Immune Response News and Research

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Study shows the strategies tumor cells use to evade immune defense

Scientists are increasingly trying to use the body's own immune system to fight cancer. A new study by the University of Bonn and research institutions in Australia and Switzerland now shows the strategies tumor cells use to evade this attack.

5 Aug 2020

Study demonstrates the dual effect of acetate in immune response

The concentration of acetate increases particularly sharply at the site of an infection in the body. As reported in the journal Cell Metabolism by a team of researchers from the University of Basel and colleagues, acetate supports the function of certain immune cells and thus helps to eliminate pathogens safely and efficiently.

5 Aug 2020

Study: Inhibition of TLK protein stimulates the innate immune system

Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication.

5 Aug 2020

Dire COVID-19 warning from World Health Organization

The coronavirus pandemic (COVID-19) has swept across the globe, infecting more than 18 million people. With the rapid spread of the virus, the World Health Organization (WHO) warns that there might never be a “silver bullet” to combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

5 Aug 2020

Estrogen modestly protective against COVID-19?

Almost from the beginning, scientists have been struck by the disproportionately higher numbers of men and older adults who have developed severe COVID-19 disease compared to younger individuals and women. Prior research has shown that in 37 of the 38 countries from which sex-stratified data was available, males were at a higher risk of death. Also, post-menopausal women are at increased risk of severe COVID-19. However, the biological underpinnings of this have been less visible.

4 Aug 2020

Membrane protein regulates epigenetic plasticity by mediating iron endocytosis

CNRS researchers at the Institut Curie have recently shown that cancer cells use a membrane protein that has been known for several decades to internalise iron.

3 Aug 2020

New biomarkers may identify Type 1 diabetes patients who could benefit from immunotherapy

Scientists at UCL have discovered new biomarkers, which may identify those people with Type 1 diabetes who would benefit from the immunotherapy drug Abatacept, a finding which could eventually help thousands manage the disease more effectively.

3 Aug 2020

Stabilized prefusion spike vaccine candidate induces powerful immune response

A new research paper by scientists at Janssen Vaccines & Prevention BV, in the Netherlands and published on the preprint server bioRxiv* is based on the assumption that an effective vaccine against these infections will induce neutralizing antibodies and an immune response favoring Th1 immunity.

3 Aug 2020

SARS-CoV-2 spike protein recognized by innate immune receptors in a glycan-dependent way

The spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) depends on its ability to infect new host cells following its replication and release from infected cells. This pivots on its ability to bind to cell surface receptors like the ACE2 enzyme.

3 Aug 2020

The race to a coronavirus vaccine

As the number of coronavirus disease (COVID-19) cases skyrocket to a staggering 18 million, the race to attain vaccine approval is on. More than a hundred candidate vaccines are being developed and tested to prevent infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Now, many vaccine candidates are undergoing human stage 2 and 3 trials to prove their efficacy and safety.

2 Aug 2020

New bivalent vaccine delivers robust cell-mediated and humoral immunity against SARS-CoV-2

In a groundbreaking bioRxiv study, US researchers demonstrate the capability of next-generation bivalent human adenovirus serotype 5 (hAd5) vaccine for inducing both cellular and humoral immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – using both an S protein sequence optimized for cell surface expression and a conserved nucleocapsid antigen designed to be transported to the endosomal subcellular compartment.

2 Aug 2020

Touchlight, Cancer Research UK and University of Southampton team up to develop DNA cancer vaccine

Cancer Research UK, the University of Southampton and Touchlight Genetics, a London based biotechnology company, today (Wednesday) announce a new clinical development partnership to progress a therapeutic DNA vaccine, TGL-100, into an early phase clinical trial targeting head and neck squamous cell carcinoma.

31 Jul 2020

Researchers report a liquid biopsy for COVID-19

A new study published on the preprint server medRxiv in July 2020 reports the potential of cell-free DNA as a marker of the severity of disease in COVID-19. This could help triage patients as well as provide a prognostic marker.

