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MGH researchers discover that macrophages contribute to untreatable type of heart failure

A team of Massachusetts General Hospital investigators has discovered, for the first time, that the immune cells called macrophages contribute to a type of heart failure for which there currently is no effective treatment.

14 Feb 2018

Report identifies potentially modifiable factors that may contribute to persistent risk of SUID

An analysis of trends in sudden unexpected infant death (SUID) over the past two decades finds that the drop in such deaths that took place following release of the 1992 American Academy of Pediatrics (AAP) "back to sleep" recommendations, did not occur in infants in the first month of life.

14 Feb 2018

Pfizer to use BC Platforms’ technology solutions to analyze data in cardiovascular diseases

BC Platforms, a world leader in genomic data management and analytics, today announces that Pfizer Finland will be using its technology solutions and research platform, including BCRQUEST.COM, to study data in cardiovascular diseases.

14 Feb 2018

Surgical infection in low-income nations linked to drug-resistant bacteria, research suggests

Patients having surgery in low-income countries are more likely to develop an infection than those in wealthier nations, which may be linked to drug-resistant bacteria, research led by the Universities of Birmingham, Edinburgh and Warwick suggests.

14 Feb 2018

Pioneering research could provide novel insight into how genomic information is read

Pioneering new research could offer a fascinating new insight into how genomic information is read. The human genome contains thousands of genes, but to get the information from a gene requires it to be copied.

13 Feb 2018

Hints to aging lurk in fruit flies’ germline stem cells

Little hints of immortality are lurking in the stem cells of fruit flies. Stem cells that produce sperm use a genetic trick to stay perpetually young across generations, researchers at the University of Michigan Life Sciences Institute have discovered. Certain sections of the fruit fly genome get shorter with age. But remarkably, some reproductive cells can repair the shrinkage, the researchers report in the journal eLife.

13 Feb 2018

Scientists suggest new strategy to inhibit untreatable, deadly nerve sheath tumors

Genomic profiling of mostly untreatable and deadly nerve sheath tumors led scientists to test a possible therapeutic strategy that inhibited tumor growth in lab tests on human tumor cells and mouse models, according to research in the journal Cancer Cell.

13 Feb 2018

Tissue-specific changes in gene expression can help predict time of death

International team of scientists led by Roderic Guigó at the Centre for Genomic Regulation in Barcelona showed that changes in gene expression in different tissues triggered by death can be used to predict the time of death of an individual.

13 Feb 2018

Study reports longer survival for obese men with metastatic melanoma

Obese patients with metastatic melanoma who are treated with targeted or immune therapies live significantly longer than those with a normal body mass index, investigators report in a study published in Lancet Oncology of 1,918 patients in six independent clinical cohorts.

13 Feb 2018

PAREXEL launches new service to optimize management of human biological samples

PAREXEL International Corporation, the world’s leading innovator of biopharmaceutical services, today launched its Biological Sample Lifecycle Management service, enabling optimal use of human biological samples.

From Parexel 13 Feb 2018

Before-school physical activity program leads to improvement in body weight, wellness of children

Children participating in a 12-week, before-school physical activity program experienced improvement in body weight and social/emotional wellness, compared with their classmates who did not participate.

12 Feb 2018

Scientists develop new array to identify biomarkers for wide range of diseases

Scientists have developed a way to identify biomarkers for a wide range of diseases by assessing the antibodies we are making to the complex sugars coating our cells.

12 Feb 2018

Undergraduate researcher discovers genes linked to glioblastoma

When Leland Dunwoodie, an undergraduate researcher in biochemistry, approached his PI about wanting to start research on "some human stuff" in the spring of 2016, he didn't imagine it would lead to the discovery of 22 genes that are implicated in glioblastoma, the most aggressive type of brain cancer.

9 Feb 2018

Using CRISPR To Produce Induced Pluripotent Stem Cells

An interview with Dr. Sheng Ding about using a modified version of the CRISPR-Cas9 system to produce induced pluripotent stem cells.

9 Feb 2018

Scientists develop ultrasound-propelled nanomotors for active delivery of Cas9-sgRNA complex

In cancer research, the “Cas-9–sgRNA” complex is an effective genomic editing tool, but its delivery across the cell membrane to the target (tumor) genome has not yet been satisfactorily solved. American and Danish scientists have now developed an active nanomotor for the efficient transport, delivery, and release of this gene scissoring system.

9 Feb 2018

Compounds isolated from rattlesnake's venom show promise to fight against hepatitis C

A group of Brazilian scientists achieved promising results using isolated compounds from the venom of the South American rattlesnake in combat of hepatitis C.

8 Feb 2018

Researchers describe human blood-nerve barrier transcriptome for the first time

Human peripheral nerves -- all the nerves outside of the central nervous system -- are protected by the blood-nerve barrier. This is a tight covering of endothelial cells that maintains the microenvironment within the nerves by restricting the amounts or types of water, ions, solutes and nutrients that can reach the axons, or electric cables within the nerves, from the blood circulation system.

8 Feb 2018

Researchers identify presence of ER gene fusion proteins in treatment-resistant breast cancer

At Magee-Womens Research Institute and UPMC Hillman Cancer Center, a large team of clinical and laboratory researchers dedicated to understanding treatment resistance in the most common form of breast cancer have identified a new genetic change in the estrogen receptor that contributes to therapy resistance.

7 Feb 2018

Researchers solve crystal structure for enzyme that plays key role in DNA methylation

A research team led by a biochemist at the University of California, Riverside has solved the crystal structure for an enzyme that plays a key role in DNA methylation, the process by which methyl groups are added to the DNA molecule.

7 Feb 2018

New CRISPR gene-editing technique can correct majority of mutations that cause DMD

Scientists have developed a CRISPR gene-editing technique that can potentially correct a majority of the 3,000 mutations that cause Duchenne muscular dystrophy (DMD) by making a single cut at strategic points along the patient's DNA, according to a study from UT Southwestern Medical Center.

6 Feb 2018

Genomic News and Research

MGH researchers discover that macrophages contribute to untreatable type of heart failure

Report identifies potentially modifiable factors that may contribute to persistent risk of SUID

Pfizer to use BC Platforms’ technology solutions to analyze data in cardiovascular diseases

Surgical infection in low-income nations linked to drug-resistant bacteria, research suggests

Pioneering research could provide novel insight into how genomic information is read

Hints to aging lurk in fruit flies’ germline stem cells

Scientists suggest new strategy to inhibit untreatable, deadly nerve sheath tumors

Tissue-specific changes in gene expression can help predict time of death

Study reports longer survival for obese men with metastatic melanoma

PAREXEL launches new service to optimize management of human biological samples

Before-school physical activity program leads to improvement in body weight, wellness of children

Scientists develop new array to identify biomarkers for wide range of diseases

Undergraduate researcher discovers genes linked to glioblastoma

Using CRISPR To Produce Induced Pluripotent Stem Cells

Scientists develop ultrasound-propelled nanomotors for active delivery of Cas9-sgRNA complex

Compounds isolated from rattlesnake's venom show promise to fight against hepatitis C

Researchers describe human blood-nerve barrier transcriptome for the first time

Researchers identify presence of ER gene fusion proteins in treatment-resistant breast cancer

Researchers solve crystal structure for enzyme that plays key role in DNA methylation

New CRISPR gene-editing technique can correct majority of mutations that cause DMD

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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