Post Exposure Prophylaxis News and Research

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Population-level big data reveals COVID-19 phenotypes

A recent study published in The Lancet Digital Health journal assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection trajectories in England utilizing electronic health records (EHRs).

13 Jun 2022

A polymer-nanoparticle hydrogel to subcutaneously deliver broadly neutralizing antibodies against SARS-CoV-2

Researchers compared the polymer-nanoparticle hydrogel system and standard routes of delivery of broadly neutralizing antibodies against SARS-CoV-2 in a mouse model.

27 May 2022

STIs could be prevented with a dose of doxycycline after unprotected sex

A significant proportion of bacterial sexually transmitted infections (STIs) - gonorrhea, chlamydia or syphilis - were prevented with a dose of doxycycline after unprotected sex, according to preliminary results of a clinical trial that closed early because it was very effective for men who have sex with men and transgender women who are living with HIV or are taking HIV pre-exposure prophylaxis (PrEP).

25 May 2022

Researchers explore COVID-19 vaccination in immunocompromised individuals

A new study discusses the safety and efficacy of the COVID-19 vaccination and potential strategies to optimize protection in patients with impaired immunity.

17 May 2022

Rabies transmission via vampire bats identified in Brazil

In a new study, researchers evaluated the concerns regarding the hematophagous bat-borne rabies in Brazil.

9 Mar 2022

Impact of post-exposure BNT162b2 prophylaxis against SARS-CoV-2 infections

In a new study, researchers determined evidence for post-exposure vaccination in reducing the mortality rate of COVID-19 and concluded that post-exposure prophylaxis successfully decreased SARS-CoV-2-associated death rates.

11 Jan 2022

Study shows probiotics can reduce symptoms of COVID-19 when taken post-exposure

A new study shows how a daily use of Lactobacillus rhamnosus GG (LGG) probiotic may protect against symptom development in instances when it is used as post-exposure prophylaxis within seven days after exposure to severe acute respiratory syndrome coronavirus 2.

7 Jan 2022

CDC raises awareness of the risks of rabies from bats in the U.S.

The Centers for Disease Control and Prevention (CDC) is raising awareness of the risks of rabies from bats in the U.S. after three people, including one child, died from rabies between late September and early November 2021.

6 Jan 2022

Monoclonal antibody treatment of COVID-19 reduces viral shedding

Researchers aim to understand the potential benefits of mAbs in preventing and treating SARS-CoV-2 infection.

5 Jan 2022

Transplant recipients benefit from a COVID-19 vaccine booster

A new preprint research paper posted to the medRxiv* server describes the reduction in humoral immunity in SOTR following vaccination, as well as the improvement with an additional dose of the vaccine.

4 Jan 2022

Anti-SARS-CoV-2 antibody infusion shown to demonstrate robust immune response following COVID-19 vaccination

A new study expands the understanding of the impact of receiving a prophylactic monoclonal antibody infusion, as well as other variables, on the endogenous immune response to complete COVID-19 immunization.

20 Dec 2021

Study suggests convalescent plasma appears safe but does not prevent SARS-CoV-2 infection

A new study assesses the safety and efficacy of SARS-CoV-2 convalescent plasma containing high titers of anti-SARS-CoV-2 antibodies as PEP.

16 Dec 2021

Subcutaneously administered monoclonal antibodies associated with reduced hospitalization and death amongst COVID 19 outpatients

A new preprint describes the results of a study that compares intravenous administration of one such therapy to its subcutaneous use, in terms of clinical outcomes.

3 Dec 2021

Novel peptide-antibody fusion molecule enhances SARS-CoV-2 variant neutralization

A recent study reports neutralizing efficacy for a fused peptide-antibody molecule against SARS-CoV-2, providing hope that therapeutic neutralizing antibodies may soon be available.

3 Dec 2021

REGEN-COV is effective in preventing severe COVID-19 in immunocompromised individuals

A recent study assesses the efficacy of repeat doses of REGEN-COV in SARS-CoV-2-negative adults who were healthy or had chronic medical conditions.

18 Nov 2021

REGEN-COV shown to rapidly reduce SARS-CoV-2 viral load in hospitalized COVID-19 patients

Studies have shown that mortality rates in hospitalized patients with COVID-19 are high, ranging between 10% and 30%. REGEN-COV®, a combination of monoclonal antibodies casirivimab and imdevimab, is approved in the United States and other regions for emergency treatment of COVID-19 outpatients with mild to moderate SARS-CoV-2 infection and post-exposure prophylaxis.

10 Nov 2021

CDC lab testing identifies deadly bacteria in an aromatherapy spray

Laboratory testing at the U.S. Centers for Disease Control and Prevention (CDC) has identified the bacteria Burkholderia pseudomallei in an aromatherapy spray - the same type of bacteria that sickened four people in the United States earlier this year.

22 Oct 2021

Post-exposure prophylaxis with monoclonal antibodies may reduce health system burden in the US

In a study conducted at the University of Washington, USA, the researchers assert that post-exposure prophylaxis with monoclonal antibodies could improve the clinical outcomes and health system costs regarding coronavirus disease (COVID-19). The study is currently available on the medRxiv* preprint server.

6 Sep 2021

New evidence provides strong support for the halt on prescribing hydroxychloroquine for COVID-19

In 2021, in the United States alone, there have been more than 560,000 prescriptions of hydroxychloroquine for the prevention, post-exposure and treatment of COVID-19.

31 Aug 2021

Varenicline blocks SARS-CoV-2 infection in cells and animal models

A new paper released on the bioRxiv* preprint server suggests that the nicotinic acetylcholine receptor (nACHR) agonist, varenicline tartrate, has antiviral activity against the virus.

5 Jul 2021