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AlphaFold3 reveals molecular interactions driving T cell recognition

Researchers at the Translational Genomics Research Institute (TGen), part of City of Hope, have developed a new approach using the artificial intelligence platform AlphaFold3 to predict whether a T cell receptor will recognize a specific antigen based solely on its genetic sequence.

3 Nov 2026

Gq-coupled receptors activate cAMP signaling to regulate brain synapses

By studying G protein–coupled receptors (GPCRs) in mouse hippocampal slices, Qi Ding and colleagues provide evidence of unconventional receptor signaling that has implications for the function of synapses in the brain.

3 Nov 2026

DHA improves autism-like behaviors in a preclinical rat study

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition marked by social and communication difficulties and repetitive behaviors.

3 Nov 2026

Compounds that give citrus fruits their scent may affect gut health

A review published in Food & Function found that dietary terpenoids, naturally occurring compounds in fruits, herbs, and vegetables, can suppress inflammatory signalling and improve intestinal barrier function in laboratory and animal studies. However, human evidence remains limited to two small studies of geraniol-based interventions for irritable bowel syndrome, with further research needed to establish clinical efficacy, appropriate dosing, and long-term safety.

3 Nov 2026

Vanderbilt researchers create massive transcriptomic atlas of breast cancer

A new molecular map of breast cancer has identified novel forms of the disease and provides a foundation for selecting personalized treatments guided by a tumor's molecular characteristics rather than standard pathology alone.

3 Nov 2026

Study identifies new target to improve ulcerative colitis treatments

Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease in which persistent mucosal inflammation damages the epithelial barrier.

3 Nov 2026

Alliance for Clinical Trials in Oncology highlights key role of clinical research in advancing men's cancer care

Every November, millions worldwide grow mustaches and join Movember, a global movement launched in 2003 to spark conversations about men's health, including prostate cancer, testicular cancer, and mental health.

3 Nov 2026

New study identifies biological mechanism driving therapy resistance in advanced prostate cancer

A multi-institutional collaborative study led by researchers at the University of Chicago and the Fred Hutchinson Cancer Center has identified a previously unknown biological mechanism that controls cell identity and treatment resistance in advanced prostate cancer.

3 Nov 2026

New hormone receptor strategy offers targeted treatment for lupus

Researchers at the University of California, Riverside and City of Hope have identified a new strategy for treating systemic lupus erythematosus (SLE), or lupus, an autoimmune disease in which the immune system attacks healthy tissues.

2 Nov 2026

Targeting EGFR signaling to reduce mucus overproduction in lung diseases

Airway mucus is part of innate lung defense, but when production overwhelms clearance, it obstructs airflow and worsens disease.

2 Nov 2026

Could GLP-1 drugs help women with PCOS beyond weight loss?

A scoping review of 28 studies suggests that GLP-1 receptor agonists may improve androgen levels and menstrual function in women with polycystic ovary syndrome (PCOS), alongside their established metabolic benefits. Evidence for improved ovulation, fertility, and pregnancy outcomes remains limited, and the researchers could not determine whether reproductive benefits result directly from the drugs or from weight loss and improved metabolic health.

1 Nov 2026

Mechanical force triggers metabolic changes that promote orthodontic bone formation

Bone adapts to mechanical force through coupled formation and resorption, a principle central to orthodontics.

30 Oct 2026

FDA approves ILUMYA for adults with active psoriatic arthritis

Sun Pharmaceutical Industries Limited announced today that the U.S. Food and Drug Administration (FDA) has approved the supplemental Biologics License Application (sBLA) for ILUMYA® (tildrakizumab-asmn) for the treatment of adults with active psoriatic arthritis (PsA).

30 Oct 2026

Hyperactive cancer-promoting proteins help tumor cells evade immune attack

The immune system may recognize a cancer cell and still fail to destroy it. Researchers at Hiroshima University and their international collaborators found that hyperactive YAP and TAZ (YAP/TAZ), two cancer-promoting proteins, were associated with genomic instability that may make cancer cells more recognizable to the immune system, while also increasing PD-L2, which helps the cells suppress T-cell attack.

30 Oct 2026

Platelet hyperactivity drives glioblastoma progression and deep vein thrombosis

New Cleveland Clinic research published in Cancer Cell shows that people with glioblastoma have more active platelets, which are cells involved in blood clotting. Platelets also communicate with other cells and can influence immune activity. The overactive platelets in people with glioblastoma slow the activity of cancer-fighting T cells, which can contribute to tumor growth and cancer progression.

30 Oct 2026

Study reveals immune rheostat maintaining skin barrier homeostasis

As the steadfast protector of the body's interior, the skin must be able to swiftly respond to stressors from the outside world and then return to a steady state in order to maintain everyday operations. Coordinating that agile response are epidermal stem cells, which produce the overlying protective layers of specialized skin cells sent to the surface while also maintaining a ready pool of new stem cells to draw from.

30 Oct 2026

Can broccoli sprouts help with insulin resistance? New review offers clues

A review published in the British Journal of Nutrition examines how carotenoids and bioactive compounds in Brassicaceae microgreens may influence obesity, insulin resistance, and type 2 diabetes through metabolic and inflammatory pathways. Small human trials involving broccoli sprouts have reported improvements in selected metabolic markers, but larger, longer-term studies are needed to establish their clinical benefits.

29 Oct 2026

Researchers find simple way to boost engineered T-cell therapies

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a promising new strategy to make cancer-fighting immune cells stronger and potentially longer-lasting, a discovery that could help improve the effectiveness of immunotherapies that use a patient's own immune cells to attack cancer.

29 Oct 2026

Thyroid cancer risks and medication timing with oral GLP-1s

Like most prescriptions, glucagon-like peptide 1 (GLP-1) medications to manage weight come with potential risks.

28 Oct 2026

Ketones may change sleep patterns, but not always for the better

Researchers reviewed animal and human studies and found that ketone bodies may affect sleep stages through energy metabolism and cellular signaling, with the clearest direct evidence involving acetoacetate in mice. They reported mixed human findings and called for controlled studies to separate ketone-specific effects from changes linked to diet, disease, circadian timing, and physiological stress.

28 Oct 2026