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Nuvo: FDA accepts to review New Drug Application for PENNSAID 2%

Nuvo Research Inc., a specialty pharmaceutical company dedicated to building a portfolio of products for the topical treatment of pain and the development of its immune modulating drug candidate WF10 today announced that its U.S. licensee for PENNSAID (diclofenac sodium topical solution) 1.5% w/w and PENNSAID 2% (diclofenac sodium topical solution) 2% w/w, Mallinckrodt has advised that the U.S. Food and Drug Administration has accepted for filing and review the New Drug Application for PENNSAID 2% submitted by Mallinckrodt on August 7, 2013.

22 Aug 2013

Takeda announces publication of data from two vedolizumab Phase 3 studies for ulcerative colitis and Crohn’s disease

Takeda Pharmaceutical Company Limited today announced that results from two Phase 3 studies evaluating vedolizumab, an investigational humanized monoclonal antibody, for the treatment of adults with moderately to severely active ulcerative colitis and Crohn’s disease, were published in the August 22, 2013 issue of the New England Journal of Medicine.

22 Aug 2013

Assumption that uterine blood redistributed into maternal circulation after delivery challenged

In an examination comparing the effects of two drugs on blood pressure, pulse, heart rate and cardiac output in women having elective delivery by cesarean section, an old assumption that uterine blood is redistributed into the maternal circulation after delivery was challenged, according to a study in the September issue of Anesthesiology.

22 Aug 2013

Antipsychotic drug not effective in treating delirium in critically ill patients

Haloperidol, an antipsychotic drug used in many hospitals to treat delirium in critically ill patients, is no more effective than placebo in reducing the number of days that critically ill patients spend either delirious or in a coma, according to new research published in The Lancet Respiratory Medicine.

22 Aug 2013

Pazopanib drug shows improved quality of life and safety in metastatic kidney cancer patients

Two oral targeted drugs approved for metastatic kidney cancer worked equally well, but one proved superior in tolerability, according to results of a large international clinical trial led by researchers at Dana-Farber Cancer Institute.

22 Aug 2013

New antibody drug shows positive results for treating Crohn's disease, ulcerative colitis

Vedolizumab, a new intravenous antibody medication, has shown positive results for treating both Crohn's disease and ulcerative colitis, according to researchers at the University of California San Diego, School of Medicine. The findings, published in two papers, will appear in the August 22 issue of the New England Journal of Medicine (NEJM).

22 Aug 2013

Alarm therapy or drug therapy may solve bedwetting problems in children

Bedwetting affects up to 20 percent of five year olds—the age when most children have learned bladder control—and can result in an array of stressful and embarrassing social, emotional and psychological problems.

21 Aug 2013

Twice-daily KALYDECO improves lung function in people with cystic fibrosis

Vertex Pharmaceuticals (Australia) Pty Ltd., announces the presentation of data from KALYDECO (ivacaftor) studies at the 10th Australasian Cystic Fibrosis Conference in Auckland, New Zealand, August 17 – 20, 2013, which further demonstrate the benefits of the medicine in people with cystic fibrosis ages 6 and older who have at least one copy of the G551D mutation in the cystic fibrosis transmembrane conductance regulator gene.

21 Aug 2013

Glucagon loses its ability to help obese people, but continues to suppress hunger pangs

Glucagon, a hormone involved in regulating appetite, loses its ability to help obese people feel full after a meal, but it continues to suppress hunger pangs in people with type 1 diabetes, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

21 Aug 2013

Researchers outline recommendations to lower costs and lead to better care for patients

Medical organizations are participating in a campaign to help clinicians and patients avoid wasteful and sometimes harmful medical interventions. Recently, experts in pediatric and adult health from diverse geographic locations of the United States and from a mix of academic and non- academic settings shared their experiences, consulted their colleagues, and analyzed numerous studies in the medical literature to determine the top recommendations for improving healthcare value.

20 Aug 2013

Patients with heart failure who see physician after leaving hospital are more likely to survive

Patients with heart failure who see a physician in the first month after leaving hospital are more likely to survive than those who do not see a doctor, reports a new study in CMAJ (Canadian Medical Association Journal). The effect is slightly more pronounced in patients who see their regular physician rather than an unfamiliar physician.

