Muscle Wasting News and Research

RSS

Study sheds light on the role of fibro-adipogenic progenitors in muscle regeneration and degeneration

A recent study has shed new light on the role of fibro-adipogenic progenitors (FAPs) in muscle regeneration, fibrosis, and degeneration.

5 Mar 2025

Insilico Medicine announces preclinical drug discovery benchmarks from 2021 to 2024

Insilico Medicine ( "Insilico") , a clinical stage generative artificial intelligence (AI)-driven biotechnology company today announced a set of preclinical drug discovery benchmarks from the 22 developmental candidate nominations achieved by its platform from 2021 to 2024.

11 Feb 2025

Living in disadvantaged areas reduces ALS survival time by over 30%

Living in a disadvantaged community may decrease the length of time a person can survive with amyotrophic lateral sclerosis, or ALS, by over 30%, a Michigan Medicine-led study suggests.

7 Feb 2025

Communication between body muscle and pituitary gland may play unexpected role in female fertility

A newly discovered line of communication between body muscle and the pituitary gland may play an unexpected role in female fertility, according to a new study.

6 Feb 2025

Neurostimulation improves movement in adults with spinal muscle atrophy

A new drug-free, minimally invasive intervention targets the root cause of progressive loss of neural function in spinal muscle atrophy (SMA), an inherited neuromuscular disease.

5 Feb 2025

Most disease-causing mutations that swap amino acids do so by making proteins less stable

Research shows 60% of missense mutations destabilize proteins, linking protein folding to genetic diseases, including cataracts and neurological disorders.

10 Jan 2025

Unraveling the molecular mechanisms of disease-causing mutations

Most mutations which cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a massive study of human protein variants published today in the journal Nature. Unstable proteins are more likely to misfold and degrade, causing them to stop working or accumulate in harmful amounts inside cells.

9 Jan 2025

University of Oklahoma professor honored with prestigious Palade Prize for pancreatic cancer research

Min Li, Ph.D., a George Lynn Cross Professor of Medicine, Surgery and Cell Biology at the University of Oklahoma College of Medicine and Associate Director for Global Oncology at OU Health Stephenson Cancer Center, will receive the 2024 Palade Prize from the International Association of Pancreatology.

26 Nov 2024

Understanding metabolic alterations and immune dysfunction in acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) is a life-threatening condition characterized by acute deterioration of liver function in patients with pre-existing chronic liver disease.

8 Nov 2024

New insights into cardiac defects in Myotonic Dystrophy Type 1

People with Myotonic Dystrophy Type 1 (DM1), the most common adult-onset form of muscular dystrophy, progressively lose muscle mass and strength in their lower legs, hands, neck and face.

29 Oct 2024

UNF professor secures NIH grant to investigate enzyme's role in muscle atrophy

A University of North Florida biology professor has been awarded a prestigious four-year National Institutes of Health (NIH) grant totaling over $720K to study the functional role of an enzyme called dual-specificity phosphatase 4 (Dusp4) in skeletal muscle atrophy.

3 Oct 2024

New discovery could lead to improved treatments for age- and cancer-related muscle degeneration

With the global population aging rapidly, sarcopenia, a condition that affects millions of older adults and severely diminishes their quality of life, is emerging as an urgent public health issue.

26 Sep 2024

Drug breakthrough provides new hope for cancer patients with cachexia

Researchers discovered a drug that safely and effectively helped cancer patients when they suffered from cachexia (ku-KEK-see-uh), a common condition related to cancer that involves weight loss and muscle wasting.

19 Sep 2024

Study sheds light on the dual nature of cellular senescence

Scientists at Sanford Burnham Prebys and the La Jolla Institute for Immunology have revealed a new secret regarding senescence, a cellular state similar to sleep that is more likely to affect aged cells.

22 Aug 2024

New technique reveals abnormalities in motor neurone disease

Pathological abnormalities associated with motor neurone disease have been identified using a new technique developed at the University of Birmingham.

8 Aug 2024

Scientists explore early life factors contributing to SMA

Spinal muscular atrophy (SMA) is a severe neurological disease for which there is presently no cure, although current therapies can alleviate symptoms. In the search for better treatment options, scientists at DZNE and the Dresden University of Technology are now drawing attention to previously unnoticed abnormalities in embryonic development. They base their argument on studies of so-called organoids: Laboratory-grown tissue cultures that can reconstruct disease processes. Their findings are published in the journal Cell Reports Medicine.

27 Jul 2024

Blocking IL-11 protein extends lifespan and health in mice by 25%, study shows

Scientists at the Medical Research Council Laboratory of Medical Science and Imperial College London have discovered that 'switching off' a protein called IL-11 can significantly increase the healthy lifespan of mice by almost 25%.

18 Jul 2024

Breakthrough gene therapy offers hope for Duchenne muscular dystrophy

A new gene therapy treatment for Duchenne muscular dystrophy shows promise of not only arresting the decline of the muscles of those affected by this inherited genetic disease, but perhaps, in the future, repairing those muscles.

18 Jul 2024

Study reveals how inflammation weakens muscles during illness

Infections and neurodegenerative diseases cause inflammation in the brain. But for unknown reasons, patients with brain inflammation often develop muscle problems that seem to be independent of the central nervous system. Now, researchers at Washington University School of Medicine in St. Louis have revealed how brain inflammation releases a specific protein that travels from the brain to the muscles and causes a loss of muscle function.

13 Jul 2024

No organ is an island: Genetic study shows unique but interconnected aging markers

Researchers analyzed genetic underpinnings of biological age gaps in nine organ systems using a large dataset from the U.K. Biobank, revealing organ-specific yet interconnected genetic architectures. Their findings may aid in understanding complex diseases and developing holistic treatments.

2 Jul 2024