Cell Death News and Research

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New understanding of sphingosine kinases called SphK1 and SphK2

Virginia Commonwealth University Massey Cancer Center researchers have found that two enzymes that catalyze the same reaction and produce the same product have opposite effects on cell growth and death.

7 Nov 2005

Substance found in evening primrose oil inhibits breast cancer gene

Gamma-linolenic acid (GLA), a substance in evening primrose oil and several other plant oils used in herbal medicine, inhibits action of Her-2/neu, a cancer gene that is responsible for almost 30 percent of all breast cancers, Northwestern University researchers report.

3 Nov 2005

Protein called CHIP helps untangle protein misfolding in brain disease

Keeping the body and mind healthy depends on keeping cells healthy and functioning. This means that cells need a very robust quality-control system to repair or remove damaged or misshapen proteins. Protein handling is especially important in neurons because damage or death of brain cells causes neurological disease.

1 Nov 2005

Northwestern University move closer to new therapies for neurodegenerative disease

French neurologist Jean-Martin Charcot first described amyotrophic lateral sclerosis (ALS) in 1869, but, nearly 140 years later, little is known about the cause of the devastating neurodegenerative disease, and there is no cure.

27 Oct 2005

Lack of gene expression associated with ovarian cancer

The expression of two specific genes is almost completely downregulated in ovarian cancer tumours. An extensive analysis of gene expression in ovarian cancer tumour cells has revealed this important finding, which should be an aid to early diagnosis.

24 Oct 2005

Discovery could lead to tests for the clinic or battlefield to diagnose ailments with just a few drops of blood

A way to detect fragments of broken brain cells that leak into the bloodstream may help doctors more quickly and precisely treat people with severe head injuries or brain diseases, say researchers at the University of Florida's McKnight Brain Institute.

17 Oct 2005

Study identifies molecular switch that integrates cell survival signals from multiple intracellular signaling pathways

The finding has substantial clinical significance, as mutations in these cell survival-signaling pathways are associated with many human cancers, and a better understanding of how these pathways converge to regulate the delicate balance between cell proliferation and cell death may lead to development of more effective cancer therapies.

17 Oct 2005

WWOX gene finding could lead to a new strategy for treating lung cancer

The research focused on a gene known as WWOX, which is lost or silenced in a large majority of lung cancers, and in cancers of the breast, ovary, prostate, bladder, esophagus and pancreas. The work was led by scientists at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

17 Oct 2005

Curry spice appears to shut down a protein active in the spread of breast cancer

Curcumin, the main ingredient of turmeric and the compound that gives curry its mustard-yellow color, inhibits metastasis to the lungs of mice with breast cancer, report researchers at The University of Texas M. D. Anderson Cancer Center

16 Oct 2005

E-cadherin, that cellular touch so important in cancer

E-cadherin is a molecule involved in adhesion between epithelial cells that also seems to have a protective role in cancer, since its loss is associated with tumour progression and metastases formation in a series of different cancers.

16 Oct 2005

Fijiian seaweed shows potential to kill cancer cells, bacteria and the HIV virus

Researchers have discovered 10 new molecular structures with pharmaceutical potential in a species of red seaweed that lives in the shallow coral reef along the coastline of Fiji in the south Pacific Ocean.

12 Oct 2005

Researchers find CCL5 protein produced in the course of respiratory viral infections can serve to protect macrophages from an untimely death

Enlisted to help fight viral infections, immune cells called macrophages consume virus-infected cells to stop the spread of the disease in the body.

9 Oct 2005

Discovery provides an understanding of the mechanisms of oocyte death and a way to identify potential clinical treatments for infertility

An immature egg's internal nutrient supply is critical to its survival, an insight that offers a new route to understanding and treating infertility due to egg death, according to Duke University Medical Center researchers.

9 Oct 2005

Researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model

The first close-up look at a pro-inflammatory signaling molecule involved in immune response in mammals suggests that researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model, scientists say.

4 Oct 2005

Study shows that high-fat diets correlate to a chronic inflammatory state in the liver,

Mice that were fed diets high in fat and sugar developed immune system abnormalities in their livers, including reduced numbers of natural killer T (NKT) cells. These diet-related changes may contribute to obesity-related liver disease, according to a new study.

3 Oct 2005

Research may help create drugs to target the molecule-binding pathway, beneficial for treating arthritis and reducing inflammation

3 Oct 2005

Computer program helps explain how the same proteins can play different roles in a wide range of cellular processes

University of California, San Diego biochemists have developed a computer program that helps explain a long-standing mystery: how the same proteins can play different roles in a wide range of cellular processes, including those leading to immune responses and cancer.

27 Sep 2005

Possible molecular origin of at least nine human diseases of nervous system degeneration

These neurodegenerative diseases, including Huntington's disease, share an abnormal deposit of proteins inside nerve cells. This deposition of protein results from a kind of genetic stutter within the cell's nucleus asking for multiple copies of the amino acid glutamine, a building block of protein structure.

26 Sep 2005

Researchers discover way to dramatically boost the output of immune system cells from the thymus

Mayo Clinic researchers have discovered a way to dramatically boost the output of immune system cells from the thymus, which may lead to improved cancer vaccines, as well as to ways to otherwise strengthen immune responses.

26 Sep 2005

Suppression of FOXO1a gene might kill resistant alveolar rhabdomyosarcoma (ARMS) tumors

FOXO1a caused death of tumor cells in laboratory study by triggering expression of caspase-3, which blocks cell division and causes cells to undergo apoptosis, according to St. Jude.

20 Sep 2005

Cell Death News and Research

New understanding of sphingosine kinases called SphK1 and SphK2

Substance found in evening primrose oil inhibits breast cancer gene

Protein called CHIP helps untangle protein misfolding in brain disease

Northwestern University move closer to new therapies for neurodegenerative disease

Lack of gene expression associated with ovarian cancer

Discovery could lead to tests for the clinic or battlefield to diagnose ailments with just a few drops of blood

Study identifies molecular switch that integrates cell survival signals from multiple intracellular signaling pathways

WWOX gene finding could lead to a new strategy for treating lung cancer

Curry spice appears to shut down a protein active in the spread of breast cancer

E-cadherin, that cellular touch so important in cancer

Fijiian seaweed shows potential to kill cancer cells, bacteria and the HIV virus

Researchers find CCL5 protein produced in the course of respiratory viral infections can serve to protect macrophages from an untimely death

Discovery provides an understanding of the mechanisms of oocyte death and a way to identify potential clinical treatments for infertility

Researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model

Study shows that high-fat diets correlate to a chronic inflammatory state in the liver,

Research may help create drugs to target the molecule-binding pathway, beneficial for treating arthritis and reducing inflammation

Computer program helps explain how the same proteins can play different roles in a wide range of cellular processes

Possible molecular origin of at least nine human diseases of nervous system degeneration

Researchers discover way to dramatically boost the output of immune system cells from the thymus

Suppression of FOXO1a gene might kill resistant alveolar rhabdomyosarcoma (ARMS) tumors

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