Frontotemporal Dementia News and Research

RSS

UCSF discovery points to new strategies for Alzheimer's treatment

UCSF scientists have discovered how microglia engulf and break down amyloid beta, a protein that builds up in Alzheimer's, with devastating consequences for the brain.

28 Jul 2025

APOE ε4 variant reveals hidden risk factors beyond Alzheimer’s

Researchers discovered that people carrying the APOE ε4 gene variant share a unique immune-related protein signature across their blood, brain, and cerebrospinal fluid—regardless of neurodegenerative disease diagnosis. This signature reveals a fundamental, disease-independent vulnerability linked to APOE ε4, reframing our understanding of genetic risk in conditions like Alzheimer's, Parkinson’s, ALS, and FTD.

21 Jul 2025

New AI tool helps clinicians identify brain activity patterns linked to nine types of dementia

Mayo Clinic researchers have developed a new artificial intelligence (AI) tool that helps clinicians identify brain activity patterns linked to nine types of dementia, including Alzheimer's disease, using a single, widely available scan - a transformative advance in early, accurate diagnosis.

3 Jul 2025

Glycogen metabolism in neurons emerges as key to fighting Alzheimer's

A new study from scientists at the Buck Institute for Research on Aging has revealed a surprising player in the battle against Alzheimer's disease and other forms of dementia: brain sugar metabolism.

1 Jul 2025

New AI tool helps clinicians identify brain activity patterns linked to nine types of dementia

30 Jun 2025

UK study finds small proportion of early Alzheimer’s patients suitable for latest treatments

Few people in the UK with early stage Alzheimer's disease are likely to be suitable for the latest drugs which aim to halt progress of the condition, yet many are nevertheless likely to be referred for these treatments, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

13 Jun 2025

UC Irvine researchers uncover altered RNA processing in ALS

UC Irvine researchers conducted a study to better understand the molecular basis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder in which patients lose the ability to move, becoming weak and wheelchair bound before dying because they can no longer breathe.

3 Jun 2025

Epileptic seizures more common in frontotemporal dementia patients than previously known

According to a recent study, in patients with frontotemporal dementia (FTD), epileptic seizures are significantly more common than previously known.

2 Jun 2025

Stress granules play a protective role against neurodegenerative disease

Scientists from St. Jude Children's Research Hospital and Washington University in St. Louis report mechanistic insights into the role of biomolecular condensation in the development of neurodegenerative disease.

28 May 2025

Herpes virus infection linked to higher Alzheimer’s risk, study shows antiherpetic drugs may help

A large US case-control study found that people diagnosed with herpes simplex virus type 1 (HSV-1) had a higher risk of developing Alzheimer’s disease. Use of antiherpetic medications was associated with a reduced risk of Alzheimer’s in those with HSV-1.

21 May 2025

Study offers new clues to early detection of frontotemporal dementia in middle age

Dementia usually affects older people, so when it occurs in middle age, it can be hard to recognize. The most common form is frontotemporal dementia (FTD), which is often mistaken for depression, schizophrenia, or Parkinson's disease before the correct diagnosis is reached.

16 May 2025

Early detection of primary progressive aphasia through speech and hearing tests

Difficulty finding words or the habit of substituting them with others that are similar semantically – such as knife and cutter – or phonologically – such as knife and wife – are usually the first symptoms of a type of dementia known as primary progressive aphasia (PPA).

30 Apr 2025

TDP-43 dysfunction in brain blood vessels may drive Alzheimer's and ALS progression

Reduced levels of a critical protein are linked to devastating brain diseases like Alzheimer's, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Surprisingly, the protein shortage primarily affects the brain's blood vessels.

30 Apr 2025

Both low and moderate-high intensity exercise could help fight against Alzheimer's

Researchers at University of California San Diego and Wake Forest University have found that both low and moderate-high intensity exercise could be valuable tools in the fight against Alzheimer's.

24 Apr 2025

New approach may prevent neurotoxic protein aggregates in ALS

Researchers at Goethe University, Johannes Gutenberg University Mainz and Kiel University discover possible method for preventing protein aggregates – Cluster4Future PROXIDRUGS research project.

23 Apr 2025

Emotional empathy may be preserved in people with Alzheimer's disease

People with Alzheimer's disease may retain their ability to empathize, despite declines in other social abilities, finds a new study led by University College London (UCL) researchers.

23 Apr 2025

Scientists develop lab model to study TDP-43 accumulation in neurodegeneration

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, researchers report 'seeding' this accumulation through fragments of the culprit protein created in the lab.

28 Mar 2025

Advanced imaging technique reveals how nuclear pores regulate molecular movement

Just as cities must carefully manage the flow of cars in and out of downtown, cells regulate the movement of molecules into and out of the nucleus.

22 Mar 2025

Deep sleep may protect against neurodegeneration

Sleep disturbances may accelerate neurodegeneration, but whether they cause or result from disease remains unclear. Improving sleep quality could help protect against cognitive decline and brain aging.

20 Mar 2025

New scientific clue could unlock key cellular pathway leading to neurodegenerative diseases

In Nature Neuroscience, UConn School of Medicine researchers have revealed a new scientific clue that could unlock the key cellular pathway leading to devastating neurodegenerative diseases like Alzheimer's disease, and the progressive damage to the brain's frontal and temporal lobes in frontotemporal degeneration (FTD) and the associated disease amyotrophic lateral sclerosis (ALS).

14 Mar 2025

Frontotemporal Dementia News and Research

UCSF discovery points to new strategies for Alzheimer's treatment

APOE ε4 variant reveals hidden risk factors beyond Alzheimer’s

New AI tool helps clinicians identify brain activity patterns linked to nine types of dementia

Glycogen metabolism in neurons emerges as key to fighting Alzheimer's

New AI tool helps clinicians identify brain activity patterns linked to nine types of dementia

UK study finds small proportion of early Alzheimer’s patients suitable for latest treatments

UC Irvine researchers uncover altered RNA processing in ALS

Epileptic seizures more common in frontotemporal dementia patients than previously known

Stress granules play a protective role against neurodegenerative disease

Herpes virus infection linked to higher Alzheimer’s risk, study shows antiherpetic drugs may help

Study offers new clues to early detection of frontotemporal dementia in middle age

Early detection of primary progressive aphasia through speech and hearing tests

TDP-43 dysfunction in brain blood vessels may drive Alzheimer's and ALS progression

Both low and moderate-high intensity exercise could help fight against Alzheimer's

New approach may prevent neurotoxic protein aggregates in ALS

Emotional empathy may be preserved in people with Alzheimer's disease

Scientists develop lab model to study TDP-43 accumulation in neurodegeneration

Advanced imaging technique reveals how nuclear pores regulate molecular movement

Deep sleep may protect against neurodegeneration

New scientific clue could unlock key cellular pathway leading to neurodegenerative diseases

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News