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Engineered decoy receptor could protect against coronaviruses

Researchers in the United States have shown that an engineered soluble decoy receptor tightly binds the spike protein of severe acute respiratory syndrome (SARS)-associated viruses. This could potentially provide protection against zoonotic betacoronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

20 Oct 2020

Precision epidemiology could help explain variability in COVID-19 symptoms

Researchers from National Taiwan University have presented a multi-omics view of how mutations in angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) affect infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and progression of coronaviruses disease 2019 (COVID-19).

20 Oct 2020

WSU scientists develop new method to detect Alzheimer's biomarkers

Washington State University scientists have developed a method to detect the biomarkers for Alzheimer's disease that is 10 times more sensitive than current blood testing technology.

20 Oct 2020

NMR Metabolomics as Novel Screening Tool for New-borns (For Research Only)

In this interview, Oscar Millet, group leader of the Precision Medicine and Metabolism group of the CIC bioGUNE, talked to News Medical about his research into the use of nuclear magnetic resonance spectroscopy (NMR) metabolomic analysis as a clinical screening tool. His team has used NMR to screen urine samples form new-borns for congenital metabolic disorders.

From Bruker BioSpin Group 20 Oct 2020

Study helps restore retinal and visual functions of mice models of inherited retinal disease

A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease.

20 Oct 2020

Androgen deprivation strategies could help mitigate SARS-CoV-2 infection

Since the beginning of the COVID-19 pandemic, researchers have noted that women are generally less severely affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This has led to the exploration into estrogen and androgens' role in the hyperinflammatory clinical phenotypes of COVID-19. A recent study published on the preprint server bioRxiv shows that drugs targeting androgens and TMPRSS2 inhibitors may potentially combat the pandemic.

20 Oct 2020

Researchers apply a novel technique to improve understanding of liver disease, immune activation

Human cells are encased by a membrane coated with diverse sugar molecules known as glycans. These glycans play many roles in health and disease, making them important to understand.

20 Oct 2020

Molecular simulations reveal detailed structure and dynamics of SARS-CoV-2 spike protein

Recently, researchers reported a study in which they analyzed the structure and dynamics of the spike protein using multiple molecular dynamic simulations. Their study is published on the preprint server bioRxiv.

19 Oct 2020

Antigenic imprinting of sarbecovirus

A recent study published on the preprint server bioRxiv* in October 2020 shows that the design of a vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) must consider the prior history of exposure to coronaviruses since these affect the antibody response to the virus.

19 Oct 2020

New lab test for detection of SARS-CoV-2 antibodies gives results more quickly than existing assays

Knowing you have developed antibodies against the SARS-CoV-2 virus after recovering from COVID-19 doesn't tell you everything about your immunity.

19 Oct 2020

Study tackles the role of the renin-angiotensin system on COVID-19 pathophysiology

Vinicius Novaes Rocha, a researcher at the Federal University of Juiz de Fora in Brazil, provides an insight into the role of the renin-angiotensin on the pathophysiology of COVID-19, paving the way for developing new treatment methods in the journal Medical Hypotheses.

19 Oct 2020

Scientists discover key enzyme involved in the development of autoimmune diseases

Scientists affiliated with the Center for Research on Inflammatory Diseases (CRID http://crid.fmrp.usp.br), hosted by the University of São Paulo (USP) in Brazil, have discovered that an enzyme involved in key metabolic processes also plays a role in immune cell differentiation and hence in the development of autoimmune diseases.

19 Oct 2020

Temple researchers identify criteria to predict cytokine storm in COVID-19 patients

Like a cold front that moves in, setting the stage for severe weather, coronavirus infection triggers showers of infection-fighting immune molecules - showers that sometimes escalate into a chaotic immune response known as a cytokine storm.

19 Oct 2020

CBD could reduce lung damage caused by COVID-19

One way CBD appears to reduce the "cytokine storm" that damages the lungs and kills many patients with COVID-19 is by enabling an increase in levels of a natural peptide called apelin, which is known to reduce inflammation and whose levels are dramatically reduced in the face of this storm.

19 Oct 2020

Scientists lay out a novel rationale for COVID-19 drug design

American and Polish scientists, reporting Oct. 16 in the journal Science Advances, laid out a novel rationale for COVID-19 drug design - blocking a molecular "scissor" that the virus uses for virus production and to disable human proteins crucial to the immune response.

19 Oct 2020

Obesity changes ACE2 and TMPRSS2 expression in mice: Implications for COVID-19

Researchers studying young obese mice found that expression of ACE2, a receptor in host cells that binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is higher in the lungs and trachea of obese mice. The finding could partly explain why obesity is a high-risk factor for COVID-19.

18 Oct 2020

Researchers use new approach to create replacement biological parts

The eventual creation of replacement biological parts requires fully three-dimensional capabilities that two-dimensional and three-dimensional thin-film bioprinting cannot supply.

16 Oct 2020

Scientists discover a novel antiviral strategy for treating COVID-19

A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, Faculty of Science, and Professor Kwok Yung YUEN, Henry Fok Professor in Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine of the University of Hong Kong (HKU), has discovered a novel antiviral strategy for treatment of COVID-19.

16 Oct 2020

Rapid development of functionally diverse SARS-COV-2 mouse monoclonal antibodies

Now, a recent study published on the preprint server bioRxiv in October 2020 reports the development of a rapid process for generating high-affinity mouse mAbs, and their functional attributes.

16 Oct 2020

Sanofi Translate Bio MRT5500 COVID-19 vaccine shows promise in preclinical trials

The COVID-19 pandemic is threatening to come back in greater intensity during the winter and fall. Faced with this threat, vaccine development efforts are entering a phase of renewed focus, attempting to identify antigens capable of eliciting protective levels of neutralizing antibodies. A new study published on the preprint server bioRxiv* in October 2020 reports on a novel mRNA vaccine candidate's performance in two animal models.

16 Oct 2020

Enzyme News and Research

Engineered decoy receptor could protect against coronaviruses

Precision epidemiology could help explain variability in COVID-19 symptoms

WSU scientists develop new method to detect Alzheimer's biomarkers

NMR Metabolomics as Novel Screening Tool for New-borns (For Research Only)

Study helps restore retinal and visual functions of mice models of inherited retinal disease

Androgen deprivation strategies could help mitigate SARS-CoV-2 infection

Researchers apply a novel technique to improve understanding of liver disease, immune activation

Molecular simulations reveal detailed structure and dynamics of SARS-CoV-2 spike protein

Antigenic imprinting of sarbecovirus

New lab test for detection of SARS-CoV-2 antibodies gives results more quickly than existing assays

Study tackles the role of the renin-angiotensin system on COVID-19 pathophysiology

Scientists discover key enzyme involved in the development of autoimmune diseases

Temple researchers identify criteria to predict cytokine storm in COVID-19 patients

CBD could reduce lung damage caused by COVID-19

Scientists lay out a novel rationale for COVID-19 drug design

Obesity changes ACE2 and TMPRSS2 expression in mice: Implications for COVID-19

Researchers use new approach to create replacement biological parts

Scientists discover a novel antiviral strategy for treating COVID-19

Rapid development of functionally diverse SARS-COV-2 mouse monoclonal antibodies

Sanofi Translate Bio MRT5500 COVID-19 vaccine shows promise in preclinical trials

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

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Advancing degrader and proximity-based drug development

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Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo