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Rapamycin drug reduces obesity, preserves lean body mass in older rats

Aging can cause many changes to the body, including obesity and a loss of lean mass. Now, a group of University of Florida Health researchers has discovered that an existing drug reduces body fat and appetite in older rats, which has intriguing implications for aging humans.

17 Jun 2015

Researchers create cell lines to study gene expression in precursor brown fat and white fat cells

Since the 2009 discovery that energy-burning brown fat can be active in adults, research has raced ahead to understand this tissue and exploit it to treat the epidemic of obesity. Active brown fat also may assist in directly easing the burden of diabetes and related metabolic diseases by lowering the levels of glucose and fatty acids in the bloodstream. But progress in studying human brown fat often has been slowed by difficulties in obtaining and studying samples of the human cells that develop into brown fat.

17 Jun 2015

Understanding crosstalk between cells in the pancreas can help treat diabetes

Sometimes, listening in on a conversation can tell you a lot. For Mark Huising, an assistant professor in the Department of Neurobiology, Physiology and Behavior at the UC Davis College of Biological Sciences, that crosstalk is between the cells that control your body's response to sugar, and understanding the conversation can help us understand, and perhaps ultimately treat, diabetes.

16 Jun 2015

Scientists report that mouse with weak bones appears to have strong metabolism

One mouse with weak bones appears to have a strong metabolism, even on a high-fat diet, scientists report. While weaker bones are clearly not a good thing, scientists suspect that, somewhere in the conversation between the genetically engineered mouse's skeleton and the rest of its body, there may be an answer that helps obese individuals avoid some of the worst ravages of this health epidemic.

16 Jun 2015

Scientists find way to accelerate wound healing in diabetic mice

One of the body's own tools for preventing wound infections may actually interfere with wound healing, according to new research from Boston Children's Hospital. In a study published online in Nature Medicine, scientists from the hospital's Program in Cellular and Molecular Medicine found they could speed up wound healing in diabetic mice by keeping immune cells called neutrophils from producing bacteria-trapping neutrophil extracellular traps (NETs).

15 Jun 2015

New therapy for osteoporosis may be in the pipeline

Researchers from The Scripps Research Institute (TSRI), Florida, have reported a novel therapeutic approach that could promote the formation of new bone cells in people suffering from bone loss.

12 Jun 2015

Paediatric outpatient study compares effectiveness of three alternative treatments for type 1 diabetes

A Montréal research team, co-supervised by Dr. Rémi Rabasa-Lhoret from the IRCM and Dr. Laurent Legault from the Montreal Children's Hospital, undertook the first paediatric outpatient study to compare three alternative treatments for type 1 diabetes.

11 Jun 2015

Novel combination of non-toxic dietary and hyperbaric oxygen therapies doubles survival time in cancer model

A team of researchers from the Hyperbaric Biomedical Research Laboratory at the University of South Florida (USF) doubled survival time in an aggressive metastatic cancer model using a novel combination of non-toxic dietary and hyperbaric oxygen therapies.

11 Jun 2015

Study highlights the need to reduce non-communicable diseases

There is a great need to slow down the increasing number of people who die prematurely because of non-communicable diseases (NCDs) such as cardiovascular disease, diabetes and cancer.

10 Jun 2015

Combining lifestyle modification with metformin could help women manage polycystic ovary syndrome

A systematic review publishing today in the journal Human Reproduction Update has found that women who suffer from polycystic ovary syndrome (PCOS) could manage some of the symptoms by combining a change in lifestyle with taking the drug metformin.

10 Jun 2015

Researchers investigate how ingested nanoparticles may influence metabolic processes

Researchers at Binghamton University believe understanding nano particles' ability to influence our metabolic processing may be integral to mediating metabolic disorders and obesity, both of which are on the rise and have been linked to processed foods.

10 Jun 2015

UT Southwestern researchers reveal how the body controls glucose transport

UT Southwestern Medical Center scientists have gleaned a key cellular mechanism of how the body adjusts glucose levels, an important process that when abnormal can promote diabetes, cancer, and rare genetic diseases.

