Genes News and Research

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Study describes sex-specific genetic variants linked with depression

Depression is widely reported to be more common in women than in men, with women twice as likely to receive a diagnosis than men.

17 Mar 2023

Designer DNA drug could be used to delay paralysis in ALS

In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell.

17 Mar 2023

CRISPR-based genome editing restores the vision of mice with retinitis pigmentosa

Researchers in China have successfully restored the vision of mice with retinitis pigmentosa, one of the major causes of blindness in humans.

17 Mar 2023

Drug combination may reduce the risk of prostate cancer progression, death

TALAPRO-2, a study led by Neeraj Agarwal, MD, FASCO, demonstrated that using TALZENNA, in combination with XTANDI, may reduce the risk of disease progression or death by 37%.

17 Mar 2023

Computational analysis of large genetic datasets reveals rare disease etiologies

Using a new computational approach they developed to analyze large genetic datasets from rare disease cohorts, researchers at the Icahn School of Medicine at Mount Sinai and colleagues have discovered previously unknown genetic causes of three rare conditions: primary lymphedema (characterized by tissue swelling), thoracic aortic aneurysm disease, and congenital deafness.

17 Mar 2023

Loss of a beta cell subset might contribute to type 2 diabetes

Multiple types of beta cells produce insulin in the pancreas, helping to balance blood sugar levels. Losing a particularly productive type of beta cell may contribute to the development of diabetes, according to a new study by Weill Cornell Medicine investigators.

17 Mar 2023

Bacteria require phase separation to thrive in the mammalian gut

The common commensal gut bacterium Bacteroides thetaiotaomicron uses phase separation of the transcription termination factor Rho to colonize and thrive in the mammalian gut, according to a new study in mice.

17 Mar 2023

Does vitamin D play an anti-viral role against SARS-CoV-2?

Researchers screened various compounds for anti-viral properties against SARS-CoV-2.

17 Mar 2023

A novel pan-sarbecovirus vaccine candidate neutralizes Omicron BQ.1.1 and XBB subvariants

Researchers provide evidence that a novel vaccine candidate robustly neutralized SARS-CoV-2 Omicron subvariants BQ.1.1 and XBB.

16 Mar 2023

Scientists develop genetically defined mouse models for multiple myeloma subtypes

A team of scientists led by Martin Janz and Klaus Rajewsky at the Max Delbrück Center has successfully generated genetically defined mouse models for two subtypes of multiple myeloma.

16 Mar 2023

Malfunctioning of novel regulatory brain mechanism may be an early contributor of Alzheimer's disease

Researchers from Drexel University have uncovered a novel regulatory mechanism in the brain that is essential for making the right kinds of proteins that promote healthy brain function, and its malfunctioning may be an early contributor of the development of Alzheimer's disease.

15 Mar 2023

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

A new approach that delivers a "one-two punch" to help T cells attack solid tumors is the focus of a preclinical study by researchers from the Perelman School of Medicine at the University of Pennsylvania.

15 Mar 2023

Cuproptosis-associated ferroptosis genes linked with immune infiltration in atherosclerosis

Announcing a new article publication for Cardiovascular Innovations and Applications journal. In this study, the authors identify cuproptosis-associated ferroptosis genes in the atherosclerosis microarray of the Gene Expression Omnibus (GEO) database and explored hub gene-mediated immune infiltration in atherosclerosis.

15 Mar 2023

Researchers uncover new clue as to how "whole genome doubling" drives cancer

A single cell contains 2-3 meters of DNA, meaning that the only way to store it is to package it into tight coils.

15 Mar 2023

Researchers shine new light on a potential target for the treatment of diabetic nephropathy

The kidneys perform a critical role in the body by removing waste and excess fluid in the form of urine. In a condition known as diabetic nephropathy, complications from diabetes disrupt the ability of the kidneys to function properly.

15 Mar 2023

Researchers design a virus-resistant, more useful E. coli bacteria

In a step forward for genetic engineering and synthetic biology, researchers have modified a strain of Escherichia coli bacteria to be immune to natural viral infections while also minimizing the potential for the bacteria or their modified genes to escape into the wild.

15 Mar 2023

Higher plasma caffeine levels may reduce adiposity and risk of type 2 diabetes

A high blood caffeine level might curb the amount of body fat a person carries and their risk of type 2 diabetes, suggests research published in the open access journal BMJ Medicine.

15 Mar 2023

An emerging target for chronic kidney disease treatment - DNA-PKcs

A recent Nature Communications study suggested that DNA-PKcs could be a potential target for treating chronic kidney disease.

15 Mar 2023

Embryonic stem cells used to recreate thyroid cancer histotypes

A recent Nature Communications study revealed the recapitulating capacity of human embryonic stem cells (hESCs) to elucidate the cellular hierarchy of the thyroid gland. Furthermore, these cells possessed the capacity to reproduce the oncogenic process using the CRISPR-based genetic editing method.

14 Mar 2023

A convergent coexpression approach identifies novel genes associated with autism

The current study analyzes transcriptional convergence across many autism risk genes.

14 Mar 2023

Genes News and Research

Study describes sex-specific genetic variants linked with depression

Designer DNA drug could be used to delay paralysis in ALS

CRISPR-based genome editing restores the vision of mice with retinitis pigmentosa

Drug combination may reduce the risk of prostate cancer progression, death

Computational analysis of large genetic datasets reveals rare disease etiologies

Loss of a beta cell subset might contribute to type 2 diabetes

Bacteria require phase separation to thrive in the mammalian gut

Does vitamin D play an anti-viral role against SARS-CoV-2?

A novel pan-sarbecovirus vaccine candidate neutralizes Omicron BQ.1.1 and XBB subvariants

Scientists develop genetically defined mouse models for multiple myeloma subtypes

Malfunctioning of novel regulatory brain mechanism may be an early contributor of Alzheimer's disease

Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors

Cuproptosis-associated ferroptosis genes linked with immune infiltration in atherosclerosis

Researchers uncover new clue as to how "whole genome doubling" drives cancer

Researchers shine new light on a potential target for the treatment of diabetic nephropathy

Researchers design a virus-resistant, more useful E. coli bacteria

Higher plasma caffeine levels may reduce adiposity and risk of type 2 diabetes

An emerging target for chronic kidney disease treatment - DNA-PKcs

Embryonic stem cells used to recreate thyroid cancer histotypes

A convergent coexpression approach identifies novel genes associated with autism

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