immunity News and Research

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Single-dose vaccines may provide sufficient immunization for individuals previously infected with SARS-CoV-2

A group of researchers based at the Papa Giovanni XXIII hospital in Italy have submitted evidence to suggest that individuals previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may adequately benefit from a single dose of mRNA vaccine, rather than requiring the current two-vaccine regimen.

12 Mar 2021

Natural virus-induced immunity protective against UK and South African SARS-CoV-2 variants in hamster study

As new variants of SARS-CoV-2 continue to emerge, fueling the continued spread of the COVID-19 pandemic, a new study offers encouragement.

12 Mar 2021

Impact of type I interferon (IFN) autoantibodies in critical COVID-19

A new preprint discusses the pathogenesis of this critical COVID-19 with reference to autoimmune phenomena involving the key antiviral type I interferon pathway.

12 Mar 2021

Antibodies to SARS-CoV-2 spike protein and RBD detected in saliva of mRNA-vaccine recipients

A team of researchers from the US and the Netherlands recently reported that antibodies to the spike protein and the RBD are detected in saliva samples from healthcare workers vaccinated with mRNA vaccines.

12 Mar 2021

SARS-CoV-2 is extremely sensitive to type I IFN pre-treatment, study finds

Researchers have found that SARS-CoV-2 is extremely sensitive to type I IFN pre-treatment. Therefore, strategies such as focusing on limiting the production of IFN, rather than its function, could restrict the mechanism of SARS-CoV-2 that increases its viral load with delayed or absent symptoms.

12 Mar 2021

Living in neighborhoods with high rates of violence and poverty alters gene activity

The chronic stress of living in neighborhoods with high rates of violence and poverty alters gene activity in immune cells, according to a new study of low-income single Black mothers on the South Side of Chicago.

12 Mar 2021

Delaying second dose of Pfizer-BioNTech SARS-CoV-2 vaccine may be feasible in some cases

Researchers in Spain have conducted the most extensive study to date investigating the effectiveness of vaccinating healthcare workers with a single dose of the Pfizer-BioNTech vaccine to protect against coronavirus disease 2019 (COVID-19).

11 Mar 2021

Study addresses glycosylation concerns in SARS-CoV-2 vaccine design

An international team of researchers has found that glycosylation patterns are conserved across the native spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – and the recombinant spike proteins made in laboratories for use in vaccines.

11 Mar 2021

People previously infected with SARS-CoV-2 may achieve immunity after one mRNA vaccine dose, finds study

A team of researchers led by Thomas W. McDade of Northwestern University suggests people who were previously infected with SARS-CoV-2, the causative agent of COVID-19, may require only one dose of the mRNA vaccine to obtain immunity.

11 Mar 2021

Researchers develop assay for qualitative assessment of SARS-CoV-2 neutralizing antibodies

To address the need for a high-quality neutralization assay against SARS-CoV-2, researchers from the NIAID modified and optimized a previously established fluorescence reduction neutralization assay (FRNA) to provide a quantitative assessment of a large number of infected cells through the use of a high-content imaging system.

11 Mar 2021

Nanobody works against all SARS-CoV-2 variants of concern in animal model

Researchers based in Belgium have developed a new antibody drug that is highly successful at neutralizing coronavirus disease 2019 (COVID-19) in Syrian hamsters. The new biologic was administered to the rodents and was found to be equally successful at neutralizing the original severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain, and also the new mutant variants, such as the South African and UK strains.

11 Mar 2021

Study: Lowering the activity of KRAS gene can help fight pancreatic cancer

If clinicians could stop mutations of the KRAS gene in pancreatic cancer – which happens in more than 90 percent of pancreatic cancer cases and drastically reduces response to immunotherapy – the chances of improving treatment for this deadly form of cancer would be increased.

