Glioma News and Research

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Glioma is a cancer of the brain that begins in glial cells (cells that surround and support nerve cells).

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

Patients with the deadliest form of brain cancer, glioblastoma, who received MRI-guided focused ultrasound with standard-of-care chemotherapy had a nearly 40 percent increase in overall survival in a landmark trial of 34 patients led by University of Maryland School of Medicine (UMSOM) researchers.

24 Nov 2025

Black cumin: A promising natural agent with potential against chronic diseases

Black cumin seeds contain diverse secondary metabolites, including thymoquinone, flavonoids, triterpenoids and alkaloids, that demonstrate broad antimicrobial, antioxidant, anti-inflammatory and anticancer activity. Early preclinical and limited clinical evidence shows therapeutic potential across chronic diseases, supported by mechanistic and structure activity relationship findings.

24 Nov 2025

Focused ultrasound can be safely used in children being treated for brain cancer

Columbia University researchers are the first to show that focused ultrasound - a non-invasive technique that uses sound waves to enhance the delivery of drugs into the brain - can be safely used in children being treated for brain cancer.

19 Nov 2025

Unexpected traces of bacteria found within brain tumors

Researchers at The University of Texas MD Anderson Cancer Center have uncovered unexpected traces of bacteria within brain tumors.

14 Nov 2025

LRIG1 could serve as important biomarker to distinguish between glioma types and grades

A new research paper was published in Oncotarget (Volume 16) on November 6, 2025, titled "LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas."

12 Nov 2025

St. Jude study maps treatment strategy for rare infant gliomas

Clinician-scientists at St. Jude Children's Research Hospital and collaborators have conducted the largest study of infant-type hemispheric glioma (IHG) ever reported, uncovering key factors that could be used to guide treatment strategies for this rare pediatric brain tumor.

11 Nov 2025

New molecule offers a promising avenue to treat triple-negative breast cancer

A new molecule developed by researchers at Oregon Health & Science University offers a promising avenue to treat intractable cases of triple-negative breast cancer - a form of cancer that is notoriously aggressive and lacks effective treatments.

7 Nov 2025

Fundamental challenges and cutting-edge strategies in developing new GBM CAR-T therapies

Glioblastoma (GBM), the most aggressive primary brain tumor, continues to portend a poor prognosis with median survival under two years, despite standard care involving surgery, radiation, and temozolomide chemotherapy.

30 Oct 2025

Innovative system accurately detects genetic mutations in the brain tumor within 25 minutes

A research team in Japan has developed an innovative system that can accurately detect genetic mutations in the brain tumor within just 25 minutes.

9 Oct 2025

Missing messenger RNA fragments unlock new immunotherapy targets in pediatric brain tumors

A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues.

18 Aug 2025

Electrophysiology-based strategies enhance cancer immunotherapy

Tumor electrophysiological abnormalities, characterized by membrane potential dysregulation, ion channel network remodeling, and microenvironmental signaling interactions, are critical drivers of malignancy.

17 Aug 2025

Nudibranchs (sea slugs) emerge as a promising source of cancer drugs

Researchers reviewed the antitumor potential of bioactive compounds from nudibranchs, marine mollusks that acquire or synthesize potent chemical defenses. These compounds, often sourced from their diet, show promising cancer-fighting activity through mechanisms like DNA damage, oxidative stress, and apoptosis.

12 Aug 2025

Polyphenols and exercise show promise in fighting gliomas

A new review in Food Science & Nutrition highlights how combining dietary polyphenols with structured exercise can enhance brain function, regulate epigenetics, and support glioma management. The authors outline mechanisms, patient-centered strategies, and research gaps for turning this synergy into clinical practice.

12 Aug 2025

HOXB13 emerges as a context-dependent regulator in cancer biology

HOXB13, a B-class homeobox transcription factor, sits at the hub of developmental gene networks yet has emerged as a double-edged sword in human cancer.

5 Aug 2025

Researchers honored for groundbreaking work in cancer neuroscience

The University of Virginia School of Medicine's Harald Sontheimer, PhD, and Stanford's Michelle Monje, MD, PhD, have received the 2025 International Prize in Translational Neuroscience from the Gertrud Reemtsma Foundation for their pioneering research in the emerging field of cancer neuroscience.

18 Jul 2025

Niigata University team reports novel treatment for IDH2-mutant brainstem glioma

A group led by the Department of Neurosurgery at the Brain Research Institute, Niigata University, has successfully treated a patient with a brainstem glioma harboring a rare IDH2 mutation.

17 Jul 2025

Understanding the human brain architecture through gene coexpression analysis

In a comprehensive Genomic Press Interview published in Brain Medicine, Dr. Michael C. Oldham shares his unconventional journey from advertising executive to computational neuroscientist and his groundbreaking contributions to understanding the human brain's cellular and molecular architecture through gene coexpression analysis.

8 Jul 2025

Aspartame triggers genetic changes tied to glioblastoma severity

Study shows aspartame affects gut microbiome and gene expression in glioblastoma, highlighting potential links to cancer progression and treatment strategies.

8 Jul 2025

Novel tool offers a glimpse into the black box of ALT in aggressive cancers

Each time a cell divides, a small section of each chromosome's protective cap - the telomere - is worn away. Most cells use an enzyme called telomerase to help mitigate this loss, but 10% to 15% of cancers have another mechanism called the alternative lengthening of telomeres (ALT) pathway.

4 Jul 2025

FAM111B identified as a key driver of glioma progression and therapeutic target

Gliomas are among the deadliest brain tumors, with limited treatment options and poor survival rates. Scientists from China identified FAM111B, a DNA-repair-associated protein, as a key driver of glioma progression.

27 Jun 2025