20 Aug 2013

Phase III trial evaluates impact of Wisconsin Ginseng on fatigue levels of cancer patients

Millions of cancer patients find themselves exhausted completing the most mundane of tasks, and extra sleep doesn't seem to help. Today, they find hope in a supplement that medical researchers have shown to be effective in boosting their energy levels: Wisconsin Ginseng.

20 Aug 2013

NCI-PCPT explores survival of men on finasteride drug

In the NCI-sponsored Prostate Cancer Prevention Trial (PCPT), initial findings from a decade ago showed that the drug finasteride significantly reduced the risk of prostate cancer, but among those who did develop prostate cancer, paradoxically, the drug was associated with an increased risk of high-grade disease.

20 Aug 2013

Calcium and vitamin D supplements have no effect on joint symptoms in postmenopausal women

A team of investigators systematically analyzed the effect of calcium and vitamin D supplementation on joint symptoms in a rigorous and controlled study of postmenopausal women. They found that supplementation did not reduce the severity of joint symptoms reported by the participants.

17 Aug 2013

Study: Type 2 diabetic patients treated with DPP-4 linagliptin experience reductions in blood glucose levels

Data published in The Lancet showed that elderly people with Type 2 Diabetes (T2D) treated for 24 weeks with the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin, marketed by Boehringer Ingelheim and Eli Lilly and Company, experienced significant reductions in blood glucose levels (HbA1c) compared with those receiving placebo.

17 Aug 2013

Individuals with ASD display altered brain activations when processing facial images

Difficulty in registering and responding to the facial expressions of other people is a hallmark of autism spectrum disorder (ASD). Relatedly, functional imaging studies have shown that individuals with ASD display altered brain activations when processing facial images.

16 Aug 2013

Probiotic does not prevent clinical relapse in patients with Crohn's disease

Despite previous data showing beneficial effects, the probiotic Saccharomuces boulardii (S. boulardii) does not prevent clinical relapse in patients with Crohn's disease, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

16 Aug 2013

Joint symptoms in postmenopausal women not reduced by calcium and vitamin D supplements

A team of investigators systematically analyzed the effect of calcium and vitamin D supplementation on joint symptoms in a rigorous and controlled study of postmenopausal women.

16 Aug 2013

Study identifies individuals who benefit from vitamin D supplementation

Studying the expression of genes that are dependent on vitamin D makes it possible to identify individuals who will benefit from vitamin D supplementation, shows a University of Eastern Finland study published recently in PLoS One.

13 Aug 2013

Vitamin D supplementation does not improve blood pressure in hypertension patients

Vitamin D supplementation does not appear to improve blood pressure or markers of vascular health in older patients with isolated systolic hypertension (a common type of high blood pressure), according to a study by Miles D. Witham, Ph.D., of the University of Dundee, Scotland, United Kingdom, and colleagues.

13 Aug 2013

Placebo News and Research

Nuvo: FDA accepts to review New Drug Application for PENNSAID 2%

Takeda announces publication of data from two vedolizumab Phase 3 studies for ulcerative colitis and Crohn’s disease

Assumption that uterine blood redistributed into maternal circulation after delivery challenged

Antipsychotic drug not effective in treating delirium in critically ill patients

Pazopanib drug shows improved quality of life and safety in metastatic kidney cancer patients

New antibody drug shows positive results for treating Crohn's disease, ulcerative colitis

Alarm therapy or drug therapy may solve bedwetting problems in children

Twice-daily KALYDECO improves lung function in people with cystic fibrosis

Glucagon loses its ability to help obese people, but continues to suppress hunger pangs

Researchers outline recommendations to lower costs and lead to better care for patients

Patients with heart failure who see physician after leaving hospital are more likely to survive

Phase III trial evaluates impact of Wisconsin Ginseng on fatigue levels of cancer patients

NCI-PCPT explores survival of men on finasteride drug

Calcium and vitamin D supplements have no effect on joint symptoms in postmenopausal women

Study: Type 2 diabetic patients treated with DPP-4 linagliptin experience reductions in blood glucose levels

Individuals with ASD display altered brain activations when processing facial images

Probiotic does not prevent clinical relapse in patients with Crohn's disease

Joint symptoms in postmenopausal women not reduced by calcium and vitamin D supplements

Study identifies individuals who benefit from vitamin D supplementation

Vitamin D supplementation does not improve blood pressure in hypertension patients

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