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Scientists shed light on key immune regulators involved in Alzheimer’s and other disorders of lipid-rich tissues

Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer's and other diseases.

21 Mar 2024

Concomitant pharmacotherapy overcomes immunotherapy challenges in aggressive blood cancer

Researchers at the University of Zurich and the University Hospital Zurich have discovered that a specific mutation in the cancer cells of an aggressive type of blood cancer can prevent novel immunotherapies such as CAR T-cell therapy from working.

21 Mar 2024

Study pinpoints several genetic variants contributing to Alzheimer's disease

Identifying genetic variants and the role they play in predisposing people to Alzheimer's disease can help researchers better understand how to treat the neurodegenerative condition for which there is currently no cure.

21 Mar 2024

Middle age: A critical turning point for brain health and cognition

Review emphasizes the significance of midlife for cognitive trajectories and brain health, advocating for research models that capture non-linear changes to better understand the unique processes occurring during this period.

20 Mar 2024

Investigational gene therapy shows promise for rare childhood neurodegenerative disease

An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well tolerated and showed signs of therapeutic benefit in a clinical trial led by the National Institutes of Health.

20 Mar 2024

Risk factors for serious inflammatory conditions in IBD patients identified

Investigators at Cedars-Sinai have identified risk factors that make inflammatory bowel disease (IBD) patients susceptible to developing serious conditions in other parts of their bodies.

20 Mar 2024

Tailored diet could boost growth in malnourished kids via gut bacteria action

Study demonstrates how microbiota-targeted food (MDCF-2) and the presence of Prevotella copri in the gut can enhance weight gain in malnourished children, offering a novel approach to treating malnutrition through diet and microbiome manipulation.

20 Mar 2024

Researchers develop a cost-effective method to spatially characterize and map brain epigenomes

An estimated one in six people suffer from a brain disorder worldwide, according to the American Brain Foundation.

20 Mar 2024

Genetic test can identify how patients with triple negative early-stage breast cancer will respond to immunotherapy

Researchers have developed a genetic test that can identify how patients with triple negative early-stage breast cancer will respond to immunotherapy drugs.

20 Mar 2024

Routine genomic surveillance at antenatal care can be a cost-effective approach to detect changes in malaria transmission

Genetic diversity of the malaria parasite in pregnant women and children declined in an area targeted for malaria elimination in Mozambique, according to a study led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by "la Caixa" Foundation and the Manhiça Health Research Centre (CISM).

20 Mar 2024

Immune cell protein identified as potential target for rare liver cancer treatment

Fibrolamellar carcinoma (FLC) is a rare liver cancer with a poor prognosis if not addressed early with surgery. The disease is caused by a single genetic mutation that creates a fusion protein.

20 Mar 2024

E-cigarette users experience similar DNA changes to specific cheek cells as smokers

E-cigarette users with a limited smoking history experience similar DNA changes to specific cheek cells as smokers, finds a new study led by researchers at UCL (University College London) and University of Innsbruck.

20 Mar 2024

Study highlights causal associations between gut microbes and hypothyroidism

The association between the microbial community of the gut and hypothyroidism.

20 Mar 2024

Understanding schizophrenia through genetics and neural pathways

Our understanding of schizophrenia has increased greatly in recent years, as studies of large groups of people have identified a multitude of genetic variants that increase a person's risk of the disease.

19 Mar 2024

Lower income and education levels increase risk of alcohol-related medical conditions

Men and women with lower income or education levels are more likely to develop medical conditions related to alcohol abuse compared to similar individuals with a higher socioeconomic status.

19 Mar 2024

NUS study reveals key mechanisms behind drug resistance in relapsed acute myeloid leukemia

Scientists from the National University of Singapore (NUS) have discovered that the evasion of apoptosis is a key driver of drug resistance in patients with relapsed acute myeloid leukaemia (AML), a type of aggressive blood cancer.

19 Mar 2024

Decoding the cryptic connection between the brain's architecture and our consciousness

Imagine an alien spacecraft landing on Earth, a mysterious entity unlike anything ever seen before. Now, envision our brain as an intricate spaceship, and the researchers in the COST Action The neural architecture of consciousness (NeuralArchCon) as brilliant engineers determined to crack its inner workings.

19 Mar 2024

Genetic News and Research

Scientists shed light on key immune regulators involved in Alzheimer’s and other disorders of lipid-rich tissues

Concomitant pharmacotherapy overcomes immunotherapy challenges in aggressive blood cancer

Study pinpoints several genetic variants contributing to Alzheimer's disease

Middle age: A critical turning point for brain health and cognition

Investigational gene therapy shows promise for rare childhood neurodegenerative disease

Risk factors for serious inflammatory conditions in IBD patients identified

Tailored diet could boost growth in malnourished kids via gut bacteria action

Researchers develop a cost-effective method to spatially characterize and map brain epigenomes

Genetic test can identify how patients with triple negative early-stage breast cancer will respond to immunotherapy

Routine genomic surveillance at antenatal care can be a cost-effective approach to detect changes in malaria transmission

Immune cell protein identified as potential target for rare liver cancer treatment

E-cigarette users experience similar DNA changes to specific cheek cells as smokers

Study highlights causal associations between gut microbes and hypothyroidism

Understanding schizophrenia through genetics and neural pathways

Lower income and education levels increase risk of alcohol-related medical conditions

NUS study reveals key mechanisms behind drug resistance in relapsed acute myeloid leukemia

Decoding the cryptic connection between the brain's architecture and our consciousness

A blueprint for personality change: Key mechanisms and stability forces

Genetic key to milder COVID: Certain genes slash severity and death risk in older men

Discovering the on-switch for rare genetic inflammatory diseases

Sequencing & Genomics: Elevating Science and Healthcare eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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