11 Mar 2021

Brazil COVID variant 2.5 times more transmissible than ancestral strain

In early January 2021, a new variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified from travelers returning from Brazil. This variant, referred to as “P.1”, likely emerged in early-to-late November 2020, and subsequently spread throughout Manaus, the state capital of Amazonas, Brazil, over the following December.

11 Mar 2021

Researcher find an emergent SARS-CoV-2 variant in California

Researchers have found a new SARS-CoV-2 variant in California, USA. This variant is more transmissible than circulating strains but slightly less transmissible than the new N501Y variant and moderately resistant to antibodies in convalescent sera and mRNA vaccines.

10 Mar 2021

Researchers characterize antibody responses to COVID-19 mRNA-based vaccine

A team of scientists from the USA and Canada has recently characterized the antibodies developed against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in response to an mRNA-based coronavirus disease 2019 (COVID-19) vaccine.

10 Mar 2021

What childhood vaccine rates can, and can’t, teach us about Covid vaccines

Polls show Americans are increasingly interested in getting vaccinated against Covid-19, but such surveys are largely national, leaving a big question: When the vaccines become available to the general public, will enough people get it in your county, city or neighborhood to keep your community safe?

10 Mar 2021

Single mRNA vaccine dose may be enough for those previously exposed to SARS-CoV-2

New research supports the notion that those who have recovered from COVID-19, caused by SARS-CoV-2 infection, may only need one dose of an mRNA vaccine to boost immunity.

10 Mar 2021

mRNA COVID-19 vaccines show high efficacy in pregnancy and lactation

A reassuring study reports the immunogenicity and lack of reactogenicity of the coronavirus disease 2019 (COVID-19) vaccine when given to this group of subjects. This will contribute to the sum of knowledge about the implications of vaccination in this high-risk cohort.

10 Mar 2021

How likely is SARS-CoV-2 reinfection?

The coronavirus disease 2019 (COVID-19) pandemic has already caused over 117.6 million confirmed cases the world over. Yet, researchers debate the exact incidence of reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19’s causative pathogen.

10 Mar 2021

Pfizer COVID-19 vaccine elicits antibodies in blood and breastmilk simultaneously, finds study

A new study adds to the sum of knowledge around this issue, showing a highly synchronized and rapid development of an antibody response in breast milk and serum, which reached stable levels around two weeks after the second dose of the vaccine was administered.

10 Mar 2021

immunity News and Research

Single-dose vaccines may provide sufficient immunization for individuals previously infected with SARS-CoV-2

Natural virus-induced immunity protective against UK and South African SARS-CoV-2 variants in hamster study

Impact of type I interferon (IFN) autoantibodies in critical COVID-19

Antibodies to SARS-CoV-2 spike protein and RBD detected in saliva of mRNA-vaccine recipients

SARS-CoV-2 is extremely sensitive to type I IFN pre-treatment, study finds

Living in neighborhoods with high rates of violence and poverty alters gene activity

Delaying second dose of Pfizer-BioNTech SARS-CoV-2 vaccine may be feasible in some cases

Study addresses glycosylation concerns in SARS-CoV-2 vaccine design

People previously infected with SARS-CoV-2 may achieve immunity after one mRNA vaccine dose, finds study

Researchers develop assay for qualitative assessment of SARS-CoV-2 neutralizing antibodies

Nanobody works against all SARS-CoV-2 variants of concern in animal model

Study: Lowering the activity of KRAS gene can help fight pancreatic cancer

Brazil COVID variant 2.5 times more transmissible than ancestral strain

Researcher find an emergent SARS-CoV-2 variant in California

Researchers characterize antibody responses to COVID-19 mRNA-based vaccine

What childhood vaccine rates can, and can’t, teach us about Covid vaccines

Single mRNA vaccine dose may be enough for those previously exposed to SARS-CoV-2

mRNA COVID-19 vaccines show high efficacy in pregnancy and lactation

How likely is SARS-CoV-2 reinfection?

Pfizer COVID-19 vaccine elicits antibodies in blood and breastmilk simultaneously, finds study

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