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Key component of immune response is activated by short RNAs, shows study

Ludwig-Maximilians-Universitaet (LMU) in Munich researchers report that a central component of the innate immune response is activated by two short RNAs which are produced by site-specific cleavage of a precursor RNA molecule - and both derivatives are generated by the same enzyme.

3 Dec 2019

New findings regarding maintenance and functioning of the endosome

On a daily basis, multitudes of molecules enter each cell in our body. These can be nutrients or signal molecules or pathogenic microorganisms. An organelle in the cell directs these molecules to other stations for further processing.

3 Dec 2019

Virome analysis reveals clues for increased risk of type 1 diabetes in children

New results from The Environmental Determinants of Diabetes in the Young study show an association between prolonged enterovirus infection and the development of autoimmunity to the insulin-producing pancreatic beta-cells that precedes type 1 diabetes.

2 Dec 2019

Small molecule can induce self-destruction of pancreatic cancer cells, study finds

Pancreatic cancer is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed.

2 Dec 2019

Consortium launches ambitious project to transform the treatment of pain

In an effort to address the critical public health need for new, safer and more effective medicines to treat pain, a consortium based at the Laboratory of Systems Pharmacology at Harvard Medical School has launched an ambitious project titled STOP PAIN (Safe Therapeutic Options for Pain and Inflammation).

2 Dec 2019

Scientists discover new principle for activation of cancer genes

Researchers have long known that some genes can cause cancer when overactive, but exactly what happens inside the cell nucleus when the cancer grows has so far remained enigmatic.

2 Dec 2019

New molecular mechanism involved in the regulation of cholesterol movement in cells found

Researchers from the University of Barcelona and the August Pi i Sunyer Biomedical Research Institute found a new molecular mechanism involved in the regulation of the cholesterol movement in cells, an essential process for a proper cell functioning.

2 Dec 2019

New automated method helps identify cancer cell metabolism inhibitors

UCLA Jonsson Comprehensive Cancer Center researchers have developed a new automated method for testing hundreds of molecules at a time to find out which ones block cancer cells from consuming glucose - the sugars they need to spread and grow.

29 Nov 2019

ICR scientists carry out first comprehensive assessment of chemical probe resources

A new report urges biomedical researchers to use online web resources very carefully, taking into account their complementary benefits and weaknesses, when selecting small-molecule chemical probes to help answer their research questions.

28 Nov 2019

Leaky gut and space flight – the mechanism revealed

A new study on the effects of simulated microgravity, the condition that astronauts face in space, interferes with the epithelial barrier of the intestine, and the effect persists even after the astronaut returns to a normal environment. The research is published in the journal Scientific Reports.

28 Nov 2019

Researchers uncover the binding mechanism of opioid receptor

Together with colleagues from Shanghai, Brussels, Canada and the USA, researchers from the University of Bonn have uncovered the binding mechanism of an important pain receptor.

27 Nov 2019

New compound may enhance dengue vaccine efficacy by simulating amino acid deficiency

A new study published in the journal Science Signaling on November 26, 2019, describes a mouse experiment, in which the immune response to the dengue vaccine was boosted when the mice were first given halofuginone, a plant compound that is well known to herbalists.

27 Nov 2019

Researchers develop new strategy for treating the most aggressive type of brain cancer

Researchers from the University of São Paulo in Brazil have developed a strategy for treating the most aggressive type of brain cancer in adults that combines a photoactive molecule and a chemotherapeutic agent - both encapsulated in protein-lipid nanoparticles.

27 Nov 2019

CD44 protein helps identify mother cells responsible for aggressive nature of neuroblastoma

A group of researchers from the University of Seville and the Seville Biomedicine Institute (Instituto de Biomedicina de Sevilla - IBiS) has published a study in which they determine that a protein called CD44 makes it possible to identify the population of mother cells that are responsible for the aggressive nature and low survival rate of neuroblastoma, a type of childhood cancer that mainly affects children of two and three years old.

27 Nov 2019

New strategy could help cells get rid of disease-related debris

Tohoku University researchers have developed a strategy that could help cells get rid of disease-related debris. Further research could lead to treatments for neurodegenerative and metabolic diseases, Down syndrome, and maybe even aging-related diseases.

27 Nov 2019

Looking for the source: new routes for allergy treatment

A new multinational study has reported a very full account of the B lymphocytes that produce group E antibodies, also called IgE (Immunoglobulin E), that are behind allergic reactions, which are common in up to a third of the world’s population.

26 Nov 2019

Research shows how gut microbes affect stomach flu

A new study shows that gut microbes can modulate the severity of norovirus infection (the stomach flu, or the winter vomiting bug), based on the gut location first affected. Published in the journal Nature Microbiology on November 25, 2019, the study indicates new possibilities to treat norovirus infection.

26 Nov 2019

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

Oligomerix, Inc., a privately held company pioneering the development of tau oligomer inhibitors for Alzheimer's disease and related neurodegenerative disorders, and the Feinstein Institutes for Medical Research announced today the publication of preclinical data demonstrating that an oral small molecule drug inhibits the formation of neurotoxic tau oligomers in an animal model of tau aggregation most relevant to AD.

26 Nov 2019

International consortium to receive BRL 43.5 million for discovering drugs to treat neglected diseases

In the search for new drugs to treat neglected diseases and malaria, researchers at the University of Campinas and University of Sao Paulo will assemble a team of scientists in a global collaboration network co-funded by the São Paulo Research Foundation, the Drugs for Neglected Diseases initiative and the Medicines for Malaria Venture.

26 Nov 2019

Study reveals novel pathway to target colorectal cancer

While the emergence of precision medicine and immunotherapy has greatly improved outcomes for patients with colorectal cancer, new approaches are still needed for patients with late-stage disease who do not respond to these therapies.

26 Nov 2019

Molecule News and Research

Key component of immune response is activated by short RNAs, shows study

New findings regarding maintenance and functioning of the endosome

Virome analysis reveals clues for increased risk of type 1 diabetes in children

Small molecule can induce self-destruction of pancreatic cancer cells, study finds

Consortium launches ambitious project to transform the treatment of pain

Scientists discover new principle for activation of cancer genes

New molecular mechanism involved in the regulation of cholesterol movement in cells found

New automated method helps identify cancer cell metabolism inhibitors

ICR scientists carry out first comprehensive assessment of chemical probe resources

Leaky gut and space flight – the mechanism revealed

Researchers uncover the binding mechanism of opioid receptor

New compound may enhance dengue vaccine efficacy by simulating amino acid deficiency

Researchers develop new strategy for treating the most aggressive type of brain cancer

CD44 protein helps identify mother cells responsible for aggressive nature of neuroblastoma

New strategy could help cells get rid of disease-related debris

Looking for the source: new routes for allergy treatment

Research shows how gut microbes affect stomach flu

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

International consortium to receive BRL 43.5 million for discovering drugs to treat neglected diseases

Study reveals novel pathway to target colorectal cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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