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Gene-editing is more error-prone than thought, new findings suggest

The standard gene-editing tool, CRISPR-Cas9, frequently produces a type of DNA mutation that ordinary genetic analysis misses, claims new research published in the journal Proceedings of the National Academy of Sciences.

26 Feb 2020

Scientists discover new biological mechanism of insulin signaling

In a discovery that may further the understanding of diabetes and human longevity, scientists at Scripps Research have found a new biological mechanism of insulin signaling.

25 Feb 2020

Small molecules may open the door to new therapies for Duchenne muscular dystrophy

Researchers identified a group of small molecules that may open the door to developing new therapies for Duchenne muscular dystrophy, an as-yet-uncured disease that results in devastating muscle weakening and loss.

24 Feb 2020

Guiding nanoparticles directly to the tumor cells

Modern anticancer therapies aim to attack tumor cells while sparing healthy tissue. An interdisciplinary team of researchers at Helmholtz-Zentrum Dresden-Rossendorf and FU Berlin has made important progress in this area: the scientists have produced tiny nanoparticles that are designed to specifically target cancer cells.

24 Feb 2020

Scientific breakthrough provides insights into basic mechanisms of allergic reactions

An international research team has been able to describe the overall structure of the antibody type IgE, which is the key molecule in allergic diseases.

24 Feb 2020

Researchers develop new probe to detect common target of anti-inflammatory drugs

The Chan group at the Beckman Institute for Advanced Science and Technology has recently developed a probe named CoxFluor, which is able to distinguish between Cyclooxygenase-2, an enzyme that plays a major role in driving the progression of cancer, and Cyclooxygenase-1, which is expressed in all cells.

23 Feb 2020

Comprehensive tumor profiling reveals why osteosarcoma does not respond to immunotherapy

Comprehensive profiling of tumor samples taken from patients with osteosarcoma shows that multiple factors contribute to the traditionally poor responses observed from treatment with immune checkpoint inhibitors, according to new research from The University of Texas MD Anderson Cancer Center.

22 Feb 2020

Study shows what drives an ordered row of alternating peptides

A team of researchers has verified that it is possible to engineer two-layered nanofibers consisting of an ordered row of alternating peptides, and has also determined what makes these peptides automatically assemble into this pattern.

20 Feb 2020

Scientists make important discovery with implications for people living with AMD

Scientists from Trinity College Dublin have made an important discovery with implications for those living with a common, debilitating eye disease (age-related macular degeneration, AMD) that can cause blindness.

20 Feb 2020

Global study shows long-term survival benefit for a subset of patients with advanced lung cancer

According to the results of a large, global study led by Yale Cancer Center researchers, even a tiny amount of a biomarker known as PD-L1 (programmed death-ligand1) can predict a long-term survival benefit from using pembrolizumab (Keytruda).

20 Feb 2020

Artificial Intelligence brings a novel antibiotic compound

Researchers from the Massachusetts Institute of Technology (MIT) have made a scientific breakthrough where their machine-learning algorithm or Artificial Intelligence (AI) program successfully created a novel antibiotic compound. The drug has since then been tested on deadly bacteria in the lab, and in lab mice with a considerable amount of success, explain the researchers. The study results appear in the latest issue of the journal Cell.

20 Feb 2020

MD Anderson collaborates with Denali Therapeutics to advance novel therapies for neurodegenerative diseases

The University of Texas MD Anderson Cancer Center today announced a strategic research collaboration with Denali Therapeutics Inc. to develop novel therapies for Alzheimer's and other neurodegenerative diseases.

20 Feb 2020

Vaccine for COVID-19 coronavirus could soon be a reality

A team of researchers from the University of Texas at Austin and the National Institutes of Health have managed to make significant progress in the development of a vaccine against the fast-spreading and virulent COVID-19/Novel coronavirus that started in Wuhan, Hubei province of China in December 2019 and is still infecting thousands.

19 Feb 2020

How malaria evades the body’s immune response

Malaria is a life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes. In 2018, there were over 200 million cases of malaria worldwide. Now, a team of researchers found evidence that the malaria parasite can detect a molecule released by approaching immune cells, using it to protect itself and evade the attack by the body’s immune system.

19 Feb 2020

UCLA study finds new way for tracking treatment of rare liver disease in children

UCLA researchers who previously found that intravenous administration of fish oil can treat a rare but potentially deadly form of liver disease in children have now monitored levels of a small molecule at the center of the disorder to track treatment results.

19 Feb 2020

Supersensitive nanomaterials hold promise for DNA analysis and next-generation drugs

In 1900, German physician Paul Ehrlich came up with the notion of a "magic bullet." The basic idea is to inject a patient with smart particles capable of finding, recognizing, and treating a disease. Medicine has pursued the magic bullet ever since.

19 Feb 2020

UCLA researchers identify new molecule that promotes airway health

A molecule identified by UCLA researchers helps maintain a healthy balance of cells in airway and lung tissue.

18 Feb 2020

Potential method for better treatment of premature babies

A new study published in the journal Immunology in February 2020 reports the discovery of a process that occurs in the body naturally, but which enhances the production of type 3 innate lymphoid cells (ILCs) in the lung alveoli of premature babies. These are sentinel cells that keep the mucosal surfaces clean and healthy. They are crucial to building resistance to infection within the human body.

18 Feb 2020

Live-cell imaging provides new insights into dynamic structure of mitochondria

As power plants and energy stores, mitochondria are essential components of almost all cells in plants, fungi and animals. Until now, it has been assumed that these functions underlie a static structure of mitochondrial membranes.

18 Feb 2020

Research suggests new approach to block tau pathology in FTLD, Alzheimer's

The protein β-arrestin-2 increases the accumulation of neurotoxic tau tangles, a cause several forms of dementia, by interfering with removal of excess tau from the brain, a new study by the University of South Florida Health Morsani College of Medicine found.

17 Feb 2020

Molecule News and Research

Gene-editing is more error-prone than thought, new findings suggest

Scientists discover new biological mechanism of insulin signaling

Small molecules may open the door to new therapies for Duchenne muscular dystrophy

Guiding nanoparticles directly to the tumor cells

Scientific breakthrough provides insights into basic mechanisms of allergic reactions

Researchers develop new probe to detect common target of anti-inflammatory drugs

Comprehensive tumor profiling reveals why osteosarcoma does not respond to immunotherapy

Study shows what drives an ordered row of alternating peptides

Scientists make important discovery with implications for people living with AMD

Global study shows long-term survival benefit for a subset of patients with advanced lung cancer

Artificial Intelligence brings a novel antibiotic compound

MD Anderson collaborates with Denali Therapeutics to advance novel therapies for neurodegenerative diseases

Vaccine for COVID-19 coronavirus could soon be a reality

How malaria evades the body’s immune response

UCLA study finds new way for tracking treatment of rare liver disease in children

Supersensitive nanomaterials hold promise for DNA analysis and next-generation drugs

UCLA researchers identify new molecule that promotes airway health

Potential method for better treatment of premature babies

Live-cell imaging provides new insights into dynamic structure of mitochondria

Research suggests new approach to block tau pathology in FTLD, Alzheimer's

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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