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Scientists uncover link between backup pathogen-fighting system and mutations in Crohn's patients

Genes that regulate a cellular recycling system called autophagy are commonly mutated in Crohn's disease patients, though the link between biological housekeeping and inflammatory bowel disease remained a mystery. Now, researchers at UT Southwestern Medical Center have uncovered an intriguing clue.

28 Jul 2017

Study identifies key component that allows deadly bacteria to spread antibiotic resistance

Antibiotic resistance of the bacterium Staphylococcus aureus is responsible for 11,300 deaths a year in the United States alone -- a figure that corresponds to half of all deaths caused by gram-positive resistant bacteria in that country.

26 Jul 2017

New compound takes positive step toward creating drug for melanoma

While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both mice and on human cells in a petri dish takes a positive step toward creating a drug that can kill melanoma cancer cells without harming nearby healthy cells.

26 Jul 2017

Gene's position on chromosome influences mutations, study shows

Genes do not exist in isolation. Like beads on a string, they sit next to each other on long DNA molecules called chromosomes.

25 Jul 2017

African-American patients have increased gene mutations in tobacco-related tumors, study finds

African-Americans typically have worse outcomes from smoking-related cancers than Caucasians, but the reasons for this remain elusive. However, scientists at Wake Forest Baptist Medical Center have taken a big step toward solving this puzzle.

25 Jul 2017

Preclinical study demonstrates efficacy of gene therapy in treatment of Duchenne muscular dystrophy

Researchers from Genethon, the AFM-Telethon laboratory, Inserm (UMR 1089, Nantes) and the University of London (Royal Holloway) demonstrated the efficacy of an innovative gene therapy in the treatment of Duchenne muscular dystrophy.

25 Jul 2017

New map may be first step to developing treatments for complex brain disorders

Just as parents are not the root of all their children's problems, a single gene mutation can't be blamed for complex brain disorders like autism, according to a Keck School of Medicine of USC neuroscientist.

25 Jul 2017

New way of producing flu vaccine could provide better protection against infection

A new way of producing the seasonal flu vaccine could speed up the process and provide better protection against infection.

24 Jul 2017

Wistar scientists discover new therapeutic strategy for difficult-to-treat form of ovarian cancer

A potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer has been discovered by Wistar scientists. The findings were published online in Nature Cell Biology.

24 Jul 2017

Study provides deeper understanding into genetic basis of neuropsychiatric disorders

A study by scientists at the Children's Medical Center Research Institute at UT Southwestern is providing insight into the genetic basis of neuropsychiatric disorders.

21 Jul 2017

Wayne State researchers receive $1.9 million NIH grant to better understand rare genetic disorders

A team of Wayne State University researchers recently received a $1.9 million grant from the National Eye Institute of the National Institutes of Health to better understand leukodystrophies (LD) and genetic Leukoencephalopathies (gLE), rare genetic disorders affecting the white matter -- myelin -- in the central nervous system.

21 Jul 2017

New genomic research partnership promises to redefine and transform cancer treatment

Personalized cancer therapies are on the horizon thanks to a new genomic cancer research partnership between the Gene Editing Institute of Christiana Care Health System's Helen F. Graham Cancer Center & Research Institute and the biotechnology company NovellusDx.

21 Jul 2017

Researchers devise strategy to target Achilles heel of nervous system cancers

Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment.

21 Jul 2017

Study identifies new mutations linked to hereditary neuroendocrine tumors

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors with a strong hereditary component. Half the genes whose alterations confer hereditary susceptibility to develop this condition code for enzymes involved in the Krebs cycle, a metabolic route involved in cellular respiration.

20 Jul 2017

Researchers uncover new clues to why BRCA1 mutations cause breast and ovarian cancer

The human body holds many mysteries, and function of the BRCA1 gene is among them. Women who inherit a faulty copy of BRCA1 have up to a 65 percent chance to develop breast cancer by age 70. They also have up to a 39 percent chance to develop ovarian cancer.

19 Jul 2017

Research shows how dietary essential fatty acids can help treat Alzheimer’s, other diseases

Understanding how dietary essential fatty acids work may lead to effective treatments for diseases and conditions such as stroke, Alzheimer's disease, age-related macular degeneration, Parkinson's disease and other retinal and neurodegenerative diseases.

18 Jul 2017

Mutation News and Research

Scientists uncover link between backup pathogen-fighting system and mutations in Crohn's patients

Study identifies key component that allows deadly bacteria to spread antibiotic resistance

New compound takes positive step toward creating drug for melanoma

Gene's position on chromosome influences mutations, study shows

African-American patients have increased gene mutations in tobacco-related tumors, study finds

Preclinical study demonstrates efficacy of gene therapy in treatment of Duchenne muscular dystrophy

New map may be first step to developing treatments for complex brain disorders

New way of producing flu vaccine could provide better protection against infection

Wistar scientists discover new therapeutic strategy for difficult-to-treat form of ovarian cancer

Study provides deeper understanding into genetic basis of neuropsychiatric disorders

Wayne State researchers receive $1.9 million NIH grant to better understand rare genetic disorders

New genomic research partnership promises to redefine and transform cancer treatment

Researchers devise strategy to target Achilles heel of nervous system cancers

Study identifies new mutations linked to hereditary neuroendocrine tumors

Researchers uncover new clues to why BRCA1 mutations cause breast and ovarian cancer

Research shows how dietary essential fatty acids can help treat Alzheimer’s, other diseases

Researchers discover gene mutations that worsen respiratory infections among children

NIH researchers show how investigational drug works against rare, fatal genetic disease

Mutations arising after conception may play vital role in autism

'Organic gene therapy' could be effective treatment approach for serious blood disorders

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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