.

6 May 2021

Study describes IgG antibodies in Crohn's disease specific for human bacterial flagellins

Last year, Charles O. Elson, M.D., demonstrated a potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease. He used a mouse model that included immune-reactive T cells from patients with Crohn's disease in a flagellin peptide-specific immunotherapy.

6 May 2021

Study reveals a new form of muscular dystrophy associated with pathogenic changes in JAG2 gene

In about a quarter of patients with hereditary diseases, the cause of the disease remains unclear even after extensive genetic testing. One reason is that we still do not know enough about the function of many genes. Of the 30,000 known genes, just a little more than 4,000 have been found to be associated with hereditary diseases.

6 May 2021

Monocytes promote viral control during SARS-COV-2 infection

In a paper recently uploaded to the preprint server bioRxiv by Vanderheiden et al. (May 4th, 2021) the contribution of monocytes in promoting protective immunity from SARS-CoV-2 is investigated in a murine model, suggesting that CCR2 plays the role of an inflammation modulator in early infection.

6 May 2021

Novel pipeline identifies millions of molecular targets in SARS-CoV-2

Researchers in the United States have developed a novel pipeline for high-throughput, automated annotation of the genes, proteins and functional domains in the genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

5 May 2021

Genome News and Research

Researchers study how cancer cells re-organize 3D structure of DNA to ramp up oncogene activity

Study discovers harmful inflammatory protein in patients with symptomatic tuberculosis

Esophageal cancers turn on ancient viral DNA hidden in our genome

Korea's first large-scale project reaches milestone of sequencing 10,000 whole genomes

Researchers show SARS-CoV-2 genes can be integrated into the human genome

Combo COVID-flu vaccine protects against current and emerging variants in animal model

Absence of key gene causes severe hearing loss

Researchers identify genetic cause of a rare neurological disorder

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

The ancestor of SARS-CoV-2’s Wuhan strain was circulating in late October 2019

High-throughput system can regulate gene expression for treating sickle cell disease, beta thalassemia

Study reports vitamin C inhibits SARS-CoV-2 virus main protease

Indian SARS-CoV-2 variant shows enhanced host cell entry and immune evasion

Study describes IgG antibodies in Crohn's disease specific for human bacterial flagellins

Study reveals a new form of muscular dystrophy associated with pathogenic changes in JAG2 gene

Monocytes promote viral control during SARS-COV-2 infection

Novel pipeline identifies millions of molecular targets in SARS-CoV-2

New genetic mutation increases risk for atrial fibrillation, heart failure in Black people

New $10.7 million project aims to study the genetic underpinnings of Alzheimer's disease

Stem cell therapy for COVID-19 and ARDS

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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