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Liquid biopsy can help gauge the effectiveness of therapy for colorectal cancer

A new study from Washington University School of Medicine in St. Louis demonstrates that a liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread beyond the original tumor.

14 Feb 2021

Premature relaxation of restrictions following SARS-CoV-2 vaccination could lead to new mutations

A new preprint research paper posted to the medRxiv* server addresses the need to assess this risk by examining whether SARS-CoV-2 transmission can interact with vaccination rates to select vaccine-resistant strains. The study aims to provide data to shape effective countermeasures against the threat of viral resistance.

14 Feb 2021

New mouse model of SARS-CoV-2 infection reflects features of human infection

Now, a new preprint research paper posted to the bioRxiv server reports the development of a modified mouse model that allows productive SARS-CoV-2 infection of the mouse lungs, as well as the exploration of type I and III interferon responses in this condition.

14 Feb 2021

SARS-CoV-2's resistance to remdesivir in vitro

A new preprint research paper posted to the bioRxiv server discusses the emergence of mutations in the SARS-CoV-2 virus, allowing it to escape the effects of the most commonly used antiviral drug, remdesivir.

14 Feb 2021

SARS-CoV-2 was in NYC a good month before it was first identified, say researchers

Researchers at Icahn School of Medicine at Mount Sinai in New York have provided evidence suggesting that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – was infecting people in New York City (NYC) at least one month before the first case was officially documented in the city.

14 Feb 2021

Scientists identify genes involved in autoimmune Addison's disease

Novel genetic associations could pave the way for early interventions and personalized treatment of an incurable condition.

13 Feb 2021

New tool enables study of SARS-CoV-2 mutant spectrum by ultrasequencing

SARS-CoV-2 genome is three times larger than influenza genome. Both consist of NRA molecules that mutate when replicate.

13 Feb 2021

Scientists characterize genomic profile of 84 pediatric therapy-related myeloid neoplasms

Children treated for cancer with approaches such as chemotherapy can develop therapy-related myeloid neoplasms (a second type of cancer) with a dismal prognosis.

13 Feb 2021

Major antioxidant in green tea may increase levels of natural anti-cancer protein

An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells.

13 Feb 2021

A novel approach to suppress the growth of glioblastoma cells

Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing.

12 Feb 2021

Study offers new protocols for high-quality SARS-CoV-2 genomic sequencing

Researchers at the Southern Illinois University, U.S.A. have presented a comprehensive and well-validated set of working protocols for sequencing high-quality SARS-CoV-2 genomes in high throughput from patient samples.

12 Feb 2021

A brain enzyme plays an important role in waking up neural stem cells

Researchers studying an enzyme in fruit fly larvae have found that it plays an important role in waking up brain stem cells from their dormant 'quiescent' state, enabling them to proliferate and generate new neurons.

12 Feb 2021

Study reveals detailed map of glioblastoma in genetic, molecular detail

Glioblastoma is among the most aggressive and devastating of cancers. While rare compared with other cancers, it's the most common type of brain cancer.

12 Feb 2021

Study addresses multiple challenges of the pathogenesis of Huntington's disease

Recent genetic data from patients with Huntington's disease (HD) show that DNA repair is an important factor that determines how early or late the disease occurs in individuals who carry the expanded CAG repeat in the HTT gene that causes HD.

12 Feb 2021

Portable suitcase lab for rapid detection of SARS-CoV-2

The PCR test is the most accurate tool to identify SARS-CoV-2. However, valid results are often available only after days.

12 Feb 2021

New SARS-CoV-2 variant found in newborn child with seizures in the United States

Researchers at a hospital in Washington D.C. found a new mutant strain of the virus in a neonatal patient with high viral loads. According to the authors, this strain could be spreading in the United States mid-Atlantic population and needs monitoring.

11 Feb 2021

Lifestyle changes in pregnant women linked to epigenetic alterations in babies

A study led by researchers at Lund University in Sweden showed a connection between lifestyle intervention in pregnant women with obesity and epigenetic alterations in the baby. The study is published in the journal Diabetes.

11 Feb 2021

New genetic analysis reveals biological causes of muscle weakness in older people

A new largescale genetic analysis has found biological mechanisms that contribute to making people more susceptible to muscle weakness in later life, finding that diseases such as osteoarthritis and diabetes may play a large role in susceptibility.

11 Feb 2021

SARS-CoV-2 evolves antibody resistance in immunocompromised patient

Researchers in the United States who tracked the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised patient found that convalescent plasma therapy was associated with the emergence of viral variants that were less susceptible to neutralizing antibodies.

11 Feb 2021