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Insights into drug absorption and predictive modeling with Professor Kiyohiko Sugano

Learn how drug absorption and predictive modeling drive advancements in pharmaceuticals and precision medicine.

From Pion Inc 18 Mar 2025

NKD2 protein discovery opens up new possibilities in the fight against bone loss

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts.

17 Mar 2025

Novel cyclic peptide antagonist can be a promising therapeutic approach for MASH

The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism.

14 Mar 2025

Breakthrough peptide inhibitor effective against multiple SARS-CoV-2 variants

SARS-CoV-2, the virus responsible for COVID-19, infects cells by binding its spike protein to angiotensin-converting enzyme 2 (ACE2) receptors.

14 Mar 2025

Engineered nano-aircraft carrier enhances tumor targeting and immune response

The researchers designed an efficient approach for fabricating engineered Pts-based nano-aircraft carriers with graded drug delivery and ECM degradation for precise cancer chemoimmunotherapy.

14 Mar 2025

Study uncovers new insights into pain pathways linked with temporomandibular joint disorders

A groundbreaking study has uncovered new insights into the pain pathways associated with temporomandibular joint (TMJ) disorders.

13 Mar 2025

CRISPR technologies paving the way for advances in regenerative medicine

A recent review published in the journal Engineering delves into the significant advancements and potential of CRISPR technologies in the field of regenerative medicine.

13 Mar 2025

Is fluoride safe for your gut? New study investigates

Systematic review finds that while low-dose fluoride has little effect on gut microbiota, high doses disrupt microbial diversity and balance, especially in animal studies. The effects vary by species, fluoride form, and exposure level, raising concerns about high-dose fluoride impacts on gut health.

11 Mar 2025

New automated system revolutionizes drug evaluation in zebrafish

Preclinical drug evaluation, especially for cardiotoxicity, is a critical stage in the drug development process.

11 Mar 2025

Can microbiome discoveries finally become treatments? Scientists show the way

Researchers propose a novel iterative strategy combining big data and experimental models to move microbiome research from theory to clinical applications. The study highlights the need to bridge the gap between correlation and causation to develop effective microbiome-based therapies.

9 Mar 2025

Long-term NSAID use may lower dementia risk

Long-term NSAID use reduces dementia risk, particularly in those without the APOE-ε4 gene, highlighting the importance of sustained anti-inflammatory treatment over dosage levels.

9 Mar 2025

These simple diet tweaks could slash microplastics in your body

Researchers identify dietary and lifestyle-based strategies that may reduce human exposure to microplastics and nanoplastics.

9 Mar 2025

Exosome-mediated siRNA delivery targets antibiotic resistance in bacteria

Multidrug-resistant bacteria pose a major threat to human health. Manipulation of bacterial genes at the transcriptional level is a potential strategy to fight antibiotic-resistant bacterial infections by silencing their resistance genes.

7 Mar 2025

UC San Diego researchers discover new way to predict breast cancer spread

By assessing how "sticky" tumor cells are, researchers at the University of California San Diego have found a potential way to predict whether a patient's early-stage breast cancer is likely to spread.

5 Mar 2025

Extreme heat may speed up aging

Researchers determine the role of ambient outdoor heat in epigenetic aging.

5 Mar 2025

Cheese isn't just food—it’s a microbiome booster, study confirms

Scientists reveal that cheese-derived bacteria, particularly less abundant strains, can shape gut microbiota and enhance metabolic functions, underscoring the impact of fermented foods on gut health.

3 Mar 2025

Novel adipose tissue biofabrication approach paves the way for enhanced skin regeneration

The adipose tissue, which serves as an endocrine organ, releases various molecules that regulate the repair of other damaged tissues, including the skin.

3 Mar 2025