Efficacy News and Research

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Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

Researchers evaluated the efficacy of PHELA, a traditional African drug, against SARS-CoV-2 in vitro.

21 Jun 2022

An estimate of Omicron's fitness advantage

Researchers quantify the transmission advantage of the SARS-CoV-2 Omicron variant across forty countries.

21 Jun 2022

Real-world study shows Paxlovid associated with lower hospitalization rates

In a recent study posted to the medRxiv* pre-print server, researchers investigated the effectiveness of nirmatrelvir plus ritonavir in preventing hospitalizations among individuals aged 50 or older and vaccinated for coronavirus disease 2019 (COVID-19).

20 Jun 2022

New combination of drugs effective against T-cell acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the most common cancer affecting children. The T-ALL form of leukemia that emerges from early T lineage cells has a poorer prognosis than B-lineage ALL. The prognosis for relapsed T-ALL is very poor and new therapies are sorely needed.

20 Jun 2022

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

In a recent study posted to the bioRxiv* preprint server, researchers at Weill Cornell Medical College assessed the cleavability of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and related coronaviruses by several proteases of the host.

19 Jun 2022

Study points to a new direction for the development of NAMPT-targeted cancer therapies

In this new article publication from Acta Pharmaceutica Sinica B, authors Ying Wu, Congying Pu, Yixian Fu, Guoqiang Dong, Min Huang and Chunquan Sheng from Second Military Medical University, Shanghai, China and University of Chinese Academy of Sciences, Shanghai, China discuss how NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion.

18 Jun 2022

Math model predicts several useful new drug combinations that may help treat heart attacks

Researchers used mice to develop a mathematical model of a myocardial infarction, popularly known as a heart attack.

17 Jun 2022

Effectiveness of previous COVID-19 and vaccination against SARS-CoV-2 Omicron infection

Researchers studied the effects of prior immunity on symptomatic infection by SARS-CoV-2 Omicron.

17 Jun 2022

Fecal microbiota transplant shows durable effect in treating irritable bowel syndrome

A new study discusses the efficacy of fecal transplant in patients with IBS three years after the procedure was performed.

16 Jun 2022

Study confirms heightened protection from Omicron-associated hospitalizations by COVID boosters

In a recent article posted to the medRxiv* preprint server, scientists assessed the efficacy of the primary and boosted regimens of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations in preventing SARS-CoV-2 Omicron-linked hospitalizations in the United States (US).

16 Jun 2022

Obesity causes COVID vaccines to lose their efficacy more rapidly

In a recent study posted to the medRxiv* pre-print server, researchers examined a clinical cohort of severely obese people vaccinated with coronavirus disease 2019 (COVID-19) vaccines to determine the relationship between an individual's body mass index (BMI) and COVID-19-related hospitalization and mortality.

16 Jun 2022

Chemical synthesis, properties, and molecular modeling studies of spiro-indole compounds

In a recent study under review at the Scientific Reports journal and currently posted to the Research Square* preprint server, researchers synthesized and evaluated the antitumoral (against several cancer cell lines) and antiviral [against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] properties of 3-spiro-indolin-2-ones.

15 Jun 2022

Fc-effector functions for selecting COVID-19 convalescent plasma

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated that coronavirus disease 2019 (COVID-19) convalescent plasmas (CCPs) with low neutralizing and high fragment crystallizable (Fc)-effector activity result in effective prophylaxis.

15 Jun 2022

Flexible model of care can be effective in treating opioid use disorder

Did you know that more than 26,500 Canadians died from opioid intoxication between January 2016 and September 2021? Or that more than 350,000 people who used drugs containing opioids to relieve their pain did so problematically?

15 Jun 2022

New studies examine the causes and effects of COVID-19-related food insecurity

The COVID-19 pandemic affected people at all stages of life from seniors to newborns. New studies presented at NUTRITION 2022 LIVE ONLINE examine the causes and effects of COVID-19-related food insecurity, how the pandemic affected breastfeeding practices and more.

14 Jun 2022

SARS-CoV-2 Omicron breakthrough infection less immunogenic than Delta

Scientists investigate the sequence and dynamics of recalled immune memory in convalescent individuals who have been vaccinated against COVID-19.

14 Jun 2022

Spirea raises £2.4M ($3M) to develop antibody drug conjugates in cancer

Funding will enable the development of Spirea’s pipeline of antibody drug conjugate therapeutics for the treatment of solid tumours.

From Spirea 14 Jun 2022

The virucidal effects of tea tree oil against FCoVII and HCoV-OC43

Researchers assessed the probable efficacy of tea tree oil (TTO) as a natural disinfectant against SARS-CoV-2 using the human coronavirus OC43 (HCoV-OC43) and feline coronavirus (FCoVII) as surrogate models.

14 Jun 2022

Evidence-based study shows how hypnotherapy provides positive outcomes for IBS patients

It is common that Hong Kong people might have experiences of disordered defecation with unknown reason, such as diarrhea and constipation. It is also easy to observe that abdominal discomforts often come along with stress. Emotion disturbance and stress might affect our intestinal functions.

14 Jun 2022

Genomic analysis of the 2022 monkeypox outbreak

In a recent study posted to the bioRxiv* pre-print server, researchers analyzed two genomic sequences of the Monkeypox virus from Belgium and Portugal termed ITM001 and PT0001, respectively, to show that the May 2022 Monkeypox outbreak most likely originated from the West African clade of the virus.

14 Jun 2022

Efficacy News and Research

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

An estimate of Omicron's fitness advantage

Real-world study shows Paxlovid associated with lower hospitalization rates

New combination of drugs effective against T-cell acute lymphoblastic leukemia

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

Study points to a new direction for the development of NAMPT-targeted cancer therapies

Math model predicts several useful new drug combinations that may help treat heart attacks

Effectiveness of previous COVID-19 and vaccination against SARS-CoV-2 Omicron infection

Fecal microbiota transplant shows durable effect in treating irritable bowel syndrome

Study confirms heightened protection from Omicron-associated hospitalizations by COVID boosters

Obesity causes COVID vaccines to lose their efficacy more rapidly

Chemical synthesis, properties, and molecular modeling studies of spiro-indole compounds

Fc-effector functions for selecting COVID-19 convalescent plasma

Flexible model of care can be effective in treating opioid use disorder

New studies examine the causes and effects of COVID-19-related food insecurity

SARS-CoV-2 Omicron breakthrough infection less immunogenic than Delta

Spirea raises £2.4M ($3M) to develop antibody drug conjugates in cancer

The virucidal effects of tea tree oil against FCoVII and HCoV-OC43

Evidence-based study shows how hypnotherapy provides positive outcomes for IBS patients

Genomic analysis of the 2022 monkeypox outbreak

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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