10 Jun 2015

Phase II clinical trial of Linsitinib launched in patients with advanced Ewing sarcoma

EUROSARC, European Clinical trials in Rare Sarcomas within an integrated translational trial network, has launched a phase II trial of Linsitinib for patients with relapsed and/or refractory Ewing Sarcoma. The trial, EORTC 1225 / OCTO 038, aims to establish pharmacodynamic responses in Ewing sarcoma tumors to Linsitinib using functional imaging and biopsies, and toxicity and clinical outcomes.

9 Jun 2015

Researchers pinpoint gene that may solve the root cause of diabetes

Professor Jeffery Tessem has pinpointed a gene that may help solve a riddle at the root of diabetes, the high-blood-sugar disease affecting 400 million people worldwide.

9 Jun 2015

Glucose-control drug sitagliptin does not raise risk of cardiovascular events

A clinical trial of the glucose-control drug sitagliptin among patients with type 2 diabetes and established cardiovascular disease has found it did not raise the risk of major adverse cardiovascular events.

9 Jun 2015

Sanofi announces results from Phase IIIb ELIXA study of Lyxumia in adults with diabetes and high CV risk

Sanofi announced today the presentation of full results of the Phase IIIb ELIXA study, which was designed to assess the cardiovascular (CV) safety of Lyxumia (lixisenatide) in adults with type 2 diabetes and high CV risk.

8 Jun 2015

Results from Intarcia's two phase 3 clinical trials of ITCA 650 to be presented at ADA's Scientific Session

Intarcia Therapeutics, Inc. today announced the presentation of results from its first two phase 3 clinical trials (FREEDOM-1 and FREEDOM-1 HBL) of its late-stage investigational candidate ITCA 650 (exenatide delivered continuously via a small matchstick-size subcutaneous osmotic mini-pump just once or twice yearly) at the 75th Scientific Sessions of the American Diabetes Association.

8 Jun 2015

GBD analysis shows over 95% of global population has health problems

Just one in 20 people worldwide (4·3%) had no health problems in 2013, with a third of the world's population (2·3 billion individuals) experiencing more than five ailments, according to a major new analysis from the Global Burden of Disease Study (GBD) 2013, published in The Lancet.

8 Jun 2015

Once-weekly Trulicity 0.75 mg shows promising results in Japanese patients with type 2 diabetes

Results from a new study of Japanese patients with type 2 diabetes showed once-weekly Trulicity 0.75 mg provided greater hemoglobin A1c (A1C) reduction compared to once-daily Victoza 0.9 mg after 52 weeks of treatment. Eli Lilly and Company will present these data at the 75th American Diabetes Association Scientific Sessions in Boston.

7 Jun 2015

Exercise during pregnancy prevents diabetes risk, reduces excessive weight gain

Women who exercise during pregnancy are less likely to have gestational diabetes, and the exercise also helps to reduce maternal weight gain, finds a study published on 3 June 2015 in BJOG: an International Journal of Obstetrics and Gynaecology.

5 Jun 2015

Glucose News and Research

Rapamycin drug reduces obesity, preserves lean body mass in older rats

Researchers create cell lines to study gene expression in precursor brown fat and white fat cells

Understanding crosstalk between cells in the pancreas can help treat diabetes

Scientists report that mouse with weak bones appears to have strong metabolism

Scientists find way to accelerate wound healing in diabetic mice

New therapy for osteoporosis may be in the pipeline

Paediatric outpatient study compares effectiveness of three alternative treatments for type 1 diabetes

Novel combination of non-toxic dietary and hyperbaric oxygen therapies doubles survival time in cancer model

Study highlights the need to reduce non-communicable diseases

Combining lifestyle modification with metformin could help women manage polycystic ovary syndrome

Researchers investigate how ingested nanoparticles may influence metabolic processes

UT Southwestern researchers reveal how the body controls glucose transport

Phase II clinical trial of Linsitinib launched in patients with advanced Ewing sarcoma

Researchers pinpoint gene that may solve the root cause of diabetes

Glucose-control drug sitagliptin does not raise risk of cardiovascular events

Sanofi announces results from Phase IIIb ELIXA study of Lyxumia in adults with diabetes and high CV risk

Results from Intarcia's two phase 3 clinical trials of ITCA 650 to be presented at ADA's Scientific Session

GBD analysis shows over 95% of global population has health problems

Once-weekly Trulicity 0.75 mg shows promising results in Japanese patients with type 2 diabetes

Exercise during pregnancy prevents diabetes risk, reduces excessive weight gain

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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