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Small molecule discovery offers hope for treatment of Angelman syndrome

Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities.

8 Jul 2024

Nonimaging self-report tool effectively predicts coronary atherosclerosis

Researchers assessed whether non-imaging data could be used to identify people with coronary atherosclerosis.

8 Jul 2024

Scientists identify over 5000 high-risk cancer gene variants

Over 5,000 genetic variants that enable certain cancers to thrive have been identified by scientists, along with a potential therapeutic target to treat or even prevent these cancers from developing.

8 Jul 2024

Neuromuscular training reduces chemotherapy-induced neuropathy and improves patient outcomes

Researchers found that neuromuscular training significantly reduces the incidence and severity of chemotherapy-induced peripheral neuropathy, improving patient quality of life and treatment outcomes.

7 Jul 2024

Phages use selfish DNA to outmaneuver competitors

Curious bits of DNA tucked inside genomes across all kingdoms of life historically have been disregarded since they don't seem to have a role to play in the competition for survival.

5 Jul 2024

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using synthetic lethal strategy for the treatment of solid tumors.

5 Jul 2024

Regulatory and psychological considerations of CGM use in people not living with diabetes

A new narrative review led by researchers at UCL and Birmingham Children's Hospital has found there is a lack of evidence to demonstrate the effective use of continuous glucose monitors (CGMs) in people not living with diabetes (PNLD).

5 Jul 2024

Baby boys more likely to achieve HIV cure or remission after in-utero infection

Baby girls are more likely to acquire HIV from their mothers during pregnancy or childbirth than infant boys, who are conversely more likely to achieve cure or remission, researchers say in a new study that sheds light on the gender differences in immune systems.

5 Jul 2024

Exploring PRM-A as a novel glycan-targeted therapy for SARS-CoV-2 inhibition

HIV, Ebola and most recently, COVID-19 viruses have had an enormous impact on our societies world-wide.

4 Jul 2024

Turning cancer cells against themselves to overcome drug resistance

Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind.

4 Jul 2024

Study suggests gastric bypass can reduce cardiovascular disease risk, irrespective of weight loss

Researchers investigated whether Roux-en-Y gastric bypass reduces cardiovascular risk factors independent of calorie restriction and weight loss.

4 Jul 2024

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy

Researchers found that KLF15 is crucial for maintaining white adipocyte properties in subcutaneous fat, and its deletion induces beige adipocyte characteristics, suggesting new obesity treatment pathways.

4 Jul 2024

Monocyte signature predicts dexamethasone response in severe COVID-19 patients

Dexamethasone is one of the most important drugs in the treatment of severe COVID-19, but patients respond very differently to the therapy.

3 Jul 2024

Protein nanocages: A promising frontier in mRNA therapeutics

In recent years, messenger RNA (mRNA) has emerged as a promising avenue for accurate and potent therapeutic interventions. Unlike DNA drugs, mRNA can express genetic information without the risk of integrating into the host genome.

3 Jul 2024

Beyond PMS: A poorly understood disorder means periods of despair for some women

For the most part, Cori Lint was happy. She worked days as a software engineer and nights as a part-time cellist, filling her free hours with inline skating and gardening and long talks with friends.

3 Jul 2024

Digital screening for depression: Does automated feedback help?

The efficacy of two versions of automated feedback following internet-based depression screening on the severity of depression.

3 Jul 2024

New hope for solid tumors with enhanced CAR-T cells

A promising therapy that treats blood cancers by harnessing the power of the immune system to target and destroy cancer cells could now treat solid tumors more efficiently. Thanks to a recent study published in Molecular Therapy – Methods & Clinical Development from Dan Cappabianca and Krishanu Saha at the Wisconsin Institute for Discovery, Chimeric Antigen Receptor (CAR) T-cell therapy can be improved by altering the conditions the T cells are grown in. And it was all discovered by chance.

3 Jul 2024

New HIV test targets neglected strains in global cure hunt

A multinational team led by Weill Cornell Medicine investigators developed a test that will help measure the persistence of HIV in people affected by viral strains found predominantly in Africa - a vital tool in the search for an HIV cure that will benefit patients around the world.

3 Jul 2024

RNA splicing modulation as a precision approach for neuroendocrine cancer treatment

Neuroendocrine tumors, including small cell lung cancer and neuroendocrine prostate cancer, are very aggressive with high chances of spreading.

2 Jul 2024

Study links vegetable protein to delayed puberty through gut microbiome changes

A large Chinese study found that high vegetable protein intake is linked to later puberty timing and beneficial gut microbiome changes in children, while high animal protein intake is associated with earlier puberty. The gut microbiome mediates these effects.

2 Jul 2024

Therapy News and Research

Small molecule discovery offers hope for treatment of Angelman syndrome

Nonimaging self-report tool effectively predicts coronary atherosclerosis

Scientists identify over 5000 high-risk cancer gene variants

Neuromuscular training reduces chemotherapy-induced neuropathy and improves patient outcomes

Phages use selfish DNA to outmaneuver competitors

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Regulatory and psychological considerations of CGM use in people not living with diabetes

Baby boys more likely to achieve HIV cure or remission after in-utero infection

Exploring PRM-A as a novel glycan-targeted therapy for SARS-CoV-2 inhibition

Turning cancer cells against themselves to overcome drug resistance

Study suggests gastric bypass can reduce cardiovascular disease risk, irrespective of weight loss

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy

Monocyte signature predicts dexamethasone response in severe COVID-19 patients

Protein nanocages: A promising frontier in mRNA therapeutics

Beyond PMS: A poorly understood disorder means periods of despair for some women

Digital screening for depression: Does automated feedback help?

New hope for solid tumors with enhanced CAR-T cells

New HIV test targets neglected strains in global cure hunt

RNA splicing modulation as a precision approach for neuroendocrine cancer treatment

Study links vegetable protein to delayed puberty through gut microbiome changes

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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