Endoplasmic reticulum (ER) News and Research

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Surprising new role for a key immune regulator revealed

A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

3 Aug 2023

Reversing β-cell failure: A promising approach for type 2 diabetes treatment

Researchers examined current evidence on the reasons and implications of pancreatic beta-cell failure.

3 Aug 2023

Study reveals potential target for repairing beta-cell dysfunction in Type 2 diabetes

Researchers used a murine model to demonstrate that functional excision of murine PITPNA eventually led to hyperglycemia in mice.

19 Jul 2023

New insights into how dendritic cells arm T cells to fight disease

As part of the immune system, dendritic cells are essential for fighting body cells that have degenerated or are infected with a virus.

11 Jul 2023

Deciphering a biochemical mechanism explains the center of protein factories

Based on genetic blueprints, individual amino acids are assembled into long amino acid chains, the proteins, in the protein factories of our cells, the ribosomes. Each newly formed protein starts with the amino acid methionine.

23 Jun 2023

SARS-CoV-2 hijacks body's metabolism to amplify COVID-19 severity

In a review article published in the journal Signal Transduction and Targeted Therapy, scientists have discussed host metabolic alteration triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its effect on disease severity.

9 Jun 2023

Defective proteins involved in ER-phagy can cause neurodegenerative diseases

Our cells are crisscrossed by a system of membrane tubes and pockets called the endoplasmic reticulum (ER). It is crucial for the production of biomolecules and is continuously built up and degraded.

26 May 2023

The role of diet in managing type 2 diabetes: insights into individualized medical nutritional therapy

Researchers investigated the use of medical nutrition therapy for type 2 diabetes mellitus patients.

2 May 2023

Shedding light on diabetes: Vitamin D's crucial role in insulin regulation and disease prevention

Research discusses the role of vitamin D in both type 1 and type 2 diabetes pathogenesis. It summarizes the molecular mechanisms of vitamin D in insulin secretion, insulin sensitivity, and immunity, as well as the observational and interventional human studies investigating the use of vitamin D as a treatment for diabetes.

25 Apr 2023

UH researcher examines the causes of skeletal muscle atrophy

Skeletal muscle atrophy, or wasting, is a devastating and often irreversible syndrome during the aging process and for patients with advanced cancer.

11 Apr 2023

Researchers unlock the molecular basis behind fastest biological movement of single-celled eukaryotes

In his famous letter to the Royal Society dated Oct. 9, 1676, Antonie van Leeuwenhoek described a single-celled eukaryote (Vorticella) and its fascinating ultrafast cell contraction as the first set of discoveries.

22 Feb 2023

Molecular switch regulates autophagy in plants

Autophagy, or "self-eating", is an essential cellular quality control mechanism that clears the cell of protein aggregates and damaged organelles. This mechanism is inactive under normal conditions and only triggered upon persistent cellular stress.

10 Feb 2023

Study shows the modulatory effect of resistance training on the endoplasmic reticulum in older adults

Aging involves a balance between oxidants and antioxidants, low-grade inflammation and a protein response that occurs at the cellular level, which is responsible for many health disorders.

17 Jan 2023

The metabolic links between diet-induced changes in the gut and NASH

Scientists reviewed the metabolic association between diet-induced alterations in the gut and NASH

4 Jan 2023

Researchers discover previously unknown mechanism for how 'starvation response' is triggered

Body cells burn off fat reserves when nutrient supply from food ceases. A team led by Professor Volker Haucke and Dr. Wonyul Jang from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) has now discovered a previously unknown mechanism for how this “starvation response” is triggered, and what can inhibit it.

15 Dec 2022

mRNA-FISH for the detection of viral RNA in SARS-CoV-2 infected cells and the determination of the kinetics of early RNA replication

Researchers evaluated the early replication kinetics of SARS-CoV-2.

15 Dec 2022

Endoplasmic reticulum (ER) News and Research

Surprising new role for a key immune regulator revealed

Reversing β-cell failure: A promising approach for type 2 diabetes treatment

Study reveals potential target for repairing beta-cell dysfunction in Type 2 diabetes

New insights into how dendritic cells arm T cells to fight disease

Deciphering a biochemical mechanism explains the center of protein factories

SARS-CoV-2 hijacks body's metabolism to amplify COVID-19 severity

Defective proteins involved in ER-phagy can cause neurodegenerative diseases

The role of diet in managing type 2 diabetes: insights into individualized medical nutritional therapy

Shedding light on diabetes: Vitamin D's crucial role in insulin regulation and disease prevention

UH researcher examines the causes of skeletal muscle atrophy

Researchers unlock the molecular basis behind fastest biological movement of single-celled eukaryotes

Molecular switch regulates autophagy in plants

Study shows the modulatory effect of resistance training on the endoplasmic reticulum in older adults

The metabolic links between diet-induced changes in the gut and NASH

Researchers discover previously unknown mechanism for how 'starvation response' is triggered

mRNA-FISH for the detection of viral RNA in SARS-CoV-2 infected cells and the determination of the kinetics of early RNA replication

Glycan signatures in rheumatic diseases and their associated functional implications

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

Utilizing marine sources to extract DHA to treat Alzheimer’s

What is the impact of SARS-CoV-2 on HIV-1 infectivity?

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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