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Experts advise against universal genomic screening of newborns

In a new report, experts at The Hastings Center advise against genomic screening of newborns, despite it's potential for providing life long personalized care.

16 Aug 2018

Report discusses whether all newborns should undergo genetic sequencing

As the cost of genome sequencing decreases, researchers and clinicians are debating whether all newborns should be sequenced at birth, facilitating a lifetime of personalized medical care.

16 Aug 2018

Tufts researchers win grant to study integration of genomic sequencing into neonatal care

Tufts Medical Center researchers have received a five-year grant award for more than $8 million from the National Center For Advancing Translational Sciences of the National Institutes of Health to study the integration of targeted genomic sequencing into neonatal diagnosis and care.

16 Aug 2018

New genome analysis could identify people at higher risk of common deadly diseases

A research team at the Broad Institute of MIT and Harvard, Massachusetts General Hospital (MGH), and Harvard Medical School reports a new kind of genome analysis that could identify large fractions of the population who have a much higher risk of developing serious common diseases, including coronary artery disease, breast cancer, or type 2 diabetes.

13 Aug 2018

Altered nitrogen metabolism may contribute to emergence of new cancer mutations

Nitrogen is a basic building block of all the body's proteins, RNA and DNA, so cancerous tumors are greedy for this element. Researchers at the Weizmann Institute of Science, in collaboration with colleagues from the National Cancer Institute and elsewhere, have now shown that in many cancers, the patient's nitrogen metabolism is altered, producing detectable changes in the body fluids and contributing to the emergence of new mutations in cancerous tissue.

13 Aug 2018

New test predicts the risk of serious disease months before symptoms appear

Researchers have developed a new genetic test that can identify people who are at an increased risk of serious disease, long before they develop any symptoms.

13 Aug 2018

Scientists pinpoint the cause of a rare childhood seizure disorder

Scientists have developed a set of computational tools that pinpoint the cause of Early Infantile Epileptic Encephalopathy (EIEE), a rare childhood disorder.

13 Aug 2018

Researchers describe underlying mechanisms of congestive heart failure

Congestive heart failure is a terminal disease that affects nearly 6 million Americans. Yet its management is limited to symptomatic treatments because the causal mechanisms of congestive heart failure -- including its most common form, ischemic cardiomyopathy -- are not known.

10 Aug 2018

Scientists find genetic marker that indicates a person's risk for tachycardia-induced cardiomyopathy

Scientists in Japan have found a potential marker to identify which people with abnormally fast heartbeats are at high risk of developing heart failure.

9 Aug 2018

Study identifies key role of TLK1 and TLK2 enzymes in DNA replication

During cell growth, cells copy their DNA through a process called DNA replication. For this process to be accurate, the genetic and epigenetic information must be copied flawlessly.

9 Aug 2018

ETH scientists discover new cancer-specific molecular changes in tumor tissues

A research team led by Gunnar Raetsch, Professor of Biomedical Informatics at ETH Zurich, has evaluated the largest set of genetic data in cancer medicine: The Cancer Genome Atlas in the United States.

9 Aug 2018

RNA and DNA sequencing platform matches broader swath of drugs to late-stage cancer patients

A comprehensive RNA and DNA sequencing platform benefits late-stage and drug-resistant multiple myeloma patients by determining which drugs would work best for them, according to results from a clinical trial published in JCO Precision Oncology in August.

9 Aug 2018

Blood-based test accurately identifies lung cancer patients who could benefit from immunotherapies

Researchers at UC Davis, Genentech and Foundation Medicine are the first to show that a blood-based test to assess tumor mutational burden accurately identifies non-small cell lung cancer (NSCLC) patients who could benefit from immunotherapies called checkpoint inhibitors.

7 Aug 2018

Researchers identify new regulator in breast cancer cells

Triple-negative breast cancer is a particularly aggressive form of breast cancer. Here, important receptors are missing, which often serve as targets for treatments.

6 Aug 2018

Claudia Langenberg wins Helmholtz International Fellow Award

"Claudia Langenberg is known for her research on genetic causes of insulin resistance, type 2 diabetes and related metabolic disorders," explains Dr. Gabi Kastenmüller, acting head of the Institute of Bioinformatics and Systems Biology.

3 Aug 2018

Genome-wide association study identifies 151 genes for atrial fibrillation

Drawing on genomic data from more than one million individuals, researchers from the University of Michigan have led a large collaborative effort to discover as-yet unknown genetic risk factors for atrial fibrillation: an irregular, often rapid heart rate affecting millions of Americans and more than 30 million people worldwide.

3 Aug 2018

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution.

2 Aug 2018

MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

A Massachusetts General Hospital research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma - the second most common bone cancer in children and young adults - unleashes tumor growth.

2 Aug 2018

Mushrooms from the Far East area could be used to design novel anti-cancer drugs

Mushrooms from the Far East area contain the natural chemical compounds, which could be used for the design of the novel drugs with highly specific anti-tumor activities and low-toxicity.

2 Aug 2018

Nalco Water's molecular-based test for Legionella provides much faster results than current methods

Nalco Water, an Ecolab company, has introduced a molecular-based test for Legionella that provides results 14-times faster than current culture testing methods to help building and cooling tower operators manage public health risks from the waterborne pathogen.

2 Aug 2018

Genomic News and Research

Experts advise against universal genomic screening of newborns

Report discusses whether all newborns should undergo genetic sequencing

Tufts researchers win grant to study integration of genomic sequencing into neonatal care

New genome analysis could identify people at higher risk of common deadly diseases

Altered nitrogen metabolism may contribute to emergence of new cancer mutations

New test predicts the risk of serious disease months before symptoms appear

Scientists pinpoint the cause of a rare childhood seizure disorder

Researchers describe underlying mechanisms of congestive heart failure

Scientists find genetic marker that indicates a person's risk for tachycardia-induced cardiomyopathy

Study identifies key role of TLK1 and TLK2 enzymes in DNA replication

ETH scientists discover new cancer-specific molecular changes in tumor tissues

RNA and DNA sequencing platform matches broader swath of drugs to late-stage cancer patients

Blood-based test accurately identifies lung cancer patients who could benefit from immunotherapies

Researchers identify new regulator in breast cancer cells

Claudia Langenberg wins Helmholtz International Fellow Award

Genome-wide association study identifies 151 genes for atrial fibrillation

Scientists map regulatory landscape of mouse genome at single-cell resolution

MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

Mushrooms from the Far East area could be used to design novel anti-cancer drugs

Nalco Water's molecular-based test for Legionella provides much faster results than current methods

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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