Cachexia News and Research

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Cachexia is a condition which denotes the excessive loss of weight. It occurs because of the depletion of adipose tissue and muscle mass in people who are not trying to lose weight.

Discovery of key protein for burning fat may lead to obesity treatments

Obesity, which affects 650 million people worldwide, influences the development of cardiometabolic diseases and increases the risk of cancer.

13 Jan 2025

Developing and refining muscle atrophy models for drug discovery

With the intensification of global population aging, muscle atrophy, characterized by the loss of muscle mass and function, has become an important health issue affecting the elderly. Researchers have widely used various animal and cellular models to gain a deeper understanding of the pathophysiological mechanisms of muscle atrophy and develop effective treatment strategies.

9 Jan 2025

University of Oklahoma professor honored with prestigious Palade Prize for pancreatic cancer research

Min Li, Ph.D., a George Lynn Cross Professor of Medicine, Surgery and Cell Biology at the University of Oklahoma College of Medicine and Associate Director for Global Oncology at OU Health Stephenson Cancer Center, will receive the 2024 Palade Prize from the International Association of Pancreatology.

26 Nov 2024

Long-term sedentary behavior raises blood pressure in youth

Time spent sedentary beyond six hours per day during growth from childhood through young adulthood may cause an excess increase of 4 mmHg in systolic blood pressure, a new study shows.

14 Nov 2024

Cachexia diagnosis criteria affect cancer patient survival rates

Maintaining good health and well-being is crucial for how well patients respond to cancer treatments. Unfortunately, cachexia, or involuntary weight loss, is a major concern for many individuals with advanced cancer.

6 Nov 2024

Researchers identify genes linked to muscle aging and sarcopenia

Scientists have identified previously unreported genes which appear to play a key role in the muscle ageing process.

26 Oct 2024

Physical tests offer prognostic insights for lung cancer patients

A study of patients with metastatic lung cancer by researchers based in Brazil and the United States has found that their performance in simple physical tests such as sitting down, standing and walking can help physicians arrive at a prognosis and approach to treatment.

22 Oct 2024

New discovery could lead to improved treatments for age- and cancer-related muscle degeneration

With the global population aging rapidly, sarcopenia, a condition that affects millions of older adults and severely diminishes their quality of life, is emerging as an urgent public health issue.

26 Sep 2024

Drug breakthrough provides new hope for cancer patients with cachexia

Researchers discovered a drug that safely and effectively helped cancer patients when they suffered from cachexia (ku-KEK-see-uh), a common condition related to cancer that involves weight loss and muscle wasting.

19 Sep 2024

Rare genetic mutation tied to increased risk of tuberculosis

Tuberculosis is a confounding scourge. It's the leading cause of death from infectious disease in the world, and yet it's estimated that those deaths represent perhaps 5% of infections with Mycobacterium tuberculosis (Mtb).

30 Aug 2024

Blocking IL-6 in the brain to treat cancer cachexia

Cancer is insidious. Throughout tumor progression, the disease hijacks otherwise healthy biological processes - like the body's immune response - to grow and spread.

8 Jul 2024

Study reveals individual differences in fasting-induced ketosis and its health benefits

The study reveals that long-term fasting-induced ketosis varies among individuals and is influenced by factors like age, gender, and physical activity. It can also guide personalized fasting strategies.

16 Jun 2024

DELiVR's virtual reality training speeds up cell detection in complex brain datasets

Efficient neuronal activity detection in brain imaging.

25 Apr 2024

The whey to go: Researchers unlock the potential of whey-derived proteins for cancer prevention

The current evidence regarding the significance of whey protein for cancer prevention and treatment.

4 Apr 2024

Lactate's role in driving cancer cachexia uncovered

Study highlights the significant role of lactate in promoting cancer cachexia via activation of the adipose-specific G-protein-coupled receptor 81 (GPR81), suggesting new therapeutic targets for this condition.

20 Mar 2024

Unlocking vitamin B6's role in pancreatic cancer and immune system battle

Vitamin B6 is beneficial in many ways, notably for its role in maintaining a strong immune system. However, when pancreatic cancer develops, its cells also need vitamin B6 to replicate.

23 Feb 2024

How African sleeping sickness melts away body fat: New study sheds light on the role of lipolysis

Researchers find that the T. brucei parasite, responsible for African trypanosomiasis, triggers weight loss by disrupting fat cell lipolysis. The study shows that ATGL enzyme is key to this process, potentially offering a new angle for future research and treatment.

17 Oct 2023

Plant-based proteins boost muscle mass and cut fat in older adults

Plant-based proteins are just as effective as animal-based options in maintaining muscle mass and strength in older adults, a new meta-analysis finds. The study shows that plant proteins can even aid in reducing fat mass, offering a sustainable and healthful option for combating age-related muscle decline.

24 Sep 2023

Molecular insights into drug-induced GDF15 regulation in cancer cells and cardiomyocytes: implications for precision medicine

A recent study elucidated the molecular mechanisms of drug-induced regulation of growth differentiation factor 15 (GDF15).

1 Aug 2023

KIAA0930 could be a novel therapeutic target for cancer cachexia

A new research paper was published in Oncotarget's Volume 14 on July 20, 2023, entitled, "The uncharacterized transcript KIAA0930 confers a cachexic phenotype on cancer cells."

26 Jul 2023