30 Jul 2020

From swab to sequencing - scalable method for identifying SARS-CoV-2

A research group headed by Stanford University scientists has developed a scalable, high throughput method to generate high fidelity whole genome and HLA sequencing, viral genomes, and representation of human transcriptome from single nasopharyngeal swabs of coronavirus disease (COVID19) patients. Their results are published on the medRxiv preprint server.

30 Jul 2020

Investigational vaccine and immune therapy work well together to fight breast cancer

A vaccine for HER2-positive breast cancers that is being tested in a clinical trial at Duke Cancer Institute is part of an effective, two-drug strategy for enlisting the immune system to fight tumors, according to a Duke-led study in Clinical Cancer Research, a journal of the American Association for Cancer Research.

30 Jul 2020

Clinical study evaluates potential of oral cancer drug to reduce respiratory symptoms of COVID-19

Researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and The Ohio State University Wexner Medical Center are conducting a new clinical trial to determine if an oral cancer drug called ibrutinib can also help patients with cancer or other immunocompromised conditions recover from COVID-19.

29 Jul 2020

Study explores if prior exposure to common cold viruses may affect SARS-CoV-2 severity

A study led by Charité - Universitätsmedizin Berlin and the Max Planck Institute for Molecular Genetics (MPIMG) shows that some healthy individuals possess immune cells capable of recognizing the novel coronavirus, SARS-CoV-2.

29 Jul 2020

Early-in-life antibiotic exposure increases susceptibility to inflammatory bowel disease

Even short, single antibiotic courses given to young animals can predispose them to inflammatory bowel disease (IBD) when they are older, according to Rutgers researchers.

29 Jul 2020

Researchers identify potential anti-viral strategy for SARS-CoV-2 virus

In the case of an infection, the SARS-CoV-2 virus must overcome various defense mechanisms of the human body, including its non-specific or innate immune defense. During this process, infected body cells release messenger substances known as type 1 interferons. These attract natural killer cells, which kill the infected cells.

29 Jul 2020

COVID-19 test kits offered by Carolina Liquid Chemistries granted FDA emergency use authorization

Carolina Liquid Chemistries, Corp., an innovative leader in clinical diagnostics and drug screening, is now offering test kits for COVID-19 that have been granted Emergency Use Authorization by the US Food and Drug Administration, pursuant to Section 564 of the Federal Food, Drug, and Cosmetic Act.

From Carolina Liquid Chemistries Corp. 29 Jul 2020

Immune Response News and Research

Study shows the strategies tumor cells use to evade immune defense

Study demonstrates the dual effect of acetate in immune response

Study: Inhibition of TLK protein stimulates the innate immune system

Dire COVID-19 warning from World Health Organization

Estrogen modestly protective against COVID-19?

Membrane protein regulates epigenetic plasticity by mediating iron endocytosis

New biomarkers may identify Type 1 diabetes patients who could benefit from immunotherapy

Stabilized prefusion spike vaccine candidate induces powerful immune response

SARS-CoV-2 spike protein recognized by innate immune receptors in a glycan-dependent way

The race to a coronavirus vaccine

New bivalent vaccine delivers robust cell-mediated and humoral immunity against SARS-CoV-2

Touchlight, Cancer Research UK and University of Southampton team up to develop DNA cancer vaccine

Researchers report a liquid biopsy for COVID-19

From swab to sequencing - scalable method for identifying SARS-CoV-2

Investigational vaccine and immune therapy work well together to fight breast cancer

Clinical study evaluates potential of oral cancer drug to reduce respiratory symptoms of COVID-19

Study explores if prior exposure to common cold viruses may affect SARS-CoV-2 severity

Early-in-life antibiotic exposure increases susceptibility to inflammatory bowel disease

Researchers identify potential anti-viral strategy for SARS-CoV-2 virus

COVID-19 test kits offered by Carolina Liquid Chemistries granted FDA emergency use authorization

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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