Immune System News and Research

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Defect in the interferon system associated with more severe COVID-19

A component of the human interferon system that activates SARS-CoV-2 cellular defenses appears to be defective in a proportion of humans, new research reports. COVID-19 outcomes were more severe in hospitalized patients who exhibited this immune system deficit, the study shows.

29 Sep 2021

Two proteins joined together using a free-standing, rigid link

Researchers at the Paul Scherrer Institute PSI are the first to have joined two proteins together by means of a free-standing, rigid link. The structural element holds the two protein molecules together at a defined distance and angle, much the way a barbell handle connects two weights.

29 Sep 2021

BostonGene and MD Anderson collaborate to advance the development of multiplatform biomarker signatures

The University of Texas MD Anderson Cancer Center and BostonGene Corporation today announced a strategic alliance to advance the development and clinical integration of multiplatform biomarker signatures.

28 Sep 2021

Primary sclerosing cholangitis: Therapy with synthetic bile acid acts directly on the immune system

Primary Sclerosing Cholangitis (PSC) is a rare, chronic inflammatory disease of the bile ducts and is difficult to treat. Studies conducted by the Division of Gastroenterology and Hepatology at MedUni Wien under the guidance of Michael Trauner (Department of Internal Medicine III) were able to show positive effects from the administration of synthetically produced bile acids and bile acid receptor agonists.

28 Sep 2021

Classic antidepressants show potential to enhance modern cancer treatments

Classic antidepressants could help improve modern cancer treatments. They slowed the growth of pancreatic and colon cancers in mice, and when combined with immunotherapy, they even stopped the cancer growth long-term.

28 Sep 2021

Researchers identify key molecules that may help combat inflammatory diseases

For the first time, researchers have identified key molecules within the immune system that may help fight the inflammation that drives chronic diseases including cancers, sepsis and brain disease.

27 Sep 2021

mRNA COVID vaccines prove effective in the elderly

Coronavirus disease 2019 (COVID-19) proved extremely difficult to control once it entered a country – while there were a few success stories such as New Zealand, most countries ended up resorting to lengthy and economically painful lockdowns, among other restriction measures.

27 Sep 2021

Penn scientists win 2021 Lasker Award for the discovery of therapeutic mRNA technology

As mRNA-based SARS-CoV-2 vaccines are deployed to protect hundreds of millions of people across the world and point the way to end the deadly global COVID-19 pandemic, the University of Pennsylvania scientists whose prescient discovery science effort laid the foundation for swift vaccine development have been awarded the 2021 Lasker~DeBakey Clinical Medical Research Award.

24 Sep 2021

Peter Adams and Gerald Shadel receive NIH grant to explore the link between aging and liver cancer

Sanford Burnham Prebys professor Peter D. Adams, Ph.D., who directs the Aging, Cancer and Immuno-oncology Program and Salk Institute professor Gerald Shadel, Ph.D., who directs the San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging, have been awarded a grant from the NIH's National Institute on Aging for $13 million, funding a five-year project to explore the connection between aging and liver cancer.

24 Sep 2021

Scientists publish a detailed map of where human antibodies bind to SARS-CoV-2

Scientists at La Jolla Institute for Immunology (LJI) have published a detailed map of where human antibodies bind to SARS-CoV-2, a map that was generated by a global collaboration comparing nearly all leading clinical candidates.

24 Sep 2021

AI technique could lead to new ways to predict cancer prognosis and treatment response

Researchers and data scientists at UT Southwestern Medical Center and MD Anderson Cancer Center have developed an artificial intelligence technique that can identify which cell surface peptides produced by cancer cells called neoantigens are recognized by the immune system.

24 Sep 2021

Specific dietary guidelines may help people with bipolar disorders to better manage their health

Can specific dietary guidelines help people living with bipolar disorders better manage their health? Maybe someday, according to a new study by Penn State College of Medicine researchers. Clinical trial results showed that a diet designed to alter levels of specific fatty acids consumed by participants may help patients have less variability in their mood.

24 Sep 2021

Study identifies master regulator behind the development of antibody-producing cells

The master regulator behind the development of antibody-producing cells has been identified in a study by investigators at Weill Cornell Medicine. The findings provide new insight into the inner workings of the immune system and may help understand how tissues develop and how certain cancers arise.

24 Sep 2021

A daily pill to treat covid could be just months away, scientists say

Within a day of testing positive for covid-19 in June, Miranda Kelly was sick enough to be scared. At 44, with diabetes and high blood pressure, Kelly, a certified nursing assistant, was having trouble breathing, symptoms serious enough to send her to the emergency room.

24 Sep 2021

Infections impact blood vessel repair within the meninges following TBI or other cerebrovascular injuries

Viral Infection Slows Blood Vessel Repair After TBI: Seven days after mTBI, the blood vessels (stained in red) in the tissues around the brain are not completely repaired. A marker for intact vessels was used (labeled in green) to distinguish fully functional blood vessels (yellow) from ones that are still damaged (red).McGavern Lab, NINDS

24 Sep 2021

Melanomas that metastasize to the adrenal gland are resistant to checkpoint inhibitors

Recent advances in immunotherapy have allowed doctors at the University of Colorado Cancer Center to more effectively treat melanomas that spread to other parts of the body. Immunotherapy drugs such as checkpoint inhibitors, which are commonly used to treat melanomas, work to strengthen a patient's immune system so that it can prevent a tumor from "turning off" the ability of the immune system to fight it.

24 Sep 2021

Mathematical constructions of SARS-CoV-2 action could help fine-tune prevention and treatment

Mathematical constructions of the action of SARS-CoV-2 and its multiple spikes, which enable its success at infecting cells, can give vaccine developers and pharmaceutical companies alike a more precise picture of what the virus is doing inside us and help fine tune prevention and treatment, mathematical modelers say.

23 Sep 2021

Immune System News and Research

Defect in the interferon system associated with more severe COVID-19

Two proteins joined together using a free-standing, rigid link

BostonGene and MD Anderson collaborate to advance the development of multiplatform biomarker signatures

Primary sclerosing cholangitis: Therapy with synthetic bile acid acts directly on the immune system

Classic antidepressants show potential to enhance modern cancer treatments

Researchers identify key molecules that may help combat inflammatory diseases

mRNA COVID vaccines prove effective in the elderly

Penn scientists win 2021 Lasker Award for the discovery of therapeutic mRNA technology

Peter Adams and Gerald Shadel receive NIH grant to explore the link between aging and liver cancer

Scientists publish a detailed map of where human antibodies bind to SARS-CoV-2

AI technique could lead to new ways to predict cancer prognosis and treatment response

Specific dietary guidelines may help people with bipolar disorders to better manage their health

Study identifies master regulator behind the development of antibody-producing cells

A daily pill to treat covid could be just months away, scientists say

Infections impact blood vessel repair within the meninges following TBI or other cerebrovascular injuries

Melanomas that metastasize to the adrenal gland are resistant to checkpoint inhibitors

Mathematical constructions of SARS-CoV-2 action could help fine-tune prevention and treatment

Potential covalent SARS-CoV-2 spike protein inhibitors

COVID-19 vaccination and lactation

Design of mRNA vaccines to combat COVID-19

Understanding the DNA Damage Response in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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