Cytochrome P450 News and Research

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Optibrium’s Quantum Mechanics and Machine Learning Methods Predict Routes of Drug Metabolism

Peer-reviewed study published in Xenobiotica describes an innovative new method that predicts the routes and products of Phase I and II metabolism with high sensitivity and greater precision than other approaches.

From Optibrium Ltd. 7 Dec 2023

Pharmacogenomics holds promise for personalized dementia therapies

Pharmacogenomics-based studies in the research for personalized therapeutics for dementia

8 Nov 2023

Coffee and genetics: A complex blend impacting kidney health

Researchers dive into the intricate connection between caffeine consumption and genetic predisposition, uncovering paradoxical effects on kidney function.

22 Oct 2023

Wood cookstove use linked to gastric cancer risk

Researchers conducted a population-based study with a case–control design in rural areas of Honduras in Central America to examine whether wood cookstove use by indigenous populations was associated with increased risk of stomach cancers, including gastric adenocarcinoma.

4 Oct 2023

New research reveals how social isolation impacts behavior and lifespan in social species

Researchers used Camponotus fellah (carpenter ants) as a model species to perform behavioral tracking and ribonucleic acid-sequencing (RNA-seq) to study the transcriptome-level differences between socially isolated workers versus workers in groups.

29 Sep 2023

UTSA researchers study the mechanism of action of Sweet Annie's medicinal compounds

Vibrant green leaves sprout from tall fragrant plants sitting neatly in two rows of terracotta pots in Valerie Sponsel's UTSA biology laboratory.

8 Sep 2023

Non-alcoholic steatohepatitis progression blocked by ginger essential oil

Researchers explore the potential utility of ginger essential oil in preventing NASH.

29 Aug 2023

Cytochromes P450 enzymes exhibit unique soft-robotic properties, study reveals

Study reveals an important discovery in the realm of nanomachines within living systems.

8 Aug 2023

Understanding the mechanisms behind rising antifungal drug resistance

In a recent study, researchers addressed the issue of the rise of antifungal drugs-resistant infections and the advent of multidrug-resistant fungal pathogens.

19 Jul 2023

AMP releases consensus recommendations for CYP3A4 and CYP3A5 genotyping assays

The Association for Molecular Pathology (AMP), the premier global molecular diagnostic professional society, today published consensus recommendations to aid in the design and validation of clinical CYP3A4 and CYP3A5 genotyping assays, promote standardization of testing across different laboratories, and improve patient care.

10 Jul 2023

Tumors in distant organs remotely reprogram the liver

Cancers often release molecules into the bloodstream that pathologically alter the liver, shifting it to an inflammatory state, causing fat buildup and impairing its normal detoxifying functions, according to a study from investigators at Weill Cornell Medicine.

25 May 2023

Is there an association between long-term plasma caffeine intake and adiposity, type 2 diabetes, and cardiovascular diseases?

Investigate the effects of long-term exposure to higher plasma caffeine concentrations on T2D, adiposity, and cardiovascular diseases.

18 May 2023

Are quaternary ammonium compounds associated with adverse environmental and health outcomes?

Researchers presented an overview of quaternary ammonium compounds and their environmental and human health concerns.

11 May 2023

Does oral exposure to cannabidiol (CBD) have toxic implications?

Researchers reviewed the implications of oral exposure to cannabidiol (CBD).

25 Apr 2023

Study should spur the development of alternative range of anti-TB inhibitors

Tuberculosis (TB) is one of the deadliest infectious diseases worldwide that is spread in the air like the common cold. TB is caused by the bacterium Mycobacterium tuberculosis (Mtb) and was responsible for approximately 1.6 million deaths in 2021.

20 Apr 2023

Despite raising LDL levels, coffee lowers systolic and diastolic blood pressure

Researchers performed a cross-sectional analysis of the general population of Hamburg City, Germany.

27 Mar 2023

Higher plasma caffeine concentrations might reduce body fat and type 2 diabetes risk

In a recent study published in the journal BMJ Medicine, researchers in the United Kingdom and Sweden investigated the probable causality of long-term serum caffeine concentrations on type 2 diabetes (T2D), adiposity, and major cardiovascular diseases (CVDs).

22 Mar 2023

Cytochrome P450 News and Research

Optibrium’s Quantum Mechanics and Machine Learning Methods Predict Routes of Drug Metabolism

Pharmacogenomics holds promise for personalized dementia therapies

Coffee and genetics: A complex blend impacting kidney health

Wood cookstove use linked to gastric cancer risk

New research reveals how social isolation impacts behavior and lifespan in social species

UTSA researchers study the mechanism of action of Sweet Annie's medicinal compounds

Non-alcoholic steatohepatitis progression blocked by ginger essential oil

Cytochromes P450 enzymes exhibit unique soft-robotic properties, study reveals

Understanding the mechanisms behind rising antifungal drug resistance

AMP releases consensus recommendations for CYP3A4 and CYP3A5 genotyping assays

Tumors in distant organs remotely reprogram the liver

Is there an association between long-term plasma caffeine intake and adiposity, type 2 diabetes, and cardiovascular diseases?

Are quaternary ammonium compounds associated with adverse environmental and health outcomes?

Does oral exposure to cannabidiol (CBD) have toxic implications?

Study should spur the development of alternative range of anti-TB inhibitors

Despite raising LDL levels, coffee lowers systolic and diastolic blood pressure

Higher plasma caffeine concentrations might reduce body fat and type 2 diabetes risk

Next-gen Mpro inhibitor: Promising new drug candidate against Omicron and other SARS-CoV-2 variants

A high-throughput CAMP assay for the evaluation of the vitamin D-dependent antimicrobial response

Study finds high doses of oral CBD can exacerbate THC’s effects by inhibiting THC metabolism

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®