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Salk's three collaborative projects win 2022 Curebound Discovery Grant

The Salk Institute's American Cancer Society Professor Tony Hunter, Professor Reuben Shaw, and Assistant Professor Graham McVicker are among 12 inaugural 2022 Discovery Grant winners.

19 Oct 2022

Structural analysis of monkeypox virus H1 dual phosphatase as a pan-poxvirus target

In a new study, researchers determined the 1.8-Å resolution crystal structure of the H1 dual specific phosphatase (DSP) of monkeypox virus (MPXV) that is crucial for viral replication, making it an attractive antiviral target.

5 Oct 2022

The potential of NMR-based blood profiling as a single-domain assay to simultaneously predict multidisease onset

Researchers explored the potential of a nuclear magnetic resonance spectroscopy-based metabolomic platform to estimate the risks for the onset of several medical conditions.

27 Sep 2022

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) processing.

19 Sep 2022

New dental coating replicates the composition and microstructure of natural enamel

Scientists have perfected hydroxyapatite, a material for mineralizing bones and teeth. By adding a complex of amino acids to hydroxyapatite, they were able to form a dental coating that replicates the composition and microstructure of natural enamel.

16 Sep 2022

Auranofin inhibits SARS-CoV-2 replication

In a new ISCIENCE journal study, scientists identified an FDA-approved NF-κB inhibitor, Auranofin, which can also control inflammation.

6 Sep 2022

SARS-CoV-2 mutational spectra based on reconstructed phylogenetic tree

In a new study, researchers assessed the impact of mutagenesis on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and the effects of mutations in the neutral regions and non-neutral regions of the genome.

25 Aug 2022

The impact of the P681H spike mutation in the SARS-CoV-2 Alpha variant

Researchers demonstrated the relevance of the P681H spike mutation in the SARS-CoV-2 Alpha variant.

17 Aug 2022

Gut bacterial 'super-producer' of histamine can cause pain flare-ups in some IBS patients

Researchers from McMaster University and Queen's University have discovered a gut bacterial 'super-producer' of histamine that can cause pain flare-ups in some patients with irritable bowel syndrome (IBS).

27 Jul 2022

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

In a recent study posted to the bioRxiv* preprint server, researchers at Weill Cornell Medical College assessed the cleavability of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and related coronaviruses by several proteases of the host.

19 Jun 2022

SARS-CoV-2 variant-specific polymerase chain reaction assay for SARS-CoV-2 genomic surveillance

Researchers reported on the misclassification of the SARS-CoV-2 Omicron BA.1 subvariant as Omicron BA.2 subvariant in an automated variant-specific polymerase chain reaction analysis.

17 Jun 2022

Genomic analysis of the 2022 monkeypox outbreak

In a recent study posted to the bioRxiv* pre-print server, researchers analyzed two genomic sequences of the Monkeypox virus from Belgium and Portugal termed ITM001 and PT0001, respectively, to show that the May 2022 Monkeypox outbreak most likely originated from the West African clade of the virus.

14 Jun 2022

Changes in gut microbiome impact depression

Over the last five years, the effects of the gut microbiome on depression have gained scientific attention, resulting in a significant increase in research papers.

8 May 2022

SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold

A new study describes the development of new molecules with inhibitory activity against the SARS-CoV-2 viral main protease (Mpro) enzyme, based on rattlesnake venom.

29 Apr 2022

Evidence of increased intrinsic cleavability of SARS-CoV-2 Omicron spike protein by host cell furin

Researchers conducted an in vitro analysis to assess the host cell furin-mediated cleavability of the spike protein of the SARS-CoV-2 Omicron (B.1.529) variant.

26 Apr 2022

Quercetin and other plant flavonols show anti-SARS-CoV-2 activity

A new study discusses the potential of certain plant compounds to block SARS-CoV-2 replication within host cells.

24 Apr 2022

Single-dose vaccine delivers protection against cervical cancer-causing HPV comparable to 2 or 3-dose regimes

A recent report suggested that a single dose of the human papillomavirus (HPV) vaccination confers equivalent immunity to a two-dose schedule against cervical cancers caused by HPV.

14 Apr 2022

Study identifies a novel class of angiotensin receptor blockers that interfere with SARS-CoV-2 spike – ACE2 interaction

Scientists have discovered a new generation of angiotensin receptor blockers that may be used to treat coronavirus disease 2019.

11 Apr 2022

Framework for genomic surveillance of SARS-CoV-2 Mpro evolution

A recent study posted to the bioRxiv* preprint server investigated the active genetic evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), its emerging mutations, and the existence of antiviral resistance against Mpro inhibitors like paxlovid.

5 Apr 2022

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

A new study identified mechanisms regulating immune cell plasticity to develop new therapeutics.

31 Mar 2022