Malignant News and Research

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Cancer breakthrough - first treatment to directly target tumor supply

For the first time, physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City have demonstrated in patients the ability of an antibody to directly target the blood supply of a wide variety of tumors, leaving healthy tissues unharmed.

12 Feb 2007

Expanded endonasal approach surgery removes tumors once deemed to be inoperable

A first-of-its-kind study published in the February issue of the Journal of Neurosurgery: Pediatrics suggests endoscopic brain surgery, pioneered by surgeons at the University of Pittsburgh Medical Center, has the potential to be safer and often more effective than conventional surgery in children with life-threatening conditions.

12 Feb 2007

Combination drug treatment helps beat mesothelioma

People with mesothelioma - a form of cancer associated with asbestos exposure - have a higher survival rate when treated with a combination of two cancer drugs, a large multicenter study finds.

12 Feb 2007

Determinants of disease presentation and outcome during cryptococcosis

CRNS and the Institut Pasteur conducted research in France on patients diagnosed with cryptococcosis which ranks second among fatal opportunistic infections in patients infected by HIV and who are profoundly immunosuppressed.

12 Feb 2007

Changes in breast cancer management

Aggressive research currently underway brings hope of dramatic advances in breast cancer management, according to a new review.

12 Feb 2007

Scientists discover enzym that activates epigenetically silenced genes

For several years now, cancer researchers have been studying a mechanism that contributes to the development of malignant tumors: The cell attaches small molecules containing a carbon atom, called methyl groups, to specific building blocks of DNA, thereby individually switching off the genes thus labeled.

11 Feb 2007

Scientists discover how T-cell leukemia viruses evade defense mechanisms

National Cancer Institute (NCI) scientists have discovered how human T-cell leukemia virus type 1 (HTLV-1), which infects about 20 million people worldwide, evades being held in check by one of the body's natural defense mechanisms.

6 Feb 2007

Bright quantum dots help basic cancer biology studies

Though there is little doubt that nanoscale devices are going to play a critical role in improving cancer detection and treatment over the next five to ten years, nanoparticles are already having a major impact on the way that cancer biologists study the processes that go awry within malignant and metastatic cells.

5 Feb 2007

Peptide vaccine fights off breast tumors with help of bacteria-mimicking agents

With the help of immune system-stimulating molecules that mimic bacterial components, researchers have used a type of cancer vaccine to both delay and prevent breast tumors in mice.

1 Feb 2007

Discovery of pancreatic cancer stem cells could lead to more effective therapies

Scientists in the United States have identified for the first time the stem cells linked to pancreatic cancer.

1 Feb 2007

Second-generation dendrimer disintegrates upon command

Dendrimers, highly branched, spherical polymers, have demonstrated their utility as drug and imaging agent delivery vehicles for use in detecting and treating cancer, with several dendrimer-based agents nearing human clinical trials.

29 Jan 2007

FoxOs shown to be potential new targets for cancer drugs

In an elegant, multiple-gene knockout experiment, a team of Boston scientists has discovered that a trio of molecules, called FoxOs, are fundamentally critical in preventing some cancers, maintaining blood vessel stability, and in keeping blood-forming stem cells healthy.

29 Jan 2007

No clear connection between mobile phone use and brain cancer

According to a study conducted in five Northern European countries, there is no clear connection between mobile phone use and malignant brain tumours.

22 Jan 2007

Nanoparticles from crab shells show promise for drug delivery

Nanoparticles made of chitosan, a naturally occuring polymer isolated from crab and shrimp shells, have shown promise as carriers of anticancer drugs, antitumor genes, and other novel therapeutic agents.

22 Jan 2007

Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles

Researchers at Montana State University have used an engineered form of ferritin, a cage-like iron storage protein, to both synthesize and deliver iron oxide nanoparticles to tumors.

16 Jan 2007

Piolitazone shows promise for preventing brain injury from radiation therapy

Researchers at Wake Forest University School of Medicine are the first to report that in animal studies, a common diabetes drug prevents the memory and learning problems that cancer patients often experience after whole-brain radiation treatments.

10 Jan 2007

A Trojan horse for gliomas

Gliomas are a group of brain tumors where the most common type is also the most aggressive one.

9 Jan 2007

Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme

Glioblastoma multiforme is among the most aggressive and difficult cancers to treat. Now, researchers at Penn State University have shown that a lipid-based nanoparticle, designed to bind to a specific receptor found on malignant brain cells but not healthy ones, improves the potency of a common anticancer drug and slows significantly the growth of glioblastoma in mice.

8 Jan 2007

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice

In the first experiment of its kind, investigators at the Center for Cancer Nanotechnology Excellence Focused on Therapy Response (CCNE-TR), based at Stanford University, have shown that single-walled carbon nanotubes (SWCNTs) wrapped in poly(ethylene glycol), or PEG, can successfully target tumors in living animals.

8 Jan 2007

In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles

In an attempt to determine what factors make one nanoparticle better than another at targeting tumors, a team of investigators in Korea have conducted a systematic tumor-targeting study of a variety of self-assembling nanoparticles.

18 Dec 2006