Liver Transplantation News and Research

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Immune system found to be more mobile and flexible than previously thought

Researchers at Karolinska Institutet in Sweden have discovered that some natural killer cells, NK cells, temporarily reside in our organs and then leave them via the lymphatic system.

14 Oct 2025

Study reports the world's first genetically engineered pig-to-human liver xenotransplantation

An important new study in the Journal of Hepatology, published by Elsevier, reports the world's first auxiliary liver xenotransplant from a genetically engineered pig to a living human recipient.

9 Oct 2025

Japan's registry transforms outcomes for infants with biliary atresia

Biliary atresia (BA) is the leading cause of liver failure in infants, marked by progressive destruction of the bile ducts. Until the late 1950s, the disease was universally fatal, with no effective treatments. The development of the Kasai portoenterostomy brought new hope, but outcomes varied widely, and many patients still required liver transplantation (LTx).

8 Oct 2025

UCLA researchers identify proteins that guard the liver against damage during transplantation

In a mouse model of liver transplantation, UCLA researchers have identified proteins that act as "protective switches" guarding the liver against damage occurring when blood supply is restored during transplantation, a process known as ischemia-reperfusion injury.

23 Sep 2025

Researchers call for consistent biomarker scoring

More than 1500 persons in Norway have had a liver transplantation. But how can doctors know which patients need extra follow-up or additional treatment so that as many as possible can live a long life afterwards?

23 Sep 2025

Single-cell transcriptomics reveals new players in liver regeneration

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes.

2 Sep 2025

Targeting gut signaling protein may protect against alcohol-related liver damage

Alcohol-associated liver disease (ALD) is a major cause of liver transplantation and death worldwide, and its impact is only growing. In 2022, the annual cost of ALD in the United States was $31 billion.

27 Aug 2025

Breakthroughs in diagnosis and therapy for transthyretin amyloidosis

Transthyretin amyloidosis (ATTR) is caused by the misfolding and aggregation of the transthyretin (TTR) protein, leading to multi-organ damage.

21 Aug 2025

Updated multidisciplinary European guidelines redefine MASLD diagnosis and treatment

The 2024 European clinical practice guidelines introduce a pivotal terminology shift, replacing NAFLD (non-alcoholic fatty liver disease) with MASLD (metabolic dysfunction-associated steatotic liver disease) and NASH with MASH (metabolic dysfunction-associated steatohepatitis).

7 Aug 2025

Vitamin D supplementation reduces liver inflammation and fibrosis largely through TXNIP

Chronic liver disease (CLD) is a major global health concern, affecting approximately 1.5 billion people. This life-threatening disease often progresses silently, eventually leading to worsened conditions like liver cirrhosis or liver cancer.

28 Jul 2025

ANXA2 positive hepatocytes drive migration based repair in acute liver failure

Acute liver failure (ALF) represents a life-threatening condition marked by rapid deterioration of liver function, often necessitating urgent liver transplantation.

18 Jul 2025

Personalized gene editing corrects fatal infant metabolic disorder in world-first treatment

Researchers have used a personalised base-editing gene therapy to successfully treat an infant with carbamoyl-phosphate synthetase 1 (CPS1) deficiency, a rare and life-threatening inborn error of metabolism. This pioneering approach chemically corrects the underlying mutation without cutting DNA, showing promise for precision treatment of ultrarare genetic disorders.

20 May 2025

Study reveals how acetaminophen may actually relieve pain

A new study from Indiana University scientists may aid the pharmaceutical industry in better understanding a popular over-the-counter pain reliever: Tylenol.

16 May 2025

Pentoxifylline offers no survival benefit for severe alcohol-associated hepatitis

Severe alcohol-associated hepatitis (sAH) remains a highly lethal condition with limited therapeutic options. Characterized by rapid liver decompensation, sAH is often accompanied by acute kidney injury (AKI), a complication that substantially worsens prognosis.

13 May 2025

Humanized liver organoids double survival rate in rodent models

One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key "zones" that perform specific major tasks.

16 Apr 2025

Gum disease linked to worsening liver health

There is growing recognition in medicine that what happens in one part of the body can ripple through others.

9 Apr 2025

Advances in organ preservation techniques and future prospects

A review article published in Engineering delves into the crucial field of organ preservation, exploring its history, current techniques, and future prospects.

14 Mar 2025

Asah1 gene plays key role in preventing progression of nonalcoholic fatty liver disease

Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic fatty liver diseases (NAFLD) into more severe forms of liver disease by regulating hepatic lipid homeostasis and cellular maintenance processes.

6 Mar 2025

Breakthrough study defines ideal interval for immunotherapy and liver transplants

Hepatocellular carcinoma (HCC) represents about 80 to 90% of cases of primary liver cancer. On a global level, 905,700 new cases and 830,200 deaths were registered in 2020 according to the World Health